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WASP結(jié)合蛋白抗體

英文名稱 WIPF2
中文名稱 WASP結(jié)合蛋白抗體
別    名 WAS/WASL interacting protein family member 2; WASP binding protein; WASP interacting protein related protein; WICH; WIP and CR16 homologous protein; WIP related protein; WIPF 2; WIR; WIPF2_HUMAN.
  
說 明 書 0.2ml  
研究領(lǐng)域 心血管  信號(hào)轉(zhuǎn)導(dǎo)  細(xì)胞骨架  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, Dog, Pig, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 46kDa
細(xì)胞定位 細(xì)胞漿 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human WIPF2
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
WIRE, also known as WIPF2 (WAS/WASL interacting protein family, member 2) or WICH, is a 440 amino acid protein that localizes to both the cytoplasm and the cytoskeleton and contains one WH2 domain. Expressed ubiquitously with highest expression in colon, brain, lung and stomach, WIRE functions as an N-WASP-interacting protein that plays an important role in the organization and mobilization of the Actin cytoskeleton. Additionally, WIRE is involved in the formation of cell surface protrusions and may also provide a link between the cytoskeletal machinery and PDGF-B receptors. Multiple alternatively spliced isoforms of WIRE exist and are encoded by a gene that maps to human chromosome 17.

Function:
Plays an active role in the formation of cell surface protrusions downstream of activated PDGFB receptors. Plays an important role in actin-microspike formation through cooperation with WASL. May cooperate with WASP and WASL to induce mobilization and reorganization of the actin filament system. xy-5763R    MRP9多藥耐藥相關(guān)蛋白9抗體
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xy-9610R    MYH9肌球蛋白重鏈9抗體
xy-8562R    MLLT11髓系/淋巴或混合型白血病11抗體
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xy-0761R    Midnolin中腦核仁蛋白抗體
xy-9862R    MYH7B肌球蛋白重鏈7抗體
xy-9863R    MYOM1肌間蛋白1抗體
xy-9864R    MYOM2肌間蛋白2抗體
xy-9865R    MYLK3肌球蛋白輕鏈激酶3抗體
xy-9866R    MYLK2肌球蛋白輕鏈激酶2抗體
xy-6781R    MAP3K10絲裂原活化蛋白激酶3K10抗體
xy-6782R    MST4絲氨酸/蘇氨酸蛋白激酶MST4抗體
xy-7761R    Myosin VIIa肌球蛋白7a/常染色體隱性耳聾蛋白2抗體
xy-8084R    MBC1膀胱癌突變蛋白1抗體
xy-9376R    MURF3肌肉特定環(huán)指蛋白3抗體
xy-9377R    EDPF1腸細(xì)胞分化相關(guān)因子1抗體
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