血管假性血友病因子/血管性血友病因子抗體 返回列表頁

血管假性血友病因子/血管性血友病因子抗體

英文名稱 Von Willebrand Factor
中文名稱 血管假性血友病因子/血管性血友病因子抗體
別    名 Von Willebrand Factor; Coagulation factor VIII; F8VWF; Factor VIII related antigen; von Willebrand antigen 2; Von Willebrand antigen II; Von Willebrand disease; VWD; VWF; Coagulation factor VIII; Coagulation factor VIII VWF; F8VWF; VWF_HUMAN.

說 明 書 0.1ml  0.2ml  
研究領(lǐng)域 腫瘤  心血管  細胞生物  發(fā)育生物學(xué)  生長因子和激素  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 309kDa
細胞定位 細胞外基質(zhì) 分泌型蛋白 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human VWF/Von Willebrand Factor
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
Von Willebrand Factor (VWF) was previously known as Factor VIII related antigen. VWF is synthesized exclusively by endothelial cells and megakaryocytes, and stored in the intracellular granules or constitutively secreted into plasma. This glycoprotein functions as both an antihemophilic factor carrier and a plaet vessel wall mediator in the blood coagulation system. Important in the maintenance of homeostasis, it participates in plaet vessel wall interactions by forming a noncovalent complex with coagulation factor VIII at the site of vascular injury. The Von Willebrand factor has functional binding domains to plaet glycoprotein Ib, glycoprotein IIb/IIIa, collagen and heparin. Mutations in this gene or deficiencies in this protein result in Von Willebrand's disease. VWD is characterized by frequent bleeding (gingival, minor skin quantitative lacerations, menorrhagia, etc.).

Function:
Important in the maintenance of hemostasis, it promotes adhesion of plaets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and plaet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma.

Subunit:
Multimeric. Interacts with F8.xy-13778R    5HT2C Receptor5-羥色胺受體2C抗體
xy-13779R    5HT5B Receptor5-羥色胺受體5B抗體
xy-8069R    SRRM4絲氨酸/精氨酸相關(guān)核基質(zhì)蛋白4抗體
xy-8068R    SRRM3絲氨酸/精氨酸相關(guān)核基質(zhì)蛋白3抗體
xy-7909R    phospho-CK II beta (Ser209)磷酸化絲氨酸/蘇氨酸蛋白激酶II β(casein kinase IIβ)抗體
xy-8060R    MOP5單核細胞蛋白5抗體
xy-9002R    SAMD9SAMD9蛋白抗體
xy-9001R    SARM1SARM1蛋白抗體
xy-9392R    p150 CAF1染色質(zhì)組裝因子1P155抗體
xy-11424R    Sauvagine蛙皮降壓肽抗體
xy-7927R    SIPA1L2信號誘導(dǎo)增殖相關(guān)蛋白1樣蛋白2抗體
xy-7922R    SKARDNA聚合酶δ相互作用蛋白3抗體
xy-7923R    SRPK2絲氨酸/蘇氨酸蛋白激酶SRPK2抗體
xy-6907R    Septin 8細胞分化蛋白SEPT8抗體
xy-7773R    SPECC1L細胞質(zhì)和紡錘體機化蛋白A抗體
xy-7769R    SEPT1細胞分化蛋白SEP1抗體
xy-7770R    SEPT10細胞分化蛋白SEPT10抗體
xy-7771R    SEPT12細胞分化蛋白SEPT12抗體
xy-11260R    SNIP1Smad核相互作用蛋白1抗體
xy-11261R    Syntaxin 6突觸融合蛋白6抗體
xy-11216R    Sprouty1軟脂?；椎鞍譙prouty1抗體
xy-11221R    SH3TC2脫髓鞘相關(guān)蛋白SH3TC2N抗體
xy-11238R    SHANK2富含脯氨酸突觸相關(guān)蛋白SHANK2抗體
xy-9581R    SHARPIN線性泛素鏈相關(guān)蛋白SHARPIN抗體
xy-9003R    SAMD7SAMD7蛋白抗體
xy-9004R    SAMD3SAMD3蛋白抗體
xy-11065R    Syntrophin gamma 2肌蛋白結(jié)合蛋白γ2抗體
xy-11207R    SOX22核轉(zhuǎn)錄因子SOX22抗體
xy-11208R    SOX4核轉(zhuǎn)錄因子SOX4抗體
xy-11209R    SUFU/Suppressor of Fused抑制Hh信號通路蛋白SUFU抗體