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ZCH11蛋白抗體

英文名稱 ZCH11
中文名稱 ZCH11蛋白抗體
別    名 DKFZp779C1943; EC 2.7.7.52; FLJ42878; KIAA0191; PAP associated domain containing 3; PAPD3; Terminal uridylyltransferase 4; TUT4; TUT4_HUMAN; TUTase 4; ZCCHC 11; ZCCHC11; Zinc finger CCHC domain containing 11; Zinc finger CCHC domain containing protein 11; Zinc finger CCHC domain-containing protein 11.

說 明 書 0.2ml  
研究領(lǐng)域 細(xì)胞生物  轉(zhuǎn)錄調(diào)節(jié)因子  鋅指蛋白  表觀遺傳學(xué)  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Guinea Pig, Cat, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 185kDa
細(xì)胞定位 細(xì)胞核 細(xì)胞漿 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human ZCH11
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
ZCCHC11 is an RNA uridyltransferase (EC 2.7.7.52) that uses UTP to add uridines to the 3-prime end of substrate RNA molecules (Jones et al., 2009 [PubMed 19701194]).[supplied by OMIM, Jan 2011]

Function:
Uridylyltransferase that acts as a suppressor of microRNA (miRNA) biogenesis by specifically mediating the terminal uridylation of some miRNAs. Catalyzes the 3' uridylation of precursor let-7 (pre-let-7), a miRNA precursor. Uridylated pre-let-7 miRNAs fail to be processed by Dicer and undergo degradation. Degradation of pre-let-7 contributes to the maintenance of embryonic stem (ES) cells and is required for ES cells to maintain pluripotency. Does not bind RNA by itself, recruited to pre-let-7 miRNAs via its interaction with LIN28A and LIN28B. Also catalyzes the 3' uridylation of miR-26A, a miRNA that represses IL6 transcript, leading to abrogate IL6 transcript repression and promote cytokine expression. May also suppress Toll-like receptor-induced NF-kappa-B activity via binding to T2BP. Does not play a role in replication-dependent histone mRNA degradation.

Subcellular Location:
Nucleus. Cytoplasm. Translocates into the cytoplasm following treatment of the cell with LPS.

Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR.xy-0375R-FITxy    Rabbit Anti-Guinea pig IgM/FITCFITC標(biāo)記的兔抗豚鼠IgM
xy-0375R-Axy    Rabbit Anti-Guinea pig IgM/AP堿性磷酸酶（AP）標(biāo)記的兔抗豚鼠IgM
xy-0375R-Golxy    Rabbit Anti-Guinea pig IgM/Gold膠體金標(biāo)記的兔抗豚鼠IgM
xy-0375R-AF647    Rabbit Anti-Guinea pig IgM/Alexa Fluor 647Alexa Fluor 647標(biāo)記的兔抗豚鼠IgM
xy-0375R-Bio    Rabbit Anti-Guinea pig IgM/Bio生物素標(biāo)記的兔抗豚鼠IgM
xy-0375R-HRxy    Rabbit Anti-Guinea pig IgM/HRP辣根過氧化物酶標(biāo)記的兔抗豚鼠IgM
xy-0375R-xyy3    Rabbit Anti-Guinea pig IgM/Cy3Cy3標(biāo)記的兔抗豚鼠IgM
xy-0375R-xyy5    Rabbit Anti-Guinea pig IgM/Cy5Cy5標(biāo)記的兔抗豚鼠IgM
xy-0375R-Axyxy    Rabbit Anti-Guinea pig IgM/APCAPC標(biāo)記的兔抗豚鼠IgM
xy-0375R-AF350    Rabbit Anti-Guinea pig IgM/Alexa Fluor 350Alexa Fluor 350標(biāo)記的兔抗豚鼠IgM
xy-0375R-AF488    Rabbit Anti-Guinea pig IgM/Alexa Fluor 488Alexa Fluor 488標(biāo)記的兔抗豚鼠IgM
xy-0375R-AF555    Rabbit Anti-Guinea pig IgM/Alexa Fluor 555Alexa Fluor 555標(biāo)記的兔抗豚鼠IgM
xy-0308R-HRxy    Rabbit Anti-horse IgG/HRP辣根過氧化物酶標(biāo)記的兔抗馬IgG
xy-0308R-Bio    Rabbit Anti-horse IgG/Bio生物素標(biāo)記的兔抗馬IgG
xy-0308R-Axyxy    Rabbit Anti-horse IgG/APCAPC標(biāo)記的兔抗馬IgG
xy-0308R-AF350    Rabbit Anti-horse IgG/Alexa Fluor 350Alexa Fluor 350標(biāo)記的兔抗馬IgG
xy-0308R-AF488    Rabbit Anti-horse IgG/Alexa Fluor 488Alexa Fluor 488標(biāo)記的兔抗馬IgG
xy-0308R-AF555    Rabbit Anti-horse IgG/Alexa Fluor 555Alexa Fluor 555標(biāo)記的兔抗馬IgG
xy-0308R-AF647    Rabbit Anti-horse IgG/Alexa Fluor 647Alexa Fluor 647標(biāo)記的兔抗馬IgG
xy-0308R-xyE-xyy5.5    Rabbit Anti-horse IgG/PE-Cy5.5PE-Cy5.5標(biāo)記的兔抗馬IgG
xy-0308R-xyE-xyy7    Rabbit Anti-horse IgG/PE-Cy7PE-Cy7標(biāo)記的兔抗馬IgG
xy-0308R-Axy    Rabbit Anti-horse IgG/AP堿性磷酸酶（AP）標(biāo)記的兔抗馬IgG
xy-0308R-Golxy    Rabbit Anti-horse IgG/Gold膠體金標(biāo)記的兔抗馬IgG
xy-0308R-FITxy    Rabbit Anti-horse IgG/FITCFITC標(biāo)記的兔抗馬IgG
xy-0308R-RBITxy    Rabbit Anti-horse IgG/RBITC羅丹明標(biāo)記的兔抗馬IgG
xy-0308R-xyE-xyY5    Rabbit Anti-horse IgG/PE-CY5PE-CY5標(biāo)記的兔抗馬IgG
xy-0308R-xyy3    Rabbit Anti-horse IgG/Cy3Cy3標(biāo)記的兔抗馬IgG
xy-0308R-xyy5    Rabbit Anti-horse IgG/Cy5Cy5標(biāo)記的兔抗馬IgG
xy-0308R-xyy5.5    Rabbit Anti-horse IgG/Cy5.5Cy5.5標(biāo)記的兔抗馬IgG
xy-0308R-xyy7    Rabbit Anti-horse IgG/Cy7Cy7標(biāo)記的兔抗馬IgG
xy-0308R-xyE    Rabbit Anti-horse IgG/PEPE標(biāo)記的兔抗馬IgG
xy-0297R-RBITxy    Rabbit Anti-human IgG/RBITC羅丹明標(biāo)記的兔抗人IgG
xy-0297R-Golxy    Rabbit Anti-human IgG/Gold膠體金標(biāo)記的兔抗人IgG
xy-0297R-Axy    Rabbit Anti-human IgG/AP堿性磷酸酶（AP）標(biāo)記的兔抗人IgG