轉(zhuǎn)錄輔助因子退變樣蛋白4抗體 返回列表頁

轉(zhuǎn)錄輔助因子退變樣蛋白4抗體

英文名稱 VGLL4
中文名稱 轉(zhuǎn)錄輔助因子退變樣蛋白4抗體
別    名 Transcription cofactor vestigial like protein 4; Vestigial like protein 4; VGL 4; VGLL4; VGLL4_HUMAN.

說 明 書 0.1ml  0.2ml  
研究領(lǐng)域 細胞生物  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蠟切片需做抗原修復） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 31kDa
細胞定位 細胞核 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human VGLL4
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 癈 for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20癈. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 癈.

PubMed PubMed
產(chǎn)品介紹 background:
The transcriptional enhancer factor-1 (TEF-1) family of transcription factors regulate tissue-specific gene expression in muscle and placenta. The mechanism whereby TEF-1 confers tissue specificity depends largely on the interaction of TEF-1 with tissue-specific cofactors. Transcription cofactor Vgl-4 (vestigial-like protein 4) is a 290 amino acid nuclear protein that interacts with TEF-1 and MEF-2. Vgl-4 is the only member of the vestigial-like family that is expressed in heart. Overexpression of Vgl-4 in cardiac myocytes interferes with basal expression and ?-adrenergic receptor-dependent activation of a TEF-1 dependent skeletal ?actin promoter. This suggests that Vgl-4 counteracts ?-adrenergic activation of gene expression in cardiomyocytes. There are two isoforms of Vgl-4 that are produced as a result of alternative splicing events. 

Function:
May act as a specific coactivator for the mammalian TEFs (By similarity). 

Subunit:
Interacts with TEFs (By similarity). Interacts with IRF2BP2.

Subcellular Location:
Nuclear

Similarity:
Belongs to the vestigial family. 

Gene ID:
9686

Database links:

Entrez Gene: 9686 Human

Entrez Gene: 232334 Mouse

Entrez Gene: 297523 Rat

SwissProt: Q14135 Human

SwissProt: Q80V24 Mouse

Unigene: 23131 Rat

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