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基質(zhì)細(xì)胞衍生因子－1抗體

英文名稱 SDF1 beta
中文名稱 基質(zhì)細(xì)胞衍生因子－1抗體
別    名 Chemokine (C X C motif) ligand 12; Chemokine (CXC motif) ligand 12; CXCL 12; CXCL12; hIRH; IRH; PBSF; Pre B cell growth stimulating factor; SCYB 12; SCYB12; SDF 1; SDF 1 beta; SDF 1a; SDF 1b; SDF1; SDF1a; SDF1b; Stromal cell derived factor 1; Stromal cell derived factor 1 beta; TLSF a; TLSF; TLSF b; TLSFa; TLSFb; TPAR 1; TPAR1.

說 明 書 0.1ml  0.2ml  
研究領(lǐng)域 細(xì)胞生物  免疫學(xué)  趨化因子  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, Chicken, Dog, Rabbit, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 8kDa
細(xì)胞定位 分泌型蛋白 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human SDF-1(32-62aa)
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
This gene encodes a stromal cell-derived alpha chemokine member of the intercrine family. The encoded protein functions as the ligand for the G-protein coupled receptor, chemokine (C-X-C motif) receptor 4, and plays a role in many diverse cellular functions, including embryogenesis, immune surveillance, inflammation response, tissue homeostasis, and tumor growth and metastasis. Mutations in this gene are associated with resistance to human immunodeficiency virus type 1 infections. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2013].

Function:
Chemoattractant active on T-lymphocytes, monocytes, but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. Also binds to another C-X-C chemokine receptor CXCR7, which activates the beta-arrestin pathway and acts as a scavenger receptor for SDF-1. SDF-1-beta(3-72) and SDF-1-alpha(3-67) show a reduced chemotactic activity. Binding to cell surface proteoglycans seems to inhibit formation of SDF-1-alpha(3-67) and thus to preserve activity on local sites. Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. Stimulates migration of monocytes and T-lymphocytes through its receptors, CXCR4 and CXCR7, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins. SDF1A/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through LYN kinase. Inhibits CXCR4-mediated infection by T-cell line-adapted HIV-1. Plays a protective role after myocardial infarction. Induces down-regulation and internalization of CXCR7 expressed in various cells.xy-3419R    Phospho-Smad2(Ser465 + Ser467)磷酸化細(xì)胞信號轉(zhuǎn)導(dǎo)分子SMAD2抗體
xy-3420R    Phospho-Smad2(Ser245 + Ser250 + Ser255)磷酸化細(xì)胞信號轉(zhuǎn)導(dǎo)分子SMAD2抗體
xy-2653R    SPHK2鞘氨醇激酶2抗體
xy-11485R    SPAG16精子相關(guān)蛋白16抗體
xy-2652R    SPHK1鞘氨醇激酶1抗體
xy-2617R    S100A13S100A13抗體
xy-2486R    SLAMF9CD2F-10抗體
xy-3509R    SCP3聯(lián)會復(fù)合體蛋白3抗體
xy-8503R    S100A10S100鈣結(jié)合蛋白A10抗體
xy-3428R    Phospho-Stat2 (Tyr690)磷酸化信號轉(zhuǎn)導(dǎo)和轉(zhuǎn)錄激活因子2抗體
xy-3429R    phospho-STAT3 (Ser727)磷酸化信號轉(zhuǎn)導(dǎo)和轉(zhuǎn)錄激活因子3抗體
xy-3430R    Phospho-Stat4 (Tyr693)磷酸化信號轉(zhuǎn)導(dǎo)和轉(zhuǎn)錄激活因子4抗體
xy-3431R    Phospho-Stathmin (Ser16)磷酸化原癌基因蛋白18抗體
xy-3432R    Phospho-Stathmin(Ser38)磷酸化原癌基因蛋白18抗體
xy-2018R    S6PDH6-磷酸山梨醇脫氫酶抗體
xy-8660R    Salmonella typhimurium O傷寒沙門氏菌體蛋白O抗原抗體
xy-8670R    Salmonella enteritidis H傷寒沙門氏菌鞭毛抗原H抗體
xy-12421R    14-3-3 gamma14-3-3γ抗體
xy-12422R    14-3-3 sigma14-3-3σ抗體
xy-12419R    14-3-3 Tau14-3-3τ蛋白抗體
xy-12420R    14-3-3 beta14-3-3β抗體
xy-2682R    SLAMF6SLAMF6抗體
xy-2675R    SPECAa-包襯蛋白抗體
xy-4025R    phospho-Syntaxin 1a(Ser14)磷酸化突觸融合蛋白1抗體
xy-4038R    SLC25A13線粒體內(nèi)鈣結(jié)合天冬氨酸/谷氨酸載體蛋白抗體
xy-4037R    SLC25A11線粒體二羧酸載體蛋白11抗體
xy-3839R    4EBP2eIF4E結(jié)合蛋白2抗體
xy-3765R    Serum Amyloid P血清淀粉樣蛋白P成份抗體
xy-11423R    Sox3轉(zhuǎn)錄因子Sox3抗體