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信號(hào)通路Wnt16抗體

英文名稱(chēng) Wnt16
中文名稱(chēng) 信號(hào)通路Wnt16抗體
別    名 Protein Wnt 16 precursor; Protein Wnt-16; Wingless type MMTV integration site family member 16; WNT16; WNT16_HUMAN.
  
說(shuō) 明 書(shū) 0.2ml  
研究領(lǐng)域 腫瘤  免疫學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  轉(zhuǎn)錄調(diào)節(jié)因子  糖蛋白  
抗體來(lái)源 Rabbit
克隆類(lèi)型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, Pig, Cow, Rabbit, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 37kDa
細(xì)胞定位 細(xì)胞外基質(zhì) 分泌型蛋白 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human Wnt16
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
The Wnt genes encode a family of secreted extracellular signaling glycoproteins, which function in a variety of important developmental processes such as regulation of cell growth and differentiation. Wnt proteins also play roles in carcinogenesis. Wnt-14, rather than Wnt-15, is preferentially expressed in various types of human cancer. Wnt-15 is expressed in fetal and adult kidney and is most homologous to Wnt-14. Wnt-16, another member in the Wnt family, has two mRNA isoforms, Wnt-16a and Wnt-16b. These isoforms differ in the composition of their 5'UTR and first exon, which results in differential expression. Wnt-16a is expressed only in pancreas, whereas Wnt-16b is highly expressed in adult kidney, placenta, brain, heart and spleen, but not in bone marrow. However, Wnt-16 transcripts are present in bone marrow and cell lines derived from pre-B acute lymphoblastoid leukemia patients carrying the E2A-Pbx1 hybrid gene. Thus, Wnt-16 is a downstream target of E2A-Pbx1, and the Wnt-16-mediated autocrine growth mechanism may contribute to the development of t(1;19) pre-B acute lymphoblastoid leukemias.

Function:
Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters xy-1101R    MCP1單核細(xì)胞趨化蛋白1抗體
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xy-0815R    Megsin絲氨酸蛋白酶抑制劑B7抗體
xy-0557R    Mfn1線粒體融合蛋白1抗體
xy-1002R    MGMTO6甲基鳥(niǎo)嘌呤DNA甲基轉(zhuǎn)移酶抗體
xy-6473R    MUSK肌肉骨骼受體酪氨酸激酶抗體
xy-9268R    Mycobacterium tuberculosis Ag85B結(jié)核分枝桿菌抗體
xy-9335R    MARCH1膜相關(guān)環(huán)指蛋白1抗體
xy-9336R    MARCH2膜相關(guān)環(huán)指蛋白2抗體
xy-9337R    MARCH3膜相關(guān)環(huán)指蛋白3抗體
xy-9341R    MARCH7膜相關(guān)環(huán)指蛋白7抗體
xy-9342R    MARCH8膜相關(guān)環(huán)指蛋白8抗體
xy-9343R    MARCH9膜相關(guān)環(huán)指蛋白9抗體
xy-0101M    M2-PK (pyruvate Kinase M2)丙酮酸激酶-M2
xy-0300R    Mesothelin間皮素抗體
xy-0424R    MMP-1基質(zhì)金屬蛋白酶-1抗體
xy-0463R    MMP-1基質(zhì)金屬蛋白酶-1抗體
xy-0575R    MMP13基質(zhì)金屬蛋白酶13抗體
xy-0414R    MMP-14基質(zhì)金屬蛋白酶-14抗體
xy-0412R    MMP2基質(zhì)金屬蛋白酶2抗體
xy-0413R    MMP-3基質(zhì)金屬蛋白酶3抗體
xy-0423R    MMP-7基質(zhì)金屬蛋白酶-7抗體
xy-0397R    MMP9基質(zhì)金屬蛋白酶-9抗體
xy-0426R    MOG髓鞘少樹(shù)突膠質(zhì)細(xì)胞糖蛋白抗體
xy-0657R    MRP1多藥耐藥相關(guān)蛋白1抗體
xy-1092R    MRP2多藥耐藥相關(guān)蛋白2抗體
xy-0656R    MRP3多藥耐藥相關(guān)蛋白3抗體
xy-0818R    MrpL28線粒體核糖體蛋白L28抗體
xy-0758R    MSH2錯(cuò)配修復(fù)蛋白2抗體
xy-9450R    5 MethylCytosine5甲基胞嘧啶抗體
xy-7175R    MAL2T淋巴細(xì)胞分化蛋白MAL2抗體
xy-9378R    RNF61環(huán)指蛋白61抗體
xy-1289R    Muscarinic Acetylcholine receptor M3毒蕈堿型乙酰膽堿受體M3抗體
xy-0836R    MLH1錯(cuò)配修復(fù)蛋白1抗體
xy-6076R    Angiotensin II Type 2 Receptor血管緊張素Ⅱ2型受體相互作用蛋白抗體
xy-2659R    MARCO巨噬細(xì)胞清道夫受體抗體
xy-2161R    Myf6生肌調(diào)節(jié)因子6抗體
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xym-2129M    Morphine(2F11)嗎啡單克隆抗體