染色體結(jié)構(gòu)維持蛋白6抗體 返回列表頁(yè)

染色體結(jié)構(gòu)維持蛋白6抗體

英文名稱 SMC6
中文名稱 染色體結(jié)構(gòu)維持蛋白6抗體
別    名 SMC6L1; SMC 6; SMC6; SMC6 protein; SMC6 structural maintenance of chromosomes 6 like 1; Structural maintenance of chromosomes 6; Structural maintenance of chromosomes 6 like 1; Structural maintenance of chromosomes protein 6.
   
說 明 書 0.1ml  0.2ml  
研究領(lǐng)域 細(xì)胞生物  細(xì)胞周期蛋白  細(xì)胞分化  表觀遺傳學(xué)  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 126 kDa
細(xì)胞定位 細(xì)胞核 細(xì)胞漿 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human SMC6
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
SMC5/6 complex is recruited to nuclease induced double strand breaks (DSBs) and is required for the recruitment of cohesin to DSBs. The human SMC5/6 complex and the SUMO ligase activity of hMMS21 are required for the prevention of DNA damage induced apoptosis by facilitating DNA repair in human cells.

Function:
Core component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for omere maintenance via recombination in ALT (alternative lengthening of omeres) cell lines and mediates sumoylation of shelterin complex (osome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Required for recruitment of omeres to PML nuclear bodies. 

Subunit:
Forms a heterodimer with SMC5. Component of the SMC5-SMC6 complex which consists at least of SMC5, SMC6, NSMCE2, NSMCE1, NSMCE4A or EID3 and NDNL2.

Subcellular Location:
Cytoplasm. Nucleus.xy-11352R    MAGI1膜相關(guān)鳥苷酸反轉(zhuǎn)激酶1抗體
xy-11353R    Munc13 神經(jīng)突觸前膜胞內(nèi)蛋白13抗體
xy-11322R    Membralin高度保守基因相關(guān)蛋白Membralin抗體
xy-11320R    MNX1運(yùn)動(dòng)神經(jīng)元及胰腺同源蛋白1抗體
xy-11184R    MOBP少突膠質(zhì)細(xì)胞髓鞘相關(guān)蛋白抗體
xy-11189R    MRCK alphaCDC42結(jié)合蛋白激酶α抗體（MRCKα）
xy-1047R    MyD88髓樣分化蛋白抗體
xy-0337R    Myelin Protein Zero外周髓磷脂P0蛋白/P0蛋白抗體
xy-0027R    Melatonin Receptor 1A褪黑素受體1A/松果體素受體1A抗體
xy-3550R    Myogenin肌細(xì)胞生成素抗體
xy-3296R    Phospho-Myt1(Ser83)磷酸化髓鞘轉(zhuǎn)錄因子1抗體
xy-3503R    Mre11DNA損傷關(guān)鍵蛋白Mre11抗體
xy-3293R    Phospho-Mre11 (Ser676)磷酸化DNA損傷關(guān)鍵蛋白Mre11抗體
xy-3504R    MST1蛋白激酶MST抗體
xy-3294R    Phospho-Mst1(Thr183) + Mst2(Thr180)磷酸化蛋白激酶MST抗體
xy-3295R    Phospho-MYL(Ser19)磷酸化肌球蛋白輕鏈2抗體
xy-3505R    Myt1髓鞘轉(zhuǎn)錄因子1抗體
xy-1352R    MCL1髓樣細(xì)胞白血病-1抗體
xy-1369R    MAP2微管相關(guān)蛋白2抗體
xy-9470R    MEF2B肌細(xì)胞增強(qiáng)因子2B抗體
xy-9471R    MESP1心血管發(fā)育中胚層相關(guān)蛋白1抗體
xy-9440R    MTA2轉(zhuǎn)移相關(guān)蛋白2抗體
xy-9375R    MYCBP2MYC結(jié)合蛋白2抗體
xy-9314R    MAP7D1精氨酸/脯氨酸富含卷曲蛋白1抗體
xy-9313R    MAP-9微管相關(guān)蛋白9抗體
xy-9315R    MKLP1有絲分裂驅(qū)動(dòng)蛋白樣1抗體
xy-1061R    Myeloperoxidase/c-ANCA 髓過氧化物酶抗中性粒細(xì)胞胞質(zhì)IgG抗體
xy-0774R    Mouse IgA兔抗小鼠IgA抗體
xy-2909R    MARCKS丙氨酸蛋白激酶C底物Marcks抗體
xy-3522R    MATH1腸道分化干細(xì)胞MATH-1蛋白抗體
xy-3277R    Phospho-MKK7 (Ser271 + Thr275)磷酸化絲裂原活化蛋白激酶MKK7抗體
xy-3276R    Phospho-MEK6 (Ser202)磷酸化絲裂原活化蛋白激酶MKK6抗體
xy-3391R    Phospho-MEK4 (Ser80)磷酸化絲裂原活化蛋白激酶激酶4抗體