WW結(jié)構(gòu)域E3泛素連接酶1抗體 返回列表頁

WW結(jié)構(gòu)域E3泛素連接酶1抗體

英文名稱 WWP1
中文名稱 WW結(jié)構(gòu)域E3泛素連接酶1抗體
別    名 AIP 5; AIP5; Atropin-1-interacting protein 5; hSDRP1; nedd4 like; NEDD4-like E3 ubiquitin-protein ligase WWP1; Tiul1; WW domain containing E3 ubiquitin protein ligase 1; WW domain-containing protein 1; WWP 1; WWP1_HUMAN.

說 明 書 0.2ml  
研究領(lǐng)域 腫瘤  細胞生物  信號轉(zhuǎn)導  腫瘤細胞生物標志物  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Sheep, 
產(chǎn)品應用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 105kDa
細胞定位 細胞核 細胞漿 細胞膜 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human WWP1
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
WWP1 is an E3 ubiquitin ligase and belongs to a family of NEDD4-like proteins. WWP1 contains 4 tandem WW domains and a HECT (homologous to the E6-associated protein carboxyl terminus) domain. WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. The HECT domain of WWP1 has been implicated in regulating the localization and stability of p53 – inhibition of WWP1 results in a decrease in p53 expression, whilst WWP1 mediated stabilization of p53 appears to be associated with an accumulation of cytoplasmic p53. WWP1 also negatively regulates the TGF beta tumor suppressor pathway by inactivating its molecular components (SMAD2, SMAD4 and TGFbetaR1). WWP1 has been implicated in both breast and prostate cancers.

Function:
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Ubiquitinates ERBB4 isoforms JM-A CYT-1 and JM-B CYT-1, KLF2, KLF5 and TP63 and promotes their proteasomal degradation. Ubiquitinates RNF11 without targeting it for degradation. Ubiquitinates and promotes degradation of TGFBR1; the ubiquitination is enhanced by SMAD7. Ubiquitinates SMAD6 and SMAD7. Ubiquitinates and promotes degradation of SMAD2 in response to TGF-beta signaling, which requires interaction with TGIF.xy-0490R    PPP4C磷酸酯酶-2Ac抗體
xy-0636R    Phospho-P38 MAPK (Thr180 + Tyr182)磷酸化-絲裂原活化蛋白激酶p38抗體（P-p38 MAPK）
xy-0250R    PPAR delta + betaD型-過氧化酶活化增生受體抗體
xy-0530R    PPAR gamma過氧化酶活化增生受體γ抗體（PPARγ）
xy-0111R    progesterone receptor孕激素受體抗體
xy-0532R    PHD3脯氨酸羥化酶抗體
xy-0024R    presenilin 1早老素蛋白-1抗體
xy-0025M    presenilin 1早老素蛋白-1抗體
xy-0024M    presenilin 1早老素蛋白-1抗體
xy-0669R    PSCA前列腺干細胞抗原抗體
xy-0179R    PSD95突觸后密度蛋白95抗體
xy-0561R    P-selectin/CD62pP選擇素抗體
xy-0748R    PTEN一種腫瘤抑制基因抗體（N端）
xy-1115R    AMPK alpha-1腺苷單磷酸活化蛋白激酶α1/AMPK α 1抗體
xy-0040R    protein C維生素K依賴的蛋白C重鏈抗體
xy-2692R    Plexin A1神經(jīng)叢蛋白A1抗體
xy-3517R    PAK4p21激活激酶4抗體
xy-3314R    Phospho-PAK4(Ser474) + PAK5(Ser602) + PAK6(Ser560)磷酸化p21激活激酶4/5/6抗體
xy-3315R    Phospho-PAK1(Ser199 + Ser204) + PAK2 (Ser192 + Ser197)磷酸化p21激活激酶1/2抗體
xy-3316R    Phospho-PAK1 + PAK2 + PAK3 (T423 + T402 + T421)磷酸化p21激活激酶1/2抗體
xy-3317R    Phospho-PAK2 (Ser20)磷酸化p21激活激酶2抗體
xy-3532R    PLCG 2磷酯酶Cγ2抗體
xy-3318R    Phospho-PDGFRA(Tyr1018)磷酸化血小板源性生長因子受體-α抗體
xy-3319R    Phospho-PDGFRA(Tyr754)磷酸化血小板源性生長因子受體-α抗體
xy-1346R    P73 proteinP73腫瘤抑制基因抗體
xy-4958R    PCGF1表觀抑制因子Polycomb家族成員PCGFl蛋白抗體
xy-12070R    P2Y10G蛋白偶聯(lián)嘌呤受體p2y10抗體
xy-0190R    PACAP-27/38腺苷酸環(huán)化酶激活肽-27/38抗體
xy-0534R    p19ARFp19ARF抑癌基因抗體
xy-0741R    CDKN1Ap21蛋白抗體