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干燥癥SSB/La抗體

英文名稱 SSB
中文名稱 干燥癥SSB/La抗體
別    名 SSB; Lupus La protein homolog; La ribonucleoprotein; La autoantigen homolog; Sjogren syndrome type B antigen; LA_HUMAN.

說 明 書 0.2ml  
研究領(lǐng)域 免疫學(xué)  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 47kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human SSB
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
Lupus La protein (Sjogren syndrome type B antigen) (SS-B) (La ribonucleoprotein) (La autoantigen) plays a role in the transcription of RNA polymerase III. It is most probably a transcription termination factor. Binds to the 3' termini of virtually all nascent polymerase III transcripts. It is associated with precursor forms of RNA polymerase III transcripts including tRNA and 4.5S, 5S, 7S, and 7-2 RNAs. The phosphorylation sites are at the C-terminal part of the protein. Sera from patients with systemic lupus erythematosus(SLE) often contain antibodies that react with the normal cellular La protein as if this antigen was foreign.

Function:
Binds to the 3' poly(U) terminii of nascent RNA polymerase III transcripts, protecting them from exonuclease digestion and facilitating their folding and maturation.

Subunit:
Interacts with DDX15. May interact with RUFY1.xy-9030R    PAPSS2腺苷酸硫酸激酶2抗體
xy-9510R    PAR3蛋白酶激活受體3抗體
xy-9032R    PBLDMAWD結(jié)合蛋白抗體
xy-9033R    PCID1PCID1蛋白抗體
xy-9041R    PDZD6PDZ結(jié)構(gòu)域PDZK6蛋白抗體
xy-9035R    PDXK吡哆醛激酶抗體
xy-9036R    PDZK1PDZ結(jié)構(gòu)域PDZK1蛋白抗體
xy-9037R    PDZK3前列腺癌激活蛋白抗體
xy-9038R    PDZK4PDZ結(jié)構(gòu)域PDZK4蛋白抗體
xy-9042R    PDZD7PDZ結(jié)構(gòu)域PDZK7蛋白抗體
xy-9043R    PDZD8PDZ結(jié)構(gòu)域PDZK8蛋白抗體
xy-5613R    phospho-PTK9 (Tyr321)磷酸化蛋白酪氨酸激酶9抗體
xy-3865R    PRDX5+PRDX6過氧化還原酶5/6抗體
xy-3875R    PRDX1過氧化還原酶1抗體
xy-3912R    PNMT苯乙醇胺甲基轉(zhuǎn)移酶抗體
xy-2341R    PGF2 alpha前列腺素F2a/PGF2 α抗體
xy-7114R    PPAR gamma 2過氧化酶活化增生受體γ2抗體
xy-3866R    Protor-1乳腺癌抑制基因Protor1抗體
xy-6565R    POT1端粒保護蛋白1抗體
xy-6568R    PCANAP2前列腺癌相關(guān)蛋白2抗體
xy-6211R    PCMT1天門冬氨酸甲基轉(zhuǎn)移酶PCMT抗體
xy-6566R    PRSS3腦胰蛋白酶3抗體
xy-4169R    PTK9蛋白酪氨酸激酶9抗體
xy-15584R    PLAC8 胎盤特異基因8蛋白抗體
xy-2928R    PDLIM3輔肌動蛋白相關(guān)LIM蛋白抗體
xy-5784R    PROK2前動力蛋白2抗體
xy-5939R    PBOV1前列腺癌和乳腺癌高表達蛋白抗體
xy-5812R    PHLP腫瘤抑制基因PHLPP抗體
xy-5813R    PRODH脯氨酸脫氫酶抗體
xy-9365R    PSMD8蛋白酶調(diào)解因子8抗體
xy-5793R    Protein C inhibitor蛋白C抑制因子抗體
xy-5827R    PCDHGB5原鈣粘蛋白γB5抗體
xy-9354R    Proteasome 20S alpha 5蛋白酶體PSMα5抗體