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氫離子轉(zhuǎn)運(yùn)ATP合成酶A1抗體

英文名稱(chēng) V-ATPase A1
中文名稱(chēng) 氫離子轉(zhuǎn)運(yùn)ATP合成酶A1抗體
別    名 V ATPase; V ATPase A; V ATPase A1; Vacuolar proton ATPase a1; V-type proton ATPase 95 kDa subunit a isoform 1; V-ATPase 95 kDa isoform a1; AltName: Full=Vacuolar proton pump subunit a1; Vacuolar proton translocating ATPase 95 kDa subunit a isoform 1; VPP1_HUMAN.

說(shuō) 明 書(shū) 0.2ml  
研究領(lǐng)域 細(xì)胞生物  激酶和磷酸酶  通道蛋白  細(xì)胞膜受體  轉(zhuǎn)運(yùn)蛋白  
抗體來(lái)源 Rabbit
克隆類(lèi)型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 96kDa
細(xì)胞定位 細(xì)胞漿 細(xì)胞膜 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human V-ATPase A1 (1-100aa)
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
The subunit of the vacuolar proton pump is a V-ATPase that has two different isoforms. The type I isoform contains an 18-base pair insert and is expressed in brain, whereas the truncated type II isoform is more widely expressed, including lung, kidney and spleen. The subunit of the vacuolar proton pump is located in clathrin-coated vesicles and is also found in osteoclasts. It consists of two fundamental domains, a hydrophilic amino-terminus, which has greater than 30% charged residues, and a hydrophobic carboxy terminus, which contains at least six transmembrane regions. The proton pump functions in coupling ATP hydrolysis by the cytoplasmic subunits to proton translocation by the intramembranous components of the pump. The inactivation of the osteoclast-specific vacuolar proton ATPase subunit is responsible for the lack of the enzyme in the apical membranes of osteoclast cells in osteosclerotic mutant mice, thus preventing the resorption function of these cells and leading to the osteopetrotic phenotype. The subunit, which co-localizes with the late endosomal marker Rab7 on vacuolar membranes, is essential for vacuole formation by selective swelling of late endosomes.xy-12231R    ZNF619鋅指蛋白619抗體
xy-12233R    ZNF131鋅指蛋白131抗體
xy-12234R    ZNF131鋅指蛋白131抗體
xy-12236R    ZNF449鋅指蛋白449抗體
xy-12235R    ZNF346鋅指蛋白346抗體
xy-12237R    ZNF532鋅指蛋白532抗體
xy-12238R    ZNF516鋅指蛋白516抗體
xy-12239R    ZNF750鋅指蛋白750抗體
xy-12476R    ANKZF1鋅指蛋白744抗體
xy-15382R    ZNT8鋅轉(zhuǎn)運(yùn)體8蛋白抗體
xy-12224R    ZNF852鋅指蛋白852抗體
xy-13587R    ZNF503鋅指蛋白503抗體
xy-13589R    ZNF672鋅指蛋白672抗體
xy-13603R    ZMYM2鋅指蛋白198抗體
xy-13604R    ZNF323鋅指蛋白323抗體
xy-13605R    ZNF206鋅指蛋白206抗體
xy-13755R    Zonula occludens protein 3緊密粘連蛋白ZO-3抗體
xy-13556R    ZBT10鋅指蛋白ZBT10抗體
xy-13552R    ZBED2鋅指蛋白BED抗體
xy-2510R    ZNF217鋅指蛋白217抗體
xy-13588R    ZNF575鋅指蛋白575抗體
xy-12306R    ZFX鋅指蛋白X染色體蛋白抗體
xy-13546R    ZAK宮頸癌抑制蛋白4抗體
xy-13547R    ZAN透明帶黏附蛋白ZAN抗體
xy-7707R    ZBTB2鋅指蛋白437抗體
xy-7708R    ZNF415鋅指蛋白415抗體
xy-13568R    ZBTB25鋅指蛋白46抗體
xy-13558R    ZNF93鋅指蛋白93抗體
xy-12228R    ZNF568鋅指蛋白568抗體