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賴氨酸缺陷型蛋白激酶1抗體

英文名稱 WNK1
中文名稱 賴氨酸缺陷型蛋白激酶1抗體
別    名 Erythrocyte 65 kDa protein; HSAN2; HSN2; hWNK1; KDP; KIAA0344; Kinase deficient protein; MGC163339; MGC163341; p65; PRKWNK1; Prostate derived sterile 20 like kinase; Protein kinase lysine deficient 1; Protein kinase lysine-deficient 1; Protein kinase with no lysine 1; PSK; Serine/threonine protein kinase WNK1; Serine/threonine-protein kinase WNK1; With no K; WNK lysine deficient protein kinase 1; WNK1; WNK1_HUMAN.

說 明 書 0.2ml  
研究領(lǐng)域 腫瘤  細(xì)胞生物  免疫學(xué)  信號轉(zhuǎn)導(dǎo)  細(xì)胞凋亡  轉(zhuǎn)錄調(diào)節(jié)因子  通道蛋白  轉(zhuǎn)運蛋白  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 251kDa
細(xì)胞定位 細(xì)胞漿 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human WNK1
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
WNK1 controls sodium and chloride ion transport by inhibiting the activity of WNK4, potentially by either phosphorylating the kinase or via an interaction between WNK4 and the autoinhibitory domain of WNK1. WNK4 regulates the activity of the thiazide sensitive Na/Cl cotransporter, SLC12A3, by phosphorylation. WNK1 may also play a role in actin cytoskeletal reorganization.


Function:
Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SCNN1A, SCNN1B, SCNN1D and SGK1. Controls sodium and chloride ion transport by inhibiting the activity of WNK4, by either phosphorylating the kinase or via an interaction between WNK4 and the autoinhibitory domain of WNK1. WNK4 regulates the activity of the thiazide-sensitive Na-Cl cotransporter, SLC12A3, by phosphorylation. WNK1 may also play a role in actin cytoskeletal reorganization. Phosphorylates NEDD4L (By similarity). xy-5111R    OPRS1衰老相關(guān)Sigma受體蛋白抗體
xy-2128R    OST-beta有機溶質(zhì)轉(zhuǎn)運蛋白OSTβ抗體
xy-2173R    Noelin嗅球蛋白1抗體
xy-11791R    OA1眼部白化病相關(guān)蛋白OA1/蛋白偶聯(lián)受體143抗體
xy-6295R    Oncostatin M癌基因蛋白抑瘤素M抗體
xy-6298R    OVCA2卵巢癌相關(guān)基因2蛋白抗體
xy-9541R    Orai2跨膜蛋白Orai2抗體
xy-11060R    OTOA耳聾、常染色體隱性遺傳22抗體
xy-9802R    C1orf801號染色體開放閱讀框80抗體
xy-0687R    OAS1寡腺苷酸合成酶-1
xy-8359R    KLHDC9KLHDC9蛋白抗體
xy-11922R    OLIG3少突膠質(zhì)細(xì)胞轉(zhuǎn)錄因子3抗體
xy-11920R    OTP螺旋轉(zhuǎn)錄因子OTP抗體
xy-2086R    ompF小腸結(jié)腸炎耶爾森氏菌膜通道蛋白抗體
xy-9368R    OCEL1緊密連接蛋白/小分子膠原蛋白OCEL1抗體
xy-12143R    SHANK3富含脯氨酸突觸相關(guān)蛋白SHANK3抗體
xy-12154R    Oncomodulin癌調(diào)蛋白/癌鈣蛋白抗體
xy-1200R    Omgp少突細(xì)胞髓磷脂糖蛋白抗體
xy-1081R    OPCML阿片樣物質(zhì)結(jié)合蛋白/細(xì)胞粘附分子樣蛋白抗體
xy-13615R    ODF4外致密纖維精子尾部蛋白4抗體
xy-15588R    OAS22'-5'-寡腺苷酸合成酶2抗體
xy-3623R    mu Opioid receptorμ-型阿片受體抗體
xy-3712R    Phospho-delta Opioid Receptor (Ser363)磷酸化D型阿片受體抗體
xy-5089R    OXCT1含氧酸輔酶A轉(zhuǎn)移酶1抗體
xy-5095R    Oncostatin M抑瘤素M抗體
xy-5096R    OSMR抑瘤素M受體抗體
xy-12274R    OVOL2鋅指蛋白339抗體
xy-4248R    ORP150氧氣調(diào)節(jié)蛋白150抗體
xy-2927R    OXSR1氧化應(yīng)激反應(yīng)蛋白1抗體
xy-11919R    ODZ1固生蛋白M抗體
xy-8038R    OGFOD1末端多聚腺苷酸1蛋白抗體
xy-11061R    Optimedin嗅球蛋白3抗體
xy-11596R    OTX1轉(zhuǎn)錄因子OTX1抗體
xy-11597R    OTX2轉(zhuǎn)錄因子OTX2抗體