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鋅指蛋白131抗體

英文名稱 ZNF131
中文名稱 鋅指蛋白131抗體
別    名 pHZ 10; pHZ10; Zinc finger protein 131; ZN131_HUMAN; ZNF 131; Znf131.

說 明 書 0.2ml  
研究領(lǐng)域 神經(jīng)生物學(xué)  轉(zhuǎn)錄調(diào)節(jié)因子  鋅指蛋白  表觀遺傳學(xué)  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Sheep, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 71kDa
細胞定位 細胞核 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from Human ZNF131
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 癈 for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20癈. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 癈.

PubMed PubMed
產(chǎn)品介紹 background:
Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. The majority of zinc-finger proteins contain a Kruppel-type DNA binding domain and a KRAB domain, which is thought to interact with KAP1, thereby recruiting histone modifying proteins. As a member of the krueppel C2H2-type zinc-finger protein family, ZNF131 (Zinc finger protein 131) is a 623 amino acid nuclear protein that contains one BTB (POZ) domain and six C2H2-type zinc fingers. With predominant expression found in brain, it is likely that ZNF131 plays a role as a transcription regulator during development and organogenesis of the adult central nervous system. ZNF131 also represses ER Alpha (Estrogen receptor alpha)-mediated transactivation by interrupting ER?binding to the estrogen-response element. There are two isoforms of ZNF131 that are produced as a result of alternative splicing events.

Function:
May be involved in transcriptional regulation. Plays a role during development and organogenesis as well as in the function of the adult central nervous system.

Subcellular Location:
Nucleus.

Tissue Specificity:
Predominant expression is found in different brain areas such as the occipital and temporal lobe, the nucleus caudatus, hippocampus, and the cerebellum as well as in testis and thymus.

Post-translational modifications:
Sumoylation by CBX4 at Lys-601 by may potentiate the negative effect on estrogen signaling.xy-0303Rs    Rabbit anti-Dog IgG whole serum兔抗狗IgG抗血清
xy-0370Rs    Rabbit anti-Goat IgM whole serum兔抗羊IgM抗血清
xy-0358Rs    Rabbit anti-Guinea pig IgG whole serum兔抗豚鼠IgG抗血清
xy-0375Rs    Rabbit anti-Guinea pig IgM whole serum兔抗豚鼠IgM抗血清
xy-0297Rs    Rabbit anti-human IgG whole serum兔抗人IgG抗血清
xy-0345Rs    Rabbit anti-human IgM whole serum兔抗人IgM抗血清
xy-0335Rs    Rabbit anti-Monkey IgG whole serum兔抗猴IgG抗血清
xy-0336Rs    Rabbit anti-Monkey IgM whole serum兔抗猴IgM抗血清
xy-0296Rs    Rabbit anti-mouse IgG whole serum兔抗小鼠IgG抗血清
xy-0368Rs    Rabbit anti-mouse IgM whole serum兔抗小鼠IgM抗血清
xy-0330Rs    Rabbit anti-mouse Kappa Chain whole serum兔抗小鼠k-鏈抗血清
xy-0377Rs    Rabbit anti-mouse IgG-Fc fragment whole serum兔抗小鼠IgG-Fc段抗血清
xy-0403Rs    Rabbit anti-MG IgG whole serum兔抗長爪沙鼠IgG抗血清
xy-0297xys    Donkey anti-human IgG whole serum驢抗人IgG抗血清
xy-0294xys    Donkey anti-Goat IgG whole serum驢抗羊IgG抗血清
xy-0358xys    Donkey anti-Gpig IgG whole serum驢抗豚鼠IgG抗血清
xy-0326Gs    Goat anti-Bovine IgG whole serum羊抗牛IgG抗血清
xy-0326Rs    Rabbit anti-Bovine IgG whole serum兔抗牛IgG抗血清
xy-0326G    Goat Anti-Bovine IgG羊抗牛IgG
xy-0326M    Mouse Anti-Bov IgG小鼠抗牛IgG
xy-0326R    Rabbit Anti-Bov IgG兔抗牛IgG
xy-0310G    Goat Anti-Chicken IgG羊抗雞IgG
xy-0310R    Rabbit Anti-chicken IgG兔抗雞IgG
xy-0432M    chicken IgY小鼠抗雞IgY抗體
xy-0373R    Dog IgM兔抗犬IgM抗體
xy-0296G    Goat Anti-Mouse IgG羊抗小鼠IgG
xy-0294xy    Donkey Anti-Goat IgG驢抗羊IgG
xy-0295G    Goat Anti-rabbit IgG羊抗兔IgG
xy-0294R    Rabbit Anti-Goat IgG兔抗羊IgG
xy-0294Rs    Rabbit anti-Goat IgG whole serum兔抗羊IgG抗血清
xy-0358M    Mouse Anti-Guinea pig IgG小鼠抗豚鼠IgG
xy-0308Rs    Rabbit anti-horse IgG whole serum兔抗馬IgG抗血清
xy-0297M    Mouse Anti-human IgG小鼠抗人IgG