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組蛋白連接作用蛋白抗體

英文名稱 SHPRH
中文名稱 組蛋白連接作用蛋白抗體
別    名 E3 ubiquitin-protein ligase SHPRH; histone-linker; PHD and RING finger domain-containing helicase; SNF2; SNF2 histone linker PHD RING helicase; SHPRH_HUMAN.

說(shuō) 明 書(shū) 0.1ml  0.2ml  
研究領(lǐng)域 腫瘤  細(xì)胞生物  細(xì)胞周期蛋白  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 193kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human SHPRH
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
SHPRH is a ubiquitously expressed protein that contains motifs characteristics of several DNA repair proteins, transcription factors, and helicases. SHPRH is a functional homolog of S. cerevisiae RAD5

Function:
E3 ubiquitin-protein ligase involved in DNA repair. Upon genotoxic stress, accepts ubiquitin from the UBE2N-UBE2V2 E2 complex and transfers it to 'Lys-164' of PCNA which had been monoubiquitinated by UBE2A/B-RAD18, promoting the formation of non-canonical poly-ubiquitin chains linked through 'Lys-63'. 

Subunit:
Homodimer. Interacts with HLTF, PCNA, UBE2N and RAD18. xy-5433R    PPAP2C磷酸脂磷酸水解酶2抗體
xy-4184R    p107視網(wǎng)膜母細(xì)胞瘤樣蛋白p107抗體
xy-5597R    phospho-P53(Ser376)磷酸化腫瘤抑制基因P53抗體
xy-6061R    PIGR多聚免疫球蛋白受體抗體
xy-11135R    PCDHB16原鈣粘蛋白16抗體
xy-6062R    PRDM2鋅指蛋白R(shí)IZ1抗體
xy-6063R    PRMT6組蛋白精氨酸甲基轉(zhuǎn)移酶6抗體
xy-6064R    PRSS8絲氨酸蛋白酶8抗體
xy-1652R    phospho-PAK1/2/3(Thr423)磷酸化p21激活激酶1/2/3抗體
xy-6051R    Prostaglandin dehydrogenase 1前列腺素脫氫酶1抗體
xy-2505R    phospho-PRKCZ(Thr500)磷酸化蛋白激酶C(T500)抗體
xy-1650R    phospho-P53(Ser392)磷酸化腫瘤抑制基因P53抗體
xy-1653R    phospho-PAK1 (Ser144)磷酸化p21激活激酶1抗體
xy-1654R    phospho-PAK2 (Ser141)磷酸化p21激活激酶2抗體
xy-1655R    phospho-PAK3 (Ser139)磷酸化p21激活激酶3抗體
xy-1651R    phospho-PAK1+PAK2+PAK3 (Ser141)磷酸化p21激活激酶1/2/3抗體
xy-1656R    phospho-P70 S6 Kinase beta (Thr228)磷酸化核糖體S6蛋白激酶抗體
xy-2638R    PROK1/PRK1/EG-VEGF內(nèi)分泌腺衍生血管內(nèi)皮生長(zhǎng)因子抗體
xy-2469R    PERK蛋白激酶樣內(nèi)質(zhì)網(wǎng)激酶抗體
xy-2899R    PMSA前列腺特異膜抗原抗體
xy-0128R    PI3 kinase p85 alpha subunit磷脂酰肌醇激酶抗體
xy-0234R    PLGF胎盤(pán)生長(zhǎng)因子抗體
xy-0520R    PKA alpha + beta蛋白激酶A抗體
xy-0267R    PKC beta 1 + 2蛋白激酶C beta 1/2抗體
xy-0281R    PLGF胎盤(pán)生長(zhǎng)因子抗體
xy-0280R    PLGF胎盤(pán)生長(zhǎng)因子抗體
xy-0235R    PMP22外周髓鞘蛋白-22抗體
xy-1048R    Podoplanin平足蛋白抗體(淋巴管內(nèi)皮細(xì)胞蛋白)
xy-0133M    PP-1B蛋白磷酸酯酶-1B抗體
xy-0029R    PP2A alpha + beta蛋白質(zhì)磷酸酶-2A抗體
xy-0490R    PPP4C磷酸酯酶-2Ac抗體
xy-0636R    Phospho-P38 MAPK (Thr180 + Tyr182)磷酸化-絲裂原活化蛋白激酶p38抗體（P-p38 MAPK）