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PSEN1 抗體

抗原
Presenilin 1 (PSEN1)
別名 pre1, psen, zfPS1, zf-PS1, ad3, fad, ps1, s182, X-PS-beta, X-PS-alpha, AD3, FAD, PS-1, PS1, S182, Ad3h
抗原表位
其他選擇 C-Term
N-Term(35),C-Term (21),pSer357 (7),AA 14-33 (5),AA 431-467 (3),AA 1-80 (2),AA 25-50 (2),AA 313-334 (2),Middle Region (2),pSer310 (2),AA 1-50 (1),AA 1-79 (1),AA 10-30 (1),AA 21-34 (1),AA 21-80 (1),AA 225-359 (1),AA 248-431 (1),AA 257-352 (1),AA 263-378 (1),AA 275-367 (1),AA 280-379 (1),AA 298-407 (1),AA 311-322 (1),AA 323-372 (1),AA 345-359 (1),AA 9-26 (1),Internal Region (1),Ser28 (1),Ser375 (1),Ser45 (1),Thr41 (1),Val293 (1)
適用
其他選擇 Human, Murine, Rat ((Rattus))
Human(178),Rat ((Rattus)) (80),Murine (56),Bovine (36),Dog (Canine) (36),Pig (Porcine) (36),Chicken (24),Rabbit (24),Monkey (5),Hamster (1)
宿主
其他選擇 Rabbit
Rabbit(132),Mouse (39),Goat (9),Chicken (2),Rat (2),Sheep (2)
克隆類型
多克隆
標(biāo)記
其他選擇 非結(jié)合性
Biotin(6),FITC (6),HRP (4),Alexa Fluor 350 (3),Alexa Fluor 488 (3),Alexa Fluor 555 (3),Alexa Fluor 647 (3),Cy3 (3),Cy5 (3),Cy5.5 (3),Cy7 (3),APC (1),Alkaline Phosphatase (AP) (1),CF (1),PE (1)
應(yīng)用范圍
其他選擇 Enzyme Immunoassay (EIA), Immunohistochemistry (Frozen Paraffin-embedded Sections) (IHC (frpe)), Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Western Blotting (WB)(133),ELISA (72),Immunohistochemistry (IHC) (61),Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (39),Immunofluorescence (Paraffin-embedded Sections) (IF (p)) (30),Immunoprecipitation (IP) (14),Immunohistochemistry (Frozen Sections) (IHC (fro)) (13),Immunohistochemistry (Frozen Paraffin-embedded Sections) (IHC (frpe)) (10),Enzyme Immunoassay (EIA) (7),Immunofluorescence (IF) (7),Immunocytochemistry (ICC) (6),Flow Cytometry (FACS) (3),Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (1)
[Pubmed] 4 references available
規(guī)格 0.1 mg
發(fā)貨至 中國(guó) (更改)
發(fā)貨時(shí)間 29至35個(gè)工作日

PSEN1 抗體

產(chǎn)品細(xì)節(jié)

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產(chǎn)品細(xì)節(jié)

顯示 隱藏
免疫原 Presenilin1 antibody was raised against a 23 amino acid peptide from near the carboxy terminus of human presenilin1.
亞型 IgG
特異性 This antibody detects Presenilin-1. It has no cross-reactivity to presenilin-2.
交叉反應(yīng) （詳細(xì)） Species reactivity (tested):Human, mouse, rat
純化方法 Peptide affinity chromatography

目標(biāo)詳細(xì)情況

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目標(biāo)詳細(xì)情況

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別名 Presenilin-1
背景 Presenilin1 was initially identified a marker of susceptibility to early-onset Alzheimer's disease. In addition to PEN2, nicastrin and APH-1, Presenilin1 forms the g-secretase protein complex, a membrane-bound aspartyl protease that can cleave certain proteins at peptide bonds buried within the hydrophobic environment of the lipid bilayer. This cleavage is responsible for a key step in signaling from several cell-surface receptors and is thought to be required for the generation of the neurotoxic amyloid peptides that are central to the pathogenesis of Alzheimer's disease. Like the tumor necrosis factor-a-converting enzyme (TACE) and the b-site cleavage enzyme (BACE) protease families, g-secretase will cleave the amyloid precursor protein (APP), but within the intramembrane region of APP, resulting in either the non-toxic p3 (from the a and g cleavage site) or the toxic Ab amyloid peptide (from the b and g cleavage site). It is thought that accumulation of the Ab peptide is the precursor to Alzheimer's disease. Multiple isoforms of presenilin1 are known to exist.Synonyms: AD3, AF3, Alzheimer Disease 3, FAD, PS-1, PS1, PSEN1, PSNL1, Presenilin 1, S182
基因ID 5663
NCBI Accession NP_000012
UniProt P49768
研究領(lǐng)域 Alzheimer's Disease

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使用細(xì)節(jié)

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應(yīng)用備注 ELISA. Western blot: 0.5 - 1?μg/mL. Immunohistochemistry on paraffin sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
限制 For Research Use only

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緩沖液 PBS containing 0.02?% sodium azide
儲(chǔ)存液 Sodium azide
注意事項(xiàng) This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
注意事項(xiàng) Avoid repeated freezing and thawing.
儲(chǔ)存條件 4 °C/-20 °C

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