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信號通路Wnt1抗體

英文名稱 Wnt1
中文名稱 信號通路Wnt1抗體
別    名 wingless-type MMTV integration site family, member 1; INT 1; INT1; Murine mammary tumor virus integration site 1 ; Oncogene INT1; Proto oncogene protein Wnt 1; Wnt 1; Wnt1 proto oncogene protein precursor; WNT1_HUMAN.

說 明 書 0.1ml  0.2ml  
研究領域 腫瘤  免疫學  神經生物學  信號轉導  轉錄調節(jié)因子  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human, Mouse, Rat, Chicken, Cow, Horse, 
產品應用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 39kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human Wnt1
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產品介紹 background:
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is very conserved in evolution, and the protein encoded by this gene is known to be 98% identical to the mouse Wnt1 protein at the amino acid level. The studies in mouse indicate that the Wnt1 protein functions in the induction of the mesencephalon and cerebellum. This gene was originally considered as a candidate gene for Joubert syndrome, an autosomal recessive disorder with cerebellar hypoplasia as a leading feature. However, further studies suggested that the gene mutations might not have a significant role in Joubert syndrome. This gene is clustered with another family member, WNT10B, in the chromosome 12q13 region.

Function:
Ligand for members of the frizzled family of seven transmembrane receptors. In some developmental processes, is also a ligand for the coreceptor RYK, thus triggering Wnt signaling. Probable developmental protein. May be a signaling molecule important in CNS development. Is likely to signal over only few cell diameters.xy-13280R    RASA1Rho GTP酶激活蛋白1/血管畸形骨肥大綜合征相關蛋白抗體
xy-13281R    phospho-RASA1 (Tyr460)磷酸化Rho GTP酶激活蛋白1/血管畸形骨肥大綜合征相關蛋白抗體
xy-9166R    RNF87環(huán)指蛋白87
xy-5330R    Phospho-RhoA(Ser188)磷酸化RhoA蛋白抗體
xy-9180R    RSL1D1細胞衰老抑制基因蛋白抗體
xy-9181R    Repetin中間絲相關蛋白抗體
xy-9167R    RNF86環(huán)指蛋白86
xy-9168R    RING2環(huán)指蛋白2抗體
xy-9171R    RNF44環(huán)指蛋白44抗體
xy-9170R    RNF40環(huán)指蛋白40抗體
xy-9173R    RNF8環(huán)指蛋白8抗體
xy-6088R    RASAL1RAS蛋白樣激活劑1抗體
xy-2939R    RASSF2Ras相關結構域蛋白質2抗體
xy-6093R    RIL抑癌基因PDLIM4抗體
xy-6094R    RIN1RAS抑制蛋白1抗體
xy-6101R    RUNX1T1周期素D相關蛋白抗體
xy-6095R    RND3Rho家族GTP酶3抗體
xy-6096R    RNF139環(huán)指蛋白139抗體
xy-6098R    Rho GTPase activating protein 29Rho GTP酶激活蛋白29抗體
xy-6097R    RSRC2食道癌抑制生長蛋白抗體
xy-6089R    RASSF8RAS家族關聯(lián)結構域蛋白8抗體
xy-4282R    Ran雄激素受體相關蛋白24抗體
xy-6501R    Rab25癌基因RAS相關蛋白Rab25抗體
xy-6219R    RXR beta核受體RXRβ抗體
xy-6218R    RAR gamma維甲酸受體γ抗體
xy-4630R    phospho-ROCK1(Thr455+Ser456)磷酸化Rho相關蛋白激酶1抗體
xy-6130R    RbAp48視網(wǎng)膜母細胞瘤結合蛋白P48抗體
xy-11358R    RIMBP2神經元突觸膜結合蛋白2抗體
xy-11359R    RIMS3神經元突觸膜胞外分泌調節(jié)蛋白3抗體
xy-11360R    RIMS4神經元突觸膜胞外分泌調節(jié)蛋白4抗體
xy-11369R    SynGAP認知缺陷突觸相關蛋白SynGAP抗體