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液泡蛋白分選蛋白4B抗體

英文名稱 VPS4B
中文名稱 液泡蛋白分選蛋白4B抗體
別    名 8030489C12Rik; Cell migration inducing 1; Cell migration-inducing gene 1 protein; MGC116271; MIG1; Protein SKD1; Skd1; SKD1B; Suppressor of K(+) transport growth defect 1; Suppressor of K+ transport defect 1; Vacuolar protein sorting 4 homolog B (S. cerevisiae); Vacuolar protein sorting 4 homolog B; Vacuolar protein sorting 4b; Vacuolar protein sorting-associated protein 4B; Vacuolar protein sorting-associating protein 4B; VPS4 2; VPS42; Vps4b; VPS4B_HUMAN.

說 明 書 0.2ml  
研究領(lǐng)域 細(xì)胞生物  信號(hào)轉(zhuǎn)導(dǎo)  轉(zhuǎn)運(yùn)蛋白  跨膜蛋白  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, Pig, Cow, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 49kDa
細(xì)胞定位 細(xì)胞膜 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human VPS4B
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
The protein encoded by this gene is a member of the AAA protein family (ATPases associated with diverse cellular activities), and is the homolog of the yeast Vps4 protein. In humans, two paralogs of the yeast protein have been identified. The former share a high degree of aa sequence similarity with each other, and also with yeast Vps4 and mouse Skd1 proteins. Mouse Skd1 (suppressor of K+ transport defect 1) has been shown to be a yeast Vps4 ortholog. Functional studies indicate that both human paralogs associate with the endosomal compartments, and are involved in intracellular protein trafficking, similar to Vps4 protein in yeast. The gene encoding this paralog has been mapped to chromosome 18; the gene for the other resides on chromosome 16. [provided by RefSeq, Jul 2008]

Function:
Involved in late steps of the endosomal multivesicular bodies (MVB) pathway. Recognizes membrane-associated ESCRT-III assemblies and catalyzes their disassembly, possibly in combination with membrane fission. Redistributes the ESCRT-III components to the cytoplasm for further rounds of MVB sorting. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. In conjunction with the ESCRT machinery also appears to function in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and enveloped virus budding (HIV-1 and other lentiviruses).

Subcellular Location:
Prevacuolar compartment membrane. Late endosome membrane. Membrane-associated in the prevacuolar endosomal compartment. Localized in HIV-1 particles purified from acuy infected cells.

Tissue Specificity:
Ubiquitously expressed.

Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR.xy-2283R    EMC1腺樣癌特異性相關(guān)抗原EMC1抗體
xy-3966R    PPM2C蛋白磷酸酶2C抗體
xy-9393R    CAF1p55染色質(zhì)組裝因子1P55抗體
xy-8458R    PTRFRNA聚合酶1和轉(zhuǎn)錄釋放因子抗體
xy-8866R    PISD磷脂酰絲氨酸脫羧酶PISD抗體
xy-3742R    PNPLA1含patatin樣磷脂酶1抗體
xy-3698R    PML早幼粒細(xì)胞白血病蛋白抗體
xy-2265R    Peptide YY/PYY酪酪肽抗體
xy-9289R    PACRG麻瘋病和帕金森氏病共同調(diào)節(jié)蛋白抗體
xy-9290R    RNF131環(huán)指蛋白131抗體
xy-3807R    Phospholipase A2 activator protein磷脂酶A2激活蛋白抗體
xy-3809R    thymidine phosphorylase胸苷磷酸化酶抗體
xy-3817R    Piwil2piwi樣2蛋白抗體
xy-3815R    presenilin 2早老素蛋白-2抗體
xy-8176R    PHF8組蛋白賴氨酸去甲基化酶PHF8抗體
xy-9363R    TRAP2腫瘤壞死因子受體相關(guān)蛋白2抗體
xy-9366R    PSMD7蛋白酶調(diào)解因子7抗體
xy-2215R    phosphos-PCNA (Tyr211)磷酸化增殖細(xì)胞核抗原抗體
xy-3027R    phospho-AMPK beta 1 (Ser182)磷酸化腺苷單磷酸活化蛋白激酶β1抗體
xy-4033R    PDHB丙酮酸脫氫酶E1β亞單位抗體
xy-4032R    PHKB磷酸化酶β抗體
xy-4030R    Pancreatic Amylase胰淀粉酶抗體
xy-4034R    PDHA1丙酮酸脫氫酶α1抗體
xy-4036R    phospho-PDHA1(Ser293)磷酸化丙酮酸脫氫酶α1抗體
xy-2739R    PDPK13磷酸肌醇依賴性蛋白激酶1抗體
xy-3017R    Phospho-PDPK1(Tyr373 + Tyr376)磷酸化3磷酸肌醇依賴性蛋白激酶1抗體
xy-2740R    p53BP1p53結(jié)合蛋白1抗體
xy-3726R    phospho-PKC delta (Tyr52)磷酸化蛋白激酶C亞性D型抗體
xy-3727R    phospho-PKC delta (Thr505/507)磷酸化蛋白激酶C亞性D型抗體
xy-10399R    PKC zeta蛋白激酶C zeta 抗體
xy-7340R    PRG2嗜酸性粒細(xì)胞顆粒關(guān)鍵堿性蛋白抗體
xy-1664R    Proinsulin胰島素原抗體