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SKIP抗體

抗原
SKIP
別名 SKIP, 4930544G21Rik, A930009L15Rik, AI852220, mKIAA1678, RGD1311951, Skip
抗原表位
其他選擇 C-Term
C-Term(6),AA 1-110 (1),AA 1359-1651 (1),AA 182-448 (1),AA 239-516 (1)
適用
其他選擇 Human, Murine, Rat ((Rattus))
Human(14),Murine (8),Rat ((Rattus)) (8)
宿主
其他選擇 Rabbit
Rabbit(13),Mouse (1)
克隆類型
多克隆
應用范圍
其他選擇 Enzyme Immunoassay (EIA), Immunofluorescence (IF), Western Blotting (WB)
Western Blotting (WB)(14),Immunofluorescence (IF) (9),ELISA (8),Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (3),Immunocytochemistry (ICC) (2),Fluorescence Microscopy (FM) (1),Immunohistochemistry (Frozen Paraffin-embedded Sections) (IHC (frpe)) (1),Immunohistochemistry (IHC) (1)
[Pubmed] 4 references available
規(guī)格 0.1 mg
發(fā)貨至 中國 (更改)
發(fā)貨時間 29至35個工作日

SKIP抗體

產品細節(jié)

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產品細節(jié)

顯示 隱藏
免疫原 SkiP antibody was raised against a 16 amino acid peptide from near the carboxy terminus of human SkiP.
亞型 IgG
特異性 This antibody detects SKIP.
交叉反應 （詳細） Species reactivity (tested):Human, mouse, rat
純化方法 Peptide affinity chromatography

目標詳細情況

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目標詳細情況

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背景 TGF-beta and the bone morphogenic proteins (BMPs) are key signaling proteins that regulate numerous cellular processes such as embryonic development and tumorigenesis (1). Both signal through the Smad protein family and are negatively regulated by Ski and SnoN, two related proto-oncoproteins (2,3). Ski functions by binding to the Smad proteins activated by TGF-beta and the (BMPs) and preventing their phosphorylation, inhibiting their ability to bind DNA and activate the transcription of downstream genes (4,5). SkiP was originally identified as a Ski-interacting protein (6) and was later found to augment the signals induced by TGF-beta but inhibit transcription induced by BMP-2 (7) in C2C12 cells, suggesting that SkiP is a key player in the signaling cascades inititated by TGF-beta and the BMP protein family.Synonyms: NCoA-62, Nuclear protein SkiP, Nuclear receptor coactivator NCoA-62, SKIIP, SNW domain-containing protein 1, SNW1, Ski-interacting protein
基因ID 22938
NCBI Accession NP_036377
UniProt Q13573
研究領域 Signaling, Cytoskeleton, Microfilaments

使用細節(jié)

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使用細節(jié)

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應用備注 ELISA. Western blot: 0.5 - 1?μg/mL. Immunoflourescence.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
限制 For Research Use only

貯存及處理

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貯存及處理

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緩沖液 PBS containing 0.02?% sodium azide
儲存液 Sodium azide
注意事項 This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
注意事項 Avoid repeated freezing and thawing.
儲存條件 4 °C/-20 °C

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