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Wnt1信號通路蛋白3抗體

英文名稱 WISP3
中文名稱 Wnt1信號通路蛋白3抗體
別    名 CCN 6; CCN family member 6; CCN6; CYR61; LIBC; Lost in inflammatory breast cancer tumor suppressor protein; MGC125987; MGC125988; MGC125989; OTTHUMP00000040421; PPAC; PPD; UNQ462/PRO790/PRO956; WISP 3; WISP-3; WISP3; WISP3_HUMAN; WNT 1 inducible signaling pathway protein 3; Wnt 1 signaling pathway protein 3; WNT1 inducible signaling pathway protein 3; WNT1 inducible signaling pathway protein 3 precursor; WNT1-inducible-signaling pathway protein 3.

說 明 書 0.1ml  0.2ml  
研究領(lǐng)域 腫瘤  細胞生物  發(fā)育生物學  信號轉(zhuǎn)導  干細胞  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, Dog, Horse, Rabbit, Sheep, Monkey, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 37kDa
細胞定位 分泌型蛋白 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human WISP3
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
Wnt-induced secreted protein (WISP)-1, WISP-2 and WISP-3 are members of the CCN family of growth factors, which include connective tissue growth factor (CTGF) and Cyr61. WISP-1, WISP-2 and WISP-3 share significant sequence similarity, including four conserved cysteine-rich domains, and they are believed to function as dimers in their active forms. WISP-1 expression is observed in various tissues including adult heart, kidney and spleen, while WISP-2 expression predominates in skeletal muscle, colon and ovary. Both WISP-1 and WISP-2 are upregulated in cells transformed with the proto-oncogene Wnt-1, and they are also more highly expressed in human colon tumors, suggesting that these proteins may participate in tumor development. WISP-3 is involved in normal post-natal skeletal growth, and it is also implicated in the development of the autosomal recessive skeletal disorder progressive pseudorheumatoid dysplasia, which affects cartilage homeostasis by disrupting the growth of chondrocyte and normal cell columnar organization. 

Function:
Appears to be required for normal postnatal skeletal growth and cartilage homeostasis.

Subcellular Location:
Secreted.xy-1237R    MGLUR3代謝型谷氨酸受體-3抗體
xy-1162R    CXCL2巨噬細胞炎癥蛋白2（ GRＯβ）抗體
xy-1328R    Metallothionein金屬硫蛋白抗體
xy-3259R    Phospho-MAP2(Ser136)磷酸化微管相關(guān)蛋白2抗體
xy-9899R    MMRN1內(nèi)皮細胞MMRN1蛋白抗體
xy-3270R    Phospho-MEK1/2 (Ser218 + Ser222)磷酸化絲裂原活化蛋白激酶激酶1/2抗體
xy-3271R    Phospho-Met (c-Met) (Tyr1003)磷酸化肝細胞生長因子受體(原癌基因)抗體
xy-3272R    Phospho-Met (Tyr1234 + Tyr1235)磷酸化肝細胞生長因子受體(原癌基因)抗體
xy-3265R    Phospho-Mcl1 (Ser159 + Thr163)磷酸化髓樣細胞白血病-1抗體
xy-3266R    Phospho-MDM2 (Ser166)磷酸化雙微體2癌基因抗體
xy-3267R    Phospho-MEF2A (Thr312)磷酸化肌細胞增強因子2抗體
xy-3268R    Phospho-MEF2A (Ser408)磷酸化肌細胞增強因子2抗體
xy-3269R    phospho-MEK1 (Thr286)磷酸化絲裂原活化蛋白激酶激酶1抗體
xy-3260R    Phospho-MAP2 (Thr1620 + Thr1623)磷酸化微管相關(guān)蛋白2抗體
xy-2908R    MAPKAP Kinase 2絲裂原活化蛋白激酶活化的蛋白激酶2抗體
xy-3261R    Phospho-MAPKAPK2 (Thr222)磷酸化絲裂原活化蛋白激酶活化的蛋白激酶2抗體
xy-3262R    Phospho-MAPKAPK2(Thr334)磷酸化絲裂原活化蛋白激酶活化的蛋白激酶2抗體
xy-3263R    Phospho-MARCKS (Ser152 + Ser156)磷酸化丙氨酸蛋白激酶C底物Marcks抗體
xy-3359R    Phospho-MARCKS (Ser162)磷酸化丙氨酸蛋白激酶C底物Marcks抗體
xy-0668R    Met (c Met)肝細胞生長因子受體抗體
xy-6779R    phospho-MAP3K9+MAP3K10(Thr312 + Thr266)磷酸化絲裂原活化蛋白激酶3K9抗體
xy-6780R    TYRO3受體酪氨酸激酶抗體
xy-6778R    MAP3K9絲裂原活化蛋白激酶3K9抗體
xy-7558R    MC3 Receptor黑素皮質(zhì)素3受體抗體
xy-1988R    MeninMenin抑癌蛋白抗體
xy-8542R    MSH3錯配修復蛋白3抗體
xy-1983R    MCM7微小染色體維持缺陷蛋白7抗體
xy-1985R    MCP-2單核細胞趨化蛋白2抗體(小鼠)
xy-1986R    MCP-3單核細胞趨化蛋白3抗體
xy-1987R    MCP-3單核細胞趨化蛋白3抗體
xy-1989R    MIP4巨噬細胞炎癥蛋白18抗體
xy-1990R    MITFMITF相關(guān)轉(zhuǎn)錄因子抗體
xy-1992R    MTOR雷帕霉素靶蛋白抗體
xy-1993R    Muc2粘蛋白-2/上皮膜抗原2抗體
xy-1994R    Mucin 4粘蛋白4抗體
xy-0924R    Mafav-maf 肌腱膜纖維肉瘤癌基因同源物A抗體
xy-1344R    MMP-10基質(zhì)金屬蛋白酶-10抗體
xy-0913R    Mtp53(N235K N239Y)突變型P53抗體