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腎母細(xì)胞瘤蛋白抗體

英文名稱 Wilms Tumor Protein
中文名稱 腎母細(xì)胞瘤蛋白抗體
別    名 WIT 2; WT 1; AWT1; FWT1; GUD; NPHS4; WAGR; Wilms tumor 1; Wilms Tumor; Wilms tumor protein; Wilms' tumor gene; Wilms' tumor protein; WIT2; WT; WT1; WT-1; WT1_HUMAN; WT33.
 
說(shuō) 明 書 0.1ml  0.2ml  
研究領(lǐng)域 腫瘤  細(xì)胞生物  免疫學(xué)  發(fā)育生物學(xué)  腫瘤細(xì)胞生物標(biāo)志物  表觀遺傳學(xué)  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Sheep, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 55kDa
細(xì)胞定位 細(xì)胞核 細(xì)胞漿 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human Wilms Tumor Protein
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
Transcription factor that plays an important role in cellular development and cell survival. Regulates the expression of numerous target genes, including EPO. Plays an essential role for development of the urogenital system. Recognizes and binds to the DNA sequence 5'-CGCCCCCGC-3'. It has a tumor suppressor as well as an oncogenic role in tumor formation. Function may be isoform-specific: isoforms lacking the KTS motif may act as transcription factors. Isoforms containing the KTS motif may bind mRNA and play a role in mRNA metabolism or splicing. Isoform 1 has lower affinity for DNA, and can bind RNA.

Function:
Transcription factor that plays an important role in cellular development and cell survival. Regulates the expression of numerous target genes, including EPO. Plays an essential role for development of the urogenital system. Recognizes and binds to the DNA sequence 5'-CGCCCCCGC-3'. It has a tumor suppressor as well as an oncogenic role in tumor formation. Function may be isoform-specific: isoforms lacking the KTS motif may act as transcription factors. Isoforms containing the KTS motif may bind mRNA and play a role in mRNA metabolism or splicing. Isoform 1 has lower affinity for DNA, and can bind RNA.

Subunit:
Homodimer. Interacts with WTIP. Interacts with actively translating polysomes. Detected in nuclear ribonucleoprotein (mRNP) particles. Interacts with HNRNPU via the zinc-finger region. Interacts with U2AF2. Interacts with CITED2. Interacts with ZNF224 via the zinc-finger region. Interacts with WTAP and SRY. Interacts with FAM123B/WTX. Interacts with RBM4xy-4186R    MIG5細(xì)胞遷移誘導(dǎo)因子5抗體
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xy-13654R    MAP4K5絲裂原活化蛋白激酶MAP4K5抗體
xy-13655R    MKLN1MKLN1抗體
xy-13688R    MAP2K1IP1絲裂原活化蛋白激酶相互作用蛋白1抗體
xy-13689R    MPP2MPP2蛋白抗體
xy-13690R    MS4A14睪丸發(fā)育相關(guān)蛋白抗體
xy-13691R    MS4A15MS4A15蛋白抗體
xy-13692R    MS4A6A四度跨膜蛋白3抗體
xy-6818R    MAGEA12黑色素瘤相關(guān)抗原12抗體
xy-6819R    MAGEA2黑色素瘤相關(guān)抗原2抗體
xy-6820R    MAGEA5黑色素瘤相關(guān)抗原5抗體
xy-10158R    Msx2同源盒基因Msx2抗體
xy-5470R    Phospho-MDM2(Thr218)磷酸化雙微體2癌基因抗體
xy-5471R    Phospho-MDM2(Ser186)磷酸化雙微體2癌基因抗體
xym-2182M    Melamine(1B12)三聚氰胺單克隆抗體
xy-6821R    MAGEB1黑色素瘤相關(guān)抗原B1抗體
xy-2721R    MCM5微小染色體維持缺陷蛋白5抗體
xy-4293R    MACC1結(jié)腸癌轉(zhuǎn)移相關(guān)蛋白1抗體
xy-4597R    MMP-1基質(zhì)金屬蛋白酶-1抗體
xy-5483R    phospho-MEF2C(Thr300)磷酸化肌細(xì)胞增強(qiáng)因子2C抗體
xy-5485R    Phospho-MEF2A(Thr319)磷酸化肌細(xì)胞增強(qiáng)因子2抗體
xy-5474R    phospho-MBP(Thr232)磷酸化髓鞘堿性蛋白抗體
xy-5475R    phospho-MBP(Tyr203)磷酸化髓鞘堿性蛋白抗體
xy-5478R    phospho-MYL6(Tyr29+Ser30)磷酸化肌球蛋白輕鏈6抗體
xy-5476R    phospho-P38 MAPK (Thr180)磷酸化p38MAPK抗體
xy-5477R    phospho-p38 MAPK (Tyr323)磷酸化p38MAPK抗體
xy-5480R    phospho-MEF2C(Ser396)磷酸化肌細(xì)胞增強(qiáng)因子2C抗體
xy-5487R    phospho-MAPK8 ( Thr183 + Tyr185)磷酸化氨基末端激酶2抗體
xy-12201R    MELK蛋白激酶MPK38抗體
xy-12206R    MGST1微粒體谷胱甘肽S轉(zhuǎn)移酶1抗體
xy-10074R    MUC13粘蛋白13抗體