細(xì)胞核轉(zhuǎn)錄因子X盒結(jié)合蛋白抗體 返回列表頁

細(xì)胞核轉(zhuǎn)錄因子X盒結(jié)合蛋白抗體

英文名稱 XBP1
中文名稱 細(xì)胞核轉(zhuǎn)錄因子X盒結(jié)合蛋白抗體
別    名 X box-binding protein-1; XBP-1; XBP1; XBP2; Tax responsive element binding protein 5; TREB5; X box binding protein 2; XBP 1; XBP2; XBP1_HUMAN.
  
說 明 書 0.1ml  0.2ml  
研究領(lǐng)域 轉(zhuǎn)錄調(diào)節(jié)因子  表觀遺傳學(xué)  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, Chicken, Pig, Cow, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 29kDa
細(xì)胞定位 細(xì)胞核 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human XBP-1 (51-90aa)
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
This gene encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. This gene product is a bZIP protein, which was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator. It has been found that upon accumulation of unfolded proteins in the endoplasmic reticulum (ER), the mRNA of this gene is processed to an active form by an unconventional splicing mechanism that is mediated by the endonuclease inositol-requiring enzyme 1 (IRE1). The resulting loss of 26 nt from the spliced mRNA causes a frame-shift and an isoform XBP1(S), which is the functionally active transcription factor. The isoform encoded by the unspliced mRNA, XBP1(U), is constitutively expressed, and thought to function as a negative feedback regulator of XBP1(S), which shuts off transcription of target genes during the recovery phase of ER stress. A pseudogene of XBP1 has been identified and localized to chromosome 5. [provided by RefSeq].

Function:
Transcription factor essential for hepatocyte growth, the differentiation of plasma cells, the immunoglobulin secretion, and the unfolded protein response (UPR). Acts during endoplasmic reticulum stress (ER) by activating unfolded protein response (UPR) target genes via direct binding to the UPR element (UPRE). Binds DNA preferably to the CRE-like element 5'-GATGACGTG[TG]N(3)[AT]T-3', and also to some TPA response elements (TRE). Binds to the HLA DR-alpha promoter. Binds to the Tax-responsive element (TRE) of HTLV-I.

Subcellular Location:xy-13071R    Phospho-eNOS (Ser1176)磷酸化一氧化氮合成酶3（內(nèi)皮型）抗體
xy-3552R    Nesfatin-1新的飽食分子蛋白抗體
xy-4051R    Nectin 4脊髓灰質(zhì)炎病毒受體相關(guān)蛋白4抗體
xy-2681R    NKp80細(xì)胞毒性受體NK-p80抗體
xy-2679R    CD112細(xì)胞粘附分子CD112抗體
xy-10233R    Nephrin腎小球細(xì)胞粘附分子受體抗體
xy-10444R    NR5A2/LRH1成纖維細(xì)胞核受體Nr5a2抗體
xy-1550R    NCX1鈉鈣交換蛋白1抗體
xy-2057R    NCX3鈉鈣交換蛋白3抗體
xy-2030R    NMDAR1天冬氨酸受體抗體
xy-2013R    phospho-Nrf2 (Ser40)磷酸化核因子2相關(guān)因子2(Ser40)抗體
xy-10420R    Nemo-like kinaseNemo樣激酶抗體
xy-10421R    Phospho-Nemo-like kinase (Thr298)磷酸化Nemo樣激酶抗體
xy-10402R    phospho-NIFK (Thr238)磷酸化NIFK抗體
xy-10401R    phospho-NIFK (Thr230)磷酸化NIFK抗體
xy-13693R    NCKAP5NCKAP5蛋白抗體
xy-13694R    NOSTRIN一氧化氮合酶轉(zhuǎn)運(yùn)誘導(dǎo)抗體
xy-13656R    NSMAF中性鞘磷脂相關(guān)因子抗體
xy-15592R    NFIL3人白介素3介導(dǎo)核因子抗體
xy-13657R    NSP3SH2結(jié)構(gòu)域蛋白3A抗體
xy-2464R    Neuritin轉(zhuǎn)化神經(jīng)突起蛋白抗體
xy-13765R    NPIP-like protein 1NPIP樣蛋白1抗體
xy-6058R    Nicastrin老年性癡呆蛋白APH2抗體
xy-6060R    NARC1神經(jīng)細(xì)胞凋亡調(diào)節(jié)轉(zhuǎn)化蛋白1抗體（前蛋白轉(zhuǎn)化酶枯草溶菌素9）
xy-12018R    NPFF1 ReceptorG蛋白偶聯(lián)受體147抗體
xy-3513R    Nur77孤兒核受體蛋白Nur77抗體
xy-3313R    Phospho-Nur77(Ser351)磷酸化孤兒核受體蛋白Nur77抗體
xy-0452R    NAIF1 protein核凋亡誘導(dǎo)因子蛋白1
xy-1067R    NMDAR2C谷氨酸受體2C抗體
xy-0175R    TrkB酪氨酸激酶B抗體
xy-1091R    NADPH oxidase 4NADPH氧化酶4抗體
xy-9316R    NDE1核分布基因E同源蛋白1抗體
xy-9317R    NEK9絲氨酸/蘇氨酸蛋白激酶NEK9抗體