等電壓依賴性陰離子通道抗體 返回列表頁

等電壓依賴性陰離子通道抗體

英文名稱 VDAC
中文名稱 等電壓依賴性陰離子通道抗體
別    名 voltage-dependent anion channel; hVDAC1; MGC111064; Outer mitochondrial membrane protein porin 1; Plasmalemmal porin; Porin 31 HL; Porin 31HL; Porin 31HM; VDAC 1; VDAC; VDAC1; Voltage dependent anion channel 1; Voltage dependent anion selective channel protein 1; VTA1_HUMAN.

說 明 書 0.1ml  0.2ml  
研究領(lǐng)域 細(xì)胞生物  免疫學(xué)  細(xì)胞凋亡  通道蛋白  線粒體  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 32kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human VDAC
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
Voltage dependent anion selective channel protein 1 (VDAC/Porin) belongs to the eukaryotic mitochondrial porin family and forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel allows diffusion of small hydrophilic molecules; it adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation selective. VDAC/Porin expression is observed in the heart,liver and skeletal muscle.

Function:
Involved in the endosomal multivesicular bodies (MVB) pathway. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. Thought to be a cofactor of VPS4A/B, which catalyzes disassembles membrane-associated ESCRT-III assemblies. Involved in the sorting and down-regulation of EGFR (By similarity). Involved in HIV-1 budding.

Subunit:
Interacts with VPS4B. Interacts with CHMP1B. Interacts with CHMP2A; the interaction probably involves the open conformation of (polymerized) CHMP2A. May interact with CHMP3. Interacts with CHMP5; the interaction involves soluble CHMP5. Interacts with IST1.

Subcellular Location:
Cytoplasm. Endosome membrane; Peripheral membrane protein (Probable).

Similarity:
Belongs to the VTA1 family.

Gene ID:xy-4749R    Integrin beta 6整合素β6/Integrin β6抗體
xy-11256R    INPP5F磷酸肌醇磷酸酶蛋白INPP5抗體
xy-6841R    IL-4I1白細(xì)胞介素4誘導(dǎo)蛋白1抗體
xy-6840R    IEX1分化相關(guān)基因2蛋白/立即早期反應(yīng)蛋白抗體
xy-7637R    ICAM4細(xì)胞間粘附分子4抗體
xy-9633R    ITFG3整聯(lián)蛋白重復(fù)蛋白3抗體
xy-8683R    IGF2BP1胰島素樣生長因子ⅡmRNA結(jié)合蛋白1抗體
xy-8559R    IGF2BP2胰島素樣生長因子ⅡmRNA結(jié)合蛋白2抗體
xy-4847R    phospho-ITGB4(Tyr1530)磷酸化整合素β4抗體
xy-1822R    IGFBP1胰島素樣生長因子結(jié)合蛋白1抗體
xy-1823R    IGFBP4/IBP4胰島素樣生長因子結(jié)合蛋白4抗體
xy-1816R    ITGA7整合素α7抗體
xy-1811R    IL-7白介素7抗體
xy-1805R    IL-6R alpha白細(xì)胞介素6受體α/IL-6Rα抗體
xy-2428R    IL-9白介素9抗體
xy-1804R    Integrin alpha L整合素αL抗體Integrin αL
xy-1578R    Interferon alpha干擾素α抗體
xy-3402R    Phospho-INPPL1(Ser576)磷酸化肌醇聚磷酸鹽磷酸酶樣蛋白1抗體
xy-3404R    Phospho-INPPL1(Tyr986 + Tyr987)磷酸化肌醇聚磷酸鹽磷酸酶樣蛋白1抗體
xy-1826R    Inhibin Beta C抑制素βC抗體
xy-1830R    IL-16白介素16抗體
xy-1825R    Inhibin beta B抑制素βB/Inhibin β B抗體
xy-1827R    IL-11白介素11抗體
xy-2624R    IL-22R白介素22受體抗體
xy-2626R    IL-26/AK155白介素26抗體
xy-2612R    IL-17D/IL-27白介素-17D抗體
xy-15531R    IBRDC1環(huán)指蛋白217抗體
xy-0605R    IL-2白介素2抗體(人)
xy-1460R    IL-23R白介素-23受體抗體
xy-1434R    IGFBP3胰島素樣生長因子結(jié)合蛋白3抗體
xy-1459R    IL-6R Beta/CD130/gp130白細(xì)胞介素6受體β抗體IL-6Rβ
xy-1463R    IFNGR1干擾素-gamma受體1抗體
xy-10540R    IL-1 Alpha Propeptide白介素1α前肽/IL-1α前肽抗體