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磷酸化粘著斑蛋白抗體

英文名稱 phospho-Vinculin (Tyr822)
中文名稱 磷酸化粘著斑蛋白抗體
別    名 Vinculin (phospho Y822); p-Vinculin (phospho Y822); CMD1W; CMH15; Epididymis luminal protein 114; HEL114; Metavinculin; MV; MVCL; OTTHUMP00000019861; OTTHUMP00000019862; VCL; VINC; VINC_HUMAN; Vinculin.

說 明 書 0.1ml  
產(chǎn)品類型 磷酸化抗體 
研究領(lǐng)域 心血管  細(xì)胞生物  信號(hào)轉(zhuǎn)導(dǎo)  細(xì)胞骨架  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, Chicken, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 124kDa
細(xì)胞定位 細(xì)胞漿 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthesised phosphopeptide derived from human Vinculin around the phosphorylation site of Tyr822
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
Vinculin is a cytoskeletal protein associated with cell-cell and cell-matrix junctions, where it is thought to function as one of several interacting proteins involved in anchoring F-actin to the membrane. Defects in VCL are the cause of cardiomyopathy dilated type 1W. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008]

Function:
Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion.

Subcellular Location:
Cytoplasm > cytoskeleton. Cell junction > adherens junction. Cell membrane. Cytoplasmic face of adhesion plaques. Recruitment to cell-cell junctions occurs in a myosin II-dependent manner. Interaction with CTNNB1 is necessary for its localization to the cell-cell junctions.xy-1322R    gamma tubulin (Centrosome Marker )微管蛋白γ/Tubulin γ抗體
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xy-0885R    phospho-Tau protein(Thr498)磷酸化微管相關(guān)蛋白抗體
xy-9113R    TAS1R3G蛋白偶聯(lián)受體TAS1R3抗體
xy-0233R    TERT端粒酶反轉(zhuǎn)錄酶抗體
xy-1203R    TOP2ADNA拓普西異構(gòu)酶Ⅱ抗體
xy-2107R    T7 tagT7 tag標(biāo)簽抗體
xym-0387M    TNF-alpha(1F6)腫瘤壞死因子-α單克隆抗體
xy-0078R    TNF alpha腫瘤壞死因子-α/TNFα抗體
xy-0329R    TRA16睪丸激素孤兒受體相關(guān)蛋白抗體
xy-0417R    TIMP-3金屬蛋白酶組織抑制因子-3抗體
xy-1019R    TLR2Toll樣受體2抗體
xy-1021R    TLR4Toll樣受體4抗體
xy-0525R    Thrombomodulin血栓調(diào)節(jié)蛋白抗體
xy-0975R    SP1轉(zhuǎn)錄生長(zhǎng)因子SP1抗體
xy-2101R    TEM1內(nèi)涎蛋白/內(nèi)皮唾液酸蛋白抗體
xy-6702R    TRPC3色氨酸相關(guān)蛋白3抗體
xy-6400R    TFDP3轉(zhuǎn)錄因子DP3抗體（肝癌相關(guān)抗原661）
xy-6696R    TRPV2辣椒素受體樣蛋白1抗體
xy-6690R    Transglutaminase谷氨酰胺轉(zhuǎn)胺酶1抗體
xy-6699R    TIAM1T淋巴瘤侵襲轉(zhuǎn)移誘導(dǎo)蛋白1抗體
xy-7049R    TNFAIP2腫瘤壞死因子誘導(dǎo)蛋白2(TNFα-IP 2)抗體
xy-11616R    TAS2R16味覺受體蛋白家族2亞基16抗體
xy-4256R    Thioredoxin 2線粒體硫氧還蛋白2抗體
xy-2929R    TNFRSF5腫瘤壞死因子受體超家族成員5抗體
xy-5845R    TAG1瞬時(shí)表達(dá)軸索糖蛋白1抗體
xy-6662R    TYK2非受體酪氨酸蛋白激酶2抗體
xy-5783R    TNFAIP5腫瘤壞死因子α誘導(dǎo)蛋白5
xy-5780R    TNFC腫瘤壞死因子C
xy-5778R    TGFB4轉(zhuǎn)化生長(zhǎng)因子β4抗體
xy-4135R    TAB1轉(zhuǎn)化生長(zhǎng)因子β活化激酶結(jié)合蛋白1抗體
xy-3897R    TXNIP硫氧還蛋白結(jié)合蛋白2抗體
xy-6262R    TRIB2MAPK調(diào)控蛋白TRB2抗體
xy-2374R    TAP2ATP結(jié)合轉(zhuǎn)運(yùn)因子2抗體
xy-5093R    TECK胸腺表達(dá)趨化因子抗體
xy-2368R    phospho-Tau protein(Thr231)磷酸化微管相關(guān)蛋白抗體