ZNHIT3蛋白抗體 返回列表頁

ZNHIT3蛋白抗體

英文名稱 ZNHIT3
中文名稱 ZNHIT3蛋白抗體
別    名 HNF 4a coactivator; Thyroid hormone receptor interactor 3; Thyroid receptor interacting protein 3; TR interacting protein 3; TRIP 3; ZNHI3_HUMAN; TRIP3; Zinc finger HIT domain containing protein 3; Zinc finger HIT type 3; Zinc finger, HIT domain containing 3; Zinc finger, HIT type containing 3.

說 明 書 0.2ml  
研究領(lǐng)域 細胞生物  轉(zhuǎn)錄調(diào)節(jié)因子  鋅指蛋白  表觀遺傳學  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human, Mouse, Rat, Rabbit, 
產(chǎn)品應用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 18kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human ZNHIT3
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20℃. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4℃.

PubMed PubMed
產(chǎn)品介紹 background:
ZNHIT3 is a 155 amino acid protein that contains one HIT-type zinc finger and regulates PPAR?mediated adipocyte differentiation. ZNHIT3 also coactivates HNF-4? and as a thyroid receptor interacting protein, ZNHIT3 interacts with the ligand binding domain of the thyroid receptor. The gene encoding ZNHIT3 maps to human chromosome 17, which comprises over 2.5% of the human genome and encodes over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. Like p53, BRCA1 is directly involved in DNA repair, though specifically it is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes.

Function:
ZNHIT3 functions as a transcriptional coactivator and contains 1 HIT type zinc finger.

Subunit:
Thyroid receptor interacting proteins (TRIPs) specifically interact with the ligand binding domain of the thyroid receptor (TR). Requires the presence of thyroid hormone for its interaction.

Similarity:
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