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基質(zhì)細胞衍生因子1抗體

英文名稱 SDF1
中文名稱 基質(zhì)細胞衍生因子1抗體
別    名 CXCL12; SDF1 alpha; C-X-C motif chemokine 12; Chemokine (C X C motif) ligand 12; CXCL12; hIRH; hSDF-1; Intercrine reduced in hepatomas; IRH; PBSF; PBSF; Pre B cell growth stimulating factor; Pre-B cell growth-stimulating factor; SCYB12; SDF 1 alpha; SDF-1; SDF 1 beta; SDF 1b; SDF-1; SDF-1-alpha(3-67); SDF1; SDF1_HUMAN; SDF1a; SDF1b; Stromal cell derived factor 1; TLSF a; TLSF b; TLSFa; TLSFb; TPAR1.
 
說 明 書 0.1ml  0.2ml  
研究領(lǐng)域 細胞生物  免疫學(xué)  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, Chicken, Dog, Pig, Guinea Pig, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 8kDa
細胞定位 分泌型蛋白 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human SDF-1/CXCL12
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
This gene encodes a stromal cell-derived alpha chemokine member of the intercrine family. The encoded protein functions as the ligand for the G-protein coupled receptor, chemokine (C-X-C motif) receptor 4, and plays a role in many diverse cellular functions, including embryogenesis, immune surveillance, inflammation response, tissue homeostasis, and tumor growth and metastasis. Mutations in this gene are associated with resistance to human immunodeficiency virus type 1 infections. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2013].

Function:
Chemoattractant active on T-lymphocytes, monocytes, but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. Also binds to another C-X-C chemokine receptor CXCR7, which activates the beta-arrestin pathway and acts as a scavenger receptor for SDF-1. SDF-1-beta(3-72) and SDF-1-alpha(3-67) show a reduced chemotactic activity. Binding to cell surface proteoglycans seems to inhibit formation of SDF-1-alpha(3-67) and thus to preserve activity on local sites. Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. Stimulates migration of monocytes and T-lymphocytes through its receptors, CXCR4 and CXCR7, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins. SDF1A/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through LYN kinase. Inhibits CXCR4-mediated infection by T-cell line-adapted HIV-1. Plays a protective role after myocardial infarction. Induces down-regulation and internalization of CXCR7 expressed in various cells. Has several critical functions during embryonic development; required for B-cell lymphopoiesis, myelopoiesis in bone marrow and heart ventricular septum formation.xy-11135R    PCDHB16原鈣粘蛋白16抗體
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xy-6064R    PRSS8絲氨酸蛋白酶8抗體
xy-1652R    phospho-PAK1/2/3(Thr423)磷酸化p21激活激酶1/2/3抗體
xy-6051R    Prostaglandin dehydrogenase 1前列腺素脫氫酶1抗體
xy-2505R    phospho-PRKCZ(Thr500)磷酸化蛋白激酶C(T500)抗體
xy-1650R    phospho-P53(Ser392)磷酸化腫瘤抑制基因P53抗體
xy-1653R    phospho-PAK1 (Ser144)磷酸化p21激活激酶1抗體
xy-1654R    phospho-PAK2 (Ser141)磷酸化p21激活激酶2抗體
xy-1655R    phospho-PAK3 (Ser139)磷酸化p21激活激酶3抗體
xy-1651R    phospho-PAK1+PAK2+PAK3 (Ser141)磷酸化p21激活激酶1/2/3抗體
xy-1656R    phospho-P70 S6 Kinase beta (Thr228)磷酸化核糖體S6蛋白激酶抗體
xy-2638R    PROK1/PRK1/EG-VEGF內(nèi)分泌腺衍生血管內(nèi)皮生長因子抗體
xy-2469R    PERK蛋白激酶樣內(nèi)質(zhì)網(wǎng)激酶抗體
xy-2899R    PMSA前列腺特異膜抗原抗體
xy-0128R    PI3 kinase p85 alpha subunit磷脂酰肌醇激酶抗體
xy-0234R    PLGF胎盤生長因子抗體
xy-0520R    PKA alpha + beta蛋白激酶A抗體
xy-0267R    PKC beta 1 + 2蛋白激酶C beta 1/2抗體
xy-0281R    PLGF胎盤生長因子抗體
xy-0280R    PLGF胎盤生長因子抗體
xy-0235R    PMP22外周髓鞘蛋白-22抗體
xy-1048R    Podoplanin平足蛋白抗體(淋巴管內(nèi)皮細胞蛋白)
xy-0133M    PP-1B蛋白磷酸酯酶-1B抗體
xy-0029R    PP2A alpha + beta蛋白質(zhì)磷酸酶-2A抗體
xy-0490R    PPP4C磷酸酯酶-2Ac抗體
xy-0636R    Phospho-P38 MAPK (Thr180 + Tyr182)磷酸化-絲裂原活化蛋白激酶p38抗體（P-p38 MAPK）
xy-0250R    PPAR delta + betaD型-過氧化酶活化增生受體抗體
xy-0530R    PPAR gamma過氧化酶活化增生受體γ抗體（PPARγ）
xy-0111R    progesterone receptor孕激素受體抗體
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xy-0025M    presenilin 1早老素蛋白-1抗體
xy-0024M    presenilin 1早老素蛋白-1抗體
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