鈉離子通道β1抗體 返回列表頁(yè)

鈉離子通道β1抗體

英文名稱(chēng) SCN1B
中文名稱(chēng) 鈉離子通道β1抗體
別    名 GEFSP1; SCN1B; SCN1B_HUMAN; sodium channel beta 1 subunit; Sodium channel subunit beta   
說(shuō) 明 書(shū) 0.1ml  0.2ml  
研究領(lǐng)域 神經(jīng)生物學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  通道蛋白  細(xì)胞膜受體  
抗體來(lái)源 Rabbit
克隆類(lèi)型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 22kDa
細(xì)胞定位 細(xì)胞膜 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human SCN1B
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
Crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. The subunit beta-1 can modulate multiple alpha subunit isoforms from brain, skeletal muscle, and heart. Its association with neurofascin may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons.
Tissue specificity; Abundantly expressed in skeletal muscle, heart and brain.

Function:
Crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. The subunit beta-1 can modulate multiple alpha subunit isoforms from brain, skeletal muscle, and heart. Its association with neurofascin may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons.

Subunit:
The voltage-sensitive sodium channel consists of an ion conducting pore forming alpha-subunit regulated by one or more beta-1, beta-2 and beta-3. Beta-1 and beta-3 are non-covalently associated with alpha, while beta-2 is covalently linked by disulfide bonds. Beta-1 or beta-3 subunits associate with neurofascin. Associates with SCN10A (By similarity).

Subcellular Location:
Membrane; Single-pass type I membrane protein.xy-1886R    RPLP0酸性核糖體磷蛋白大亞基P0抗體
xy-9334R    RanBP3RAN結(jié)合蛋白3抗體
xy-9237R    RNF35環(huán)指蛋白35抗體
xy-9223R    RNF70環(huán)指蛋白70抗體
xy-7638R    RHCGRH血型C糖蛋白抗體
xy-3387R    Phospho-Rictor (Thr1135)磷酸化雷帕霉素靶蛋白復(fù)合體2抗體
xy-9254R    RNF138環(huán)指蛋白138抗體
xy-12152R    RTN4RL1Nogo66受體相關(guān)蛋白3抗體
xy-6078R    RASSF3Ras相關(guān)區(qū)域家族1A抗體
xy-5956R    RHCERh血型C抗原抗體
xy-5955R    RASSF6RAS家族關(guān)聯(lián)結(jié)構(gòu)域蛋白6抗體
xy-5953R    RALARas樣蛋白A抗體
xy-2665R    Regucalcin/SMP30衰老標(biāo)記蛋白30抗體
xy-5949R    RNF56環(huán)指蛋白56
xy-1567R    RAMP1受體活性修飾蛋白1抗體
xy-13705R    ROBLD3胞內(nèi)接頭蛋白P14抗體
xy-8480R    RBMX2RNA結(jié)合蛋白X-連鎖蛋白2抗體
xy-4984R    Rb2 p130視網(wǎng)膜母細(xì)胞瘤相關(guān)蛋白p130抗體
xy-3421R    Phospho-A Raf (Tyr301 + Tyr302)磷酸化A-Raf抗體
xy-9175R    RNF10環(huán)指蛋白10抗體
xy-9323R    RanBP2RAN結(jié)合蛋白2/核孔蛋白抗體
xy-9176R    RNF11環(huán)指蛋白11抗體
xy-7008R    RPLP2酸性核糖體磷蛋白P2抗體
xy-6809R    RCAS1腫瘤相關(guān)表面抗原RCAS1抗體
xy-6305R    Ryanodine Receptor心肌蘭尼堿受體抗體（腦肌蘭尼堿受體）
xy-11168R    RASSF5RASSF5抗體
xy-9157R    RNF93環(huán)指蛋白93抗體
xy-9247R    RNF111環(huán)指蛋白111抗體
xy-9255R    RNF121環(huán)指蛋白121抗體
xy-9259R    RNF169環(huán)指蛋白169抗體
xy-9248R    RNF113A環(huán)指蛋白113A抗體
xy-7007R    RNF43環(huán)指蛋白43抗體
xy-7006R    RASD2腫瘤血管內(nèi)皮標(biāo)記蛋白2抗體
xy-9159R    RNF14環(huán)指蛋白14抗體
xy-5816R    RRAGARAS相關(guān)GTP結(jié)合蛋白A抗體
xy-5805R    RIPK-1絲氨酸蘇氨酸激酶1受體相互作用蛋白抗體
xy-5815R    RAIDDCASP2凋亡相關(guān)蛋白抗體
xy-5940R    RAD54BDNA修復(fù)和重組蛋白R(shí)AD54B抗體
xy-5941R    RRAS2畸胎瘤癌基因RAS相關(guān)病毒抗體
xy-5954R    RASA3Ras-GTP酶激活蛋白3抗體
xy-11798R    Reticulon 1神經(jīng)內(nèi)分泌特異性蛋白抗體
xy-6214R    RDH11視黃醇脫氫酶11/丙型肝炎病毒核心蛋白抗體