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磷酸化WEE1蛋白抗體

英文名稱 Phospho-Wee1(Ser123)
中文名稱 磷酸化WEE1蛋白抗體
別    名 DKFZp686I18166; EC 2.7.10.2; FLJ16446; Wee 1; Wee1 homolog; WEE1 homolog S. pombe; Wee1 like protein kinase; Wee1 tyrosine kinase; Wee1+ homolog; Wee1+ S. pombe homolog; WEE1A; Wee1A kinase; WEE1hu; WEE1 tyrosine kinase isoform 1; MGC105683; WEE1_HUMAN.

說 明 書 0.1ml  
產(chǎn)品類型 磷酸化抗體 
研究領域 腫瘤  免疫學  信號轉(zhuǎn)導  干細胞  細胞凋亡  轉(zhuǎn)錄調(diào)節(jié)因子  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, 
產(chǎn)品應用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 72kDa
細胞定位 細胞核 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated Synthesised phosphopeptide derived from human Wee1 around the phosphorylation site of Ser123 [SS(p-S)PV]
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
This gene encodes a nuclear protein, which is a tyrosine kinase belonging to the Ser/Thr family of protein kinases. This protein catalyzes the inhibitory tyrosine phosphorylation of CDC2/cyclin B kinase, and appears to coordinate the transition between DNA replication and mitosis by protecting the nucleus from cytoplasmically activated CDC2 kinase.

Function:
Acts as a negative regulator of entry into mitosis (G2 to M transition) by protecting the nucleus from cytoplasmically activated cyclin B1-complexed CDK1 before the onset of mitosis by mediating phosphorylation of CDK1 on 'Tyr-15'. Specifically phosphorylates and inactivates cyclin B1-complexed CDK1 reaching a maximum during G2 phase and a minimum as cells enter M phase. Phosphorylation of cyclin B1-CDK1 occurs exclusively on 'Tyr-15' and phosphorylation of monomeric CDK1 does not occur. Its activity increases during S and G2 phases and decreases at M phase when it is hyperphosphorylated. A correlated decrease in protein level occurs at M/G1 phase, probably due to its degradation.

Subcellular Location:
Nucleus.xy-9900R    PAFAH1B2血小板衍化生長因子β抗體
xy-9901R    PAFAHG血小板衍化生長因子γ抗體
xy-9902R    p47血小板47蛋白抗體
xy-9916R    PAPP A2妊娠相關血漿蛋白A2抗體
xy-9917R    PGCP血漿谷氨酸羧肽酶抗體
xy-3704R    phospho-P53(Ser315)磷酸化腫瘤抑制基因P53抗體
xy-0891R    Pokemon蒙蛋白抗體
xy-0588R    PALB2乳腺癌易感基因相關蛋白2
xy-1299R    Parvalbumin細小清蛋白抗體
xy-9524R    PIGA紅細胞磷脂酰肌醇聚糖A抗體
xy-11124R    PCDHA11原鈣粘蛋白11抗體
xy-2301R    CD162P選擇素糖蛋白配體1抗體
xy-0875R    PKN2蛋白激酶N2抗體
xy-1209R    GRK2G蛋白偶合受體激酶2抗體
xy-11291R    PHC2早期發(fā)育調(diào)控蛋白2抗體
xy-4702R    Phospholipase C beta 3磷酯酶Cβ3
xy-10073R    PDGF-A血小板源性生長因子A抗體
xy-4967R    PAPOLB睪丸特異性核苷酸果糖β抗體
xy-9942R    C11orf7311號染色體開放閱讀框73抗體
xy-11306R    PCYT1A 磷酸乙醇胺轉(zhuǎn)移酶A抗體
xy-11307R    Prostaglandin I2 Receptor前列環(huán)素受體抗體
xy-11085R    PCDH7原鈣粘蛋白7抗體
xy-8584R    PXMP1過氧化物酶膜蛋白1抗體
xy-11063R    Plakophilin 2橋粒斑菲素蛋白2抗體
xy-11062R    PSCDBP胞粘蛋白結(jié)合調(diào)節(jié)蛋白抗體
xy-11574R    PCTAIRE2絲氨酸/蘇氨酸蛋白激酶PCTK2抗體
xy-11575R    PDE7A磷酸二酯酶7抗體
xy-11576R    PDE7B磷酸二酯酶7B抗體
xy-11577R    PHOX2A先天性眼外肌纖維化相關蛋白FEOM2抗體
xy-11578R    PHOX2B神經(jīng)母細胞瘤蛋白PHOX2B抗體
xy-11611R    p35細胞周期蛋白依賴性激酶5激活因子1抗體