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端粒酶卡哈爾體蛋白抗體

英文名稱 TCAB1
中文名稱 端粒酶卡哈爾體蛋白抗體
別    名 FLJ10385; TCAB1; omerase Cajal Body protein 1; WD repeat containing protein 79; WRAP53; WDR79/TCAB1; WAP53_HUMAN.

說 明 書 0.2ml  
研究領(lǐng)域 腫瘤  細(xì)胞生物  免疫學(xué)  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, Horse, Rabbit, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 60kDa
細(xì)胞定位 細(xì)胞核 細(xì)胞漿 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human WDR79/TCAB1（304-347aa）
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
WDR79 contains six WD (tryptophan-aspartate) repeat domains found in a number of proteins that function as adaptor molecules in signal transduction and cytoskeletal organization. The WD repeat is defined by four or more repeating units of a conserved core of approximay 40 amino acids ending with tryptophan-aspartic acid (WD). WD repeats may serve as sites of protein-protein interaction for adaptor proteins and facilitate multiprotein complex formation. The function of the WDR79 protein has not been characterized, however significant and consistent single nucleotide polymorphisms in the WDR79 gene have been found to be associated with ER negative breast cancer.

Function:
Essential component of the omerase holoenzyme complex, a ribonucleoprotein complex essential for the replication of chromosome termini that elongates omeres in most eukaryotes. In the omerase holoenzyme complex, it controls omerase localization to Cajal body. Required for delivery of TERC to omeres during S phase and for omerase activity. Binds small Cajal body RNAs (scaRNAs). The mRNA encoding this protein plays a critical role in the regulation of p53 expression at the post-transcriptional level; it is involved both in maintaining basal p53 mRNA levels and in p53 induction upon DNA damage.

Subunit:
Component of the omerase holoenzyme complex at least composed of TERT, DKC1, WRAP53/TCAB1, 0, NHP2, GAR1, TEP1, EST1A, POT1 and a omerase RNA template component (TERC).xy-5579R    phospho-PIK3C3(Ser282)磷酸化磷脂酰肌醇激酶3催化亞單位3抗體
xy-2970R    PHGDH磷酸甘油酸脫氫酶抗體
xy-5569R    phospho-PRL (Ser163)磷酸化泌乳素抗體
xy-2593R    pro-caspase-3半胱天冬酶-3酶原抗體
xy-12562R    Phospho1細(xì)胞質(zhì)磷酸酶1抗體
xy-12313R    PHEX維生素D低磷性佝僂病蛋白
xy-12324R    PTCHD2多通道膜蛋白PTCHD2抗體
xy-12325R    PTCHD3修補(bǔ)相關(guān)蛋白PTCHD3抗體
xy-4148R    PKMYT1髓鞘轉(zhuǎn)錄因子1激酶抗體
xy-5531R    phospho-PKMYT1(Thr495)磷酸化髓鞘轉(zhuǎn)錄因子1激酶抗體
xy-5532R    Phospho-PDGFRA(Tyr988)磷酸化血小板源性生長(zhǎng)因子受體α
xy-5533R    Phospho-PDGFRA(Tyr572)+PDGFRB(Tyr579) 磷酸化血小板源性生長(zhǎng)因子受體α
xy-5534R    Phospho-PDGFRA(Tyr762)磷酸化血小板源性生長(zhǎng)因子受體α
xy-2282R    PPO兒茶酚氧化酶PPO抗體
xy-2329R    PKC epsilon蛋白激酶C抗體
xy-3789R    Perilipin A脂滴包被蛋白Perilipin-A抗體
xy-3833R    PABP多聚腺苷酸結(jié)合蛋白抗體
xy-9031R    PAS1C1核纖層蛋白A相關(guān)結(jié)構(gòu)蛋白1抗體
xy-9034R    PCID2PCID2蛋白抗體
xy-9029R    PAPSS1腺苷酸硫酸激酶1抗體
xy-9030R    PAPSS2腺苷酸硫酸激酶2抗體
xy-9510R    PAR3蛋白酶激活受體3抗體
xy-9032R    PBLDMAWD結(jié)合蛋白抗體
xy-9033R    PCID1PCID1蛋白抗體
xy-9041R    PDZD6PDZ結(jié)構(gòu)域PDZK6蛋白抗體
xy-9035R    PDXK吡哆醛激酶抗體
xy-9036R    PDZK1PDZ結(jié)構(gòu)域PDZK1蛋白抗體
xy-9037R    PDZK3前列腺癌激活蛋白抗體
xy-9038R    PDZK4PDZ結(jié)構(gòu)域PDZK4蛋白抗體
xy-9042R    PDZD7PDZ結(jié)構(gòu)域PDZK7蛋白抗體
xy-9043R    PDZD8PDZ結(jié)構(gòu)域PDZK8蛋白抗體
xy-5613R    phospho-PTK9 (Tyr321)磷酸化蛋白酪氨酸激酶9抗體
xy-3865R    PRDX5+PRDX6過氧化還原酶5/6抗體
xy-3875R    PRDX1過氧化還原酶1抗體