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PDCD4抗體 

抗原
Programmed Cell Death 4 (Neoplastic Transformation Inhibitor) (PDCD4)
別名 h731, MGC69337, PDCD4, D19Ucla1, Ma3, Tis, Dug, H731
抗原表位
其他選擇 C-Term
pSer457(27),C-Term (23),AA 1-469 (16),N-Term (15),pSer67 (11),AA 120-149 (7),Internal Region (4),Ser457 (3),AA 100-150 (2),AA 121-149 (2),AA 210-221 (2),AA 419-469 (2),AA 1-50 (1),AA 176-469 (1),AA 212-357 (1),AA 236-469 (1),AA 33-82 (1),AA 351-368 (1),AA 420-469 (1),AA 447-465 (1),AA 458-468 (1),Center (1),Lys453 (1),Tyr674 (1),Tyr69 (1),phosphorylated (1)
適用
其他選擇 Human, Murine, Rat ((Rattus))
Human(152),Rat ((Rattus)) (85),Murine (84),Xenopus laevis (11),Bovine (4),Dog (Canine) (4),Frog (4),Pig (Porcine) (2),Monkey (1),Staphylococcus aureus (S. aureus) (1)
宿主
其他選擇 Rabbit
Rabbit(122),Mouse (28),Goat (4),Sheep (1)
克隆類(lèi)型
多克隆
標(biāo)記
其他選擇 非結(jié)合性
Biotin(4),FITC (2),HRP (2),APC (1),Alexa Fluor 350 (1),Alexa Fluor 488 (1),Alexa Fluor 555 (1),Alexa Fluor 647 (1),Alkaline Phosphatase (AP) (1),Cy3 (1),Cy5 (1),Cy5.5 (1),Cy7 (1),PE (1)
應(yīng)用范圍
其他選擇 Enzyme Immunoassay (EIA), Immunohistochemistry (Frozen Paraffin-embedded Sections) (IHC (frpe)), Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Western Blotting (WB)(135),ELISA (81),Immunohistochemistry (IHC) (59),Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (33),Immunofluorescence (IF) (17),Immunofluorescence (Paraffin-embedded Sections) (IF (p)) (10),Immunohistochemistry (Frozen Paraffin-embedded Sections) (IHC (frpe)) (10),Enzyme Immunoassay (EIA) (9),Immunoprecipitation (IP) (9),Immunocytochemistry (ICC) (7),Immunoassay (IA) (3),Immunohistochemistry (Frozen Sections) (IHC (fro)) (3),Flow Cytometry (FACS) (2)
[Pubmed] 4 references available
規(guī)格 0.1 mg
發(fā)貨至 中國(guó) (更改)
發(fā)貨時(shí)間 29至35個(gè)工作日

PDCD4抗體 

產(chǎn)品細(xì)節(jié)

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產(chǎn)品細(xì)節(jié)

顯示 隱藏
免疫原 PDCD4 antibody was raised against a 19 amino acid peptide from near the carboxy terminus of human PDCD4.
亞型 IgG
特異性 This antibody detects PDCD4 at C-term.
交叉反應(yīng) （詳細(xì)） Species reactivity (tested):Human, mouse, rat
純化方法 Peptide affiinity chromatography

 目標(biāo)詳細(xì)情況

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目標(biāo)詳細(xì)情況

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別名 PDCD4
背景 Apoptosis, also known as programmed cell death, plays major roles in development and normal tissue turnover in addition to tumor formation. During this process, the expression patterns of numerous genes are radically altered. One such gene is the programmed cell death protein 4 (PDCD4), whose expression was found to be upregulated in all cell lines following the onset of apoptosis. PDCD4 encodes a tumor suppressor protein whose expression is lost in carcinomas of breast, colon, lung and prostate. It can bind to and inhibit the helicase activity of the eukaryotic translation initiation factor 4A (4) and inhibit the transactivation and transformation mediated by the transcription factor AP-1. The kinase Akt regulates PDCD4 by phosphorylation, decreasing the ability of PDCD4 to interfere with the transactivation of AP-1-responsive promoter by c-Jun. There are two known isoforms of PDCD4.Synonyms: H731, Neoplastic transformation inhibitor protein, Nuclear antigen H731-like, Programmed cell death protein 4
基因ID 27250
NCBI Accession NP_663314
UniProt Q53EL6
研究領(lǐng)域 Cancer, Apoptosis/Necrosis, Transcription Factors, Signaling

 使用細(xì)節(jié)

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使用細(xì)節(jié)

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應(yīng)用備注 ELISA. Western blot: 0.5 - 1?μg/mL. Immunohistochemistry on paraffin sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
限制 For Research Use only

貯存及處理

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貯存及處理

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緩沖液 PBS containing 0.02?% sodium azide
儲(chǔ)存液 Sodium azide
注意事項(xiàng) This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
注意事項(xiàng) Avoid repeated freezing and thawing.
儲(chǔ)存條件 4 °C/-20 °C

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