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沉默調(diào)節(jié)相關(guān)蛋白4抗體

英文名稱 SIRT4
中文名稱 沉默調(diào)節(jié)相關(guān)蛋白4抗體
別    名 NAD dependent deacetylase sirtuin 4; NAD-dependent ADP-ribosyltransferase sirtuin-4; Silent mating type information regulation 2 homolog; Sir 2 like 4; SIR 2 like protein 4; Sir2 like 4; SIR2 like protein 4; SIR2-like protein 4; SIR2L 4; SIR2L4; SIRT 4; Sirt4; SIRT4_HUMAN; Sirtuin (silent mating type information regulation 2 homolog) 4; Sirtuin (silent mating type information regulation 2 homolog) 4 (S. cerevisiae); Sirtuin 4; Sirtuin type 4; Sirtuin4.
沉默調(diào)節(jié)相關(guān)蛋白4抗體 
說 明 書 0.1ml  0.2ml  
研究領(lǐng)域 心血管  細(xì)胞生物  信號轉(zhuǎn)導(dǎo)  糖尿病  表觀遺傳學(xué)  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, Sheep, Fruit Fly, Zebrafish
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 32kDa
細(xì)胞定位 細(xì)胞漿 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human SIRT4/SIR 2 like protein 4
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
沉默調(diào)節(jié)相關(guān)蛋白4抗體
PubMed PubMed
產(chǎn)品介紹 background:
NAD-dependent protein ADP-ribosyl transferase. Catalyzes the transfer of ADP-ribosyl groups onto target proteins, including mitochondrial GLUD1. Inhibits GLUD1 enzyme activity. Down-regulates insulin secretion. Has no detectable protein deacetylase activity.

Function:
NAD-dependent protein ADP-ribosyl transferase. Catalyzes the transfer of ADP-ribosyl groups onto target proteins, including mitochondrial GLUD1. Inhibits GLUD1 enzyme activity. Down-regulates insulin secretion. Has no detectable protein deacetylase activity. 

Subunit:
Interacts with GLUD1, IDE and SLC25A5. 

Subcellular Location:
Mitochondrion matrix.

Tissue Specificity:
Detected in vascular smooth muscle and striated muscle. Detected in insulin-producing beta-cells in pancreas islets of Langerhans (at protein level). Widely expressed. Weakly expressed in leukocytes and fetal thymus. 

Similarity:
Belongs to the sirtuin family. Class II subfamily. 
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