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XRN1蛋白抗體

英文名稱 XRN1
中文名稱 XRN1蛋白抗體
別    名 Dhm2; mXRN1; XRN1_HUMAN; SEP1; Strand-exchange protein 1 homolog.

說 明 書 0.2ml  
研究領域 細胞生物  轉(zhuǎn)錄調(diào)節(jié)因子  表觀遺傳學  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human, 
產(chǎn)品應用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 193kDa
細胞定位 細胞核 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human XRN1
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
This gene encodes a member of the 5'-3' exonuclease family. The encoded protein may be involved in replication-dependent histone mRNA degradation, and interacts directly with the enhancer of mRNA-decapping protein 4. In addition to mRNA metabolism, a similar protein in yeast has been implicated in a variety of nuclear and cytoplasmic functions, including homologous recombination, meiosis, omere maintenance, and microtubule assembly. Mutations in this gene are associated with osteosarcoma, suggesting that the encoded protein may also play a role in bone formation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

Function:
Xrn1 is the major 5'-3' exoribonuclease involved in mRNA decay. Required for the 5'-3'processing of the G4 tetraplex-containing DNA and RNA substrates. The kinetic of hydrolysis is faster for G4 RNA tetraplex than for G4 DNA tetraplex and monomeric RNA tetraplex. Binds to RNA and DNA (By similarity). May act as a tumor suppressor protein in osteogenic sarcoma (OGS). Associates with alpha and beta tubulins (By similarity). Found in a mRNP complex with RENT1, RENT2, RENT3B and XRN1. xy-8048R    KLHL21Kelch樣蛋白21抗體
xy-8051R    KLHL25Kelch樣蛋白25抗體
xy-11026R    Kinesin驅(qū)動蛋白KNS1抗體
xy-11033R    KIF1B驅(qū)動蛋白家族成員1B抗體
xy-7851R    katanin p80劍蛋白p80抗體
xy-6435R    KIRREL1腎病樣蛋白1抗體
xy-11670R    SETDB1組蛋白H3K9甲基轉(zhuǎn)移酶4抗體
xy-11661R    KCNE3鉀離子通道蛋白家族成員3抗體
xy-6947R    Keratin82角蛋白82抗體
xy-9696R    C20orf1920號染色體開放閱讀框19抗體
xy-11054R    Keratocan細胞角膜蛋白多糖抗體
xy-9560R    KRCC1含賴氨酸卷曲螺旋蛋白1抗體
xy-4812R    Prostate Specific Antigen激肽釋放酶3/舒血管素3抗體
xy-9526R    KLF1, 2, 4上皮鋅指蛋白1, 2, 4抗體
xy-1064R    KLF4腸道內(nèi)富含的Kruppel樣因子/上皮鋅指蛋白4抗體
xy-3549R    KSR1Ras信號轉(zhuǎn)導KSR1蛋白抗體
xy-0225M    KLH血藍蛋白抗體
xy-8546R    KRIT1腦海綿狀血管畸形蛋白1抗體
xy-9716R    KBPKBP蛋白抗體
xy-1094R    kappa Opioid receptorkappa型阿片受體抗體
xy-7688R    Kininogen-1 heavy chain激肽原1重鏈抗體
xy-7689R    KCNMB1鈣激活鉀通道蛋白β1抗體
xy-9442R    Kv4.2電壓門控性鉀通道蛋白Kv4.2抗體
xy-9443R    phospho-Kv4.2(Thr602)磷酸化電壓門控性鉀通道蛋白Kv4.2抗體
xy-9444R    phospho-Kv4.2(Thr607)磷酸化電壓門控性鉀通道蛋白Kv4.2抗體
xy-2112R    KT3 tagKT3 tag抗體
xy-1963R    KLK1激肽釋放酶1抗體
xy-1964R    KLK3激肽釋放酶3/舒血管素3抗體
xy-1965R    KLK4激肽釋放酶4抗體
xy-9118R    KMT1C組蛋白H3賴氨酸9甲基化1C抗體