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WTX蛋白抗體

英文名稱 WTX
中文名稱 WTX蛋白抗體
別    名 FAM123B; AMER1; FAM 123B; AMER1_HUMAN; Family with sequence similarity 123B; FLJ39827; OSCS; Protein FAM123B; RP11 403E24.2; Wilms tumor gene on the X chromosome protein; Wilms tumor on the X; WTX.
  
說 明 書 0.2ml  
研究領(lǐng)域 腫瘤  細(xì)胞生物  信號(hào)轉(zhuǎn)導(dǎo)  干細(xì)胞  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, Cow, Horse, Sheep, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 124kDa
細(xì)胞定位 細(xì)胞漿 細(xì)胞膜 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human WTX
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
The protein encoded by this gene upregulates trancriptional activation by the Wilms tumor protein and interacts with many other proteins, including CTNNB1, APC, AXIN1, and AXIN2. Defects in this gene are a cause of osteopathia striata with cranial sclerosis (OSCS). [provided by RefSeq, May 2010]

Function:
FAM123B enhances trancription activation by WT1. It also promotes CTNNB1 ubiquitination and degradation and antagonizes Wnt and CTNNB1 signaling. FAM123B is involved in kidney development.

Subcellular Location:
Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus. Note: Shuttles between nucleus and cytoplasm. Detected in nuclear paraspeckles that are found close to splicing speckles.

Gene ID:
139285

Database links:

Entrez Gene: 139285 Human

Entrez Gene: 72345 Mouse

Omim: 300647 Human

SwissProt: Q5JTC6 Human

SwissProt: Q7TS75 Mousexy-0070R    NKB神經(jīng)激肽B抗體
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xy-0289R    Neurofascin神經(jīng)束蛋白抗體
xy-0708R    NF-H高分子量神經(jīng)絲蛋白抗體
xy-0465R    NFKB p65細(xì)胞核因子/k基因結(jié)合核因子抗體
xy-0707R    NF-L低分子量神經(jīng)絲蛋白抗體
xy-0710R    NF-M中分子量神經(jīng)絲蛋白抗體
xy-6390R    Necdin生長抑制蛋白NDN抗體
xy-0067R    NGFB神經(jīng)生長因子β抗體
xy-1065R    C9orf127鼻咽癌細(xì)胞相關(guān)基因6抗體
xy-0505R    Sodium / Hydrogen Exchanger 1鈉氫通道蛋白抗體
xy-7694R    SLC12A3鈉氯離子轉(zhuǎn)運(yùn)蛋白抗體
xy-1027R    NSE神經(jīng)元特異性烯醇化酶/γ 烯醇化酶抗體
xy-0160R    Neurotrophin 3神經(jīng)營養(yǎng)因子-3前蛋白抗體
xy-0178R    Nurr1核受體相關(guān)因子-1抗體
xy-1074R    Nrf2核因子2相關(guān)因子2抗體
xy-0693R    Neuropilin 1神經(jīng)纖毛蛋白1抗體
xy-0158R    Neurotrophin 4神經(jīng)生長因子4/5抗體
xy-9717R    Nidogen 2巢蛋白NID2抗體
xy-9712R    NHEDC2線粒體鈉/氫交換蛋白質(zhì)2抗體
xy-8570R    Neurogenin 1神經(jīng)元素1抗體
xy-0071R    Neuropeptide Y神經(jīng)肽Y抗體
xy-0073R    Neurturin神經(jīng)營養(yǎng)因子抗體
xy-0222R    NMDAR2B谷氨酸受體2B抗體
xy-0694R    Neuropilin 2神經(jīng)纖毛蛋白2抗體
xy-1072R    NR2D谷氨酸受體2D抗體
xy-1146R    NRAS原癌基因N-Ras抗體
xy-6461R    NF-ATc4T細(xì)胞激活核轉(zhuǎn)錄因子4抗體
xy-8588R    NETO1腦低密度脂蛋白受體蛋白1抗體
xy-11104R    Neurexin 2軸突蛋白2抗體
xy-4866R    Nephrin腎小球細(xì)胞粘附分子受體抗體