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泛素蛋白連接酶D3抗體

英文名稱 UBE2D3
中文名稱 泛素蛋白連接酶D3抗體
別    名 E2(17)KB3; MGC43926; MGC5416; UB2D3_HUMAN; UBC 4/5; UBC4/5; UBC4/5 homolog yeast; UBCH 5C; UBCH5C; Ube2d3; Ubiquitin carrier protein; Ubiquitin carrier protein D3; Ubiquitin conjugating enzyme E2 17 kDa 3; Ubiquitin conjugating enzyme E2 D3; Ubiquitin conjugating enzyme E2D 3 (homologous to yeast UBC4/5); Ubiquitin conjugating enzyme E2D 3 (UBC4/5 homolog yeast); Ubiquitin conjugating enzyme E2D 3; Ubiquitin protein ligase D3; Ubiquitin-conjugating enzyme E2 D3; Ubiquitin-conjugating enzyme E2(17)KB 3; Ubiquitin-conjugating enzyme E2-17 kDa 3; Ubiquitin-protein ligase D3.
   
說 明 書 0.2ml  
研究領(lǐng)域 腫瘤  細(xì)胞生物  免疫學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  表觀遺傳學(xué)  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, Chicken, Pig, Cow, Horse, Rabbit, Zebrafish, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 16 kDa
細(xì)胞定位 細(xì)胞膜 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human UBE2D3
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'-, as well as 'Lys-48'-linked polyubiquitination. Cooperates with the E2 CDC34 and the SCF(FBXW11) E3 ligase complex for the polyubiquitination of NFKBIA leading to its subsequent proteasomal degradation. Acts as an initiator E2, priming the phosphorylated NFKBIA target at positions 'Lys-21' and/or 'Lys-22' with a monoubiquitin. Ubiquitin chain elongation is then performed by CDC34, building ubiquitin chains from the UBE2D3-primed NFKBIA-linked ubiquitin. Acts also as an initiator E2, in conjunction with RNF8, for the priming of PCNA. Monoubiquitination of PCNA, and its subsequent polyubiquitination, are essential events in the operation of the DNA damage tolerance (DDT) pathway that is activated after DNA damage caused by UV or chemical agents during S-phase. Associates with the BRCA1/BARD1 E3 ligase complex to perform ubiquitination at DNA damage sites following ionizing radiation leading to DNA repair. Targets DAPK3 for ubiquitination which influences promyelocytic leukemia protein nuclear body (PML-NB) formation in the nucleus. In conjunction with the MDM2 and TOPORS E3 ligases, functions ubiquitination of p53/TP53. Supports NRDP1-mediated ubiquitination and degradation of ERBB3 and of BRUCE which triggers apoptosis. In conjunction with the CBL E3 ligase, targets EGFR for polyubiquitination at the plasma membrane as well as during its internalization and transport on endosomes. In conjunction with the STUB1 E3 quality control E3 ligase, ubiquitinates unfolded proteins to catalyze their immediate destruction.xy-8054R    KLHL10Kelch樣蛋白10抗體
xy-8055R    KLHL11Kelch樣蛋白11抗體
xy-8053R    KLHL3Kelch樣蛋白3抗體
xy-8056R    KLHL14Kelch樣蛋白14抗體
xy-8057R    KLHL31Kelch樣蛋白31抗體
xy-8058R    KLHL32Kelch樣蛋白32抗體
xy-1837R    KCNA5鉀電壓閥門通道混合器相關(guān)亞家族成員5抗體
xy-1838R    KLF10TGF-β誘導(dǎo)早期應(yīng)答基因1抗體
xy-1575R    KCNA3離子通道蛋白Kv1.3抗體
xy-2019R    phospho-KLF5(Ser272)磷酸化KLF5抗體
xy-2020R    phospho-KLF5(Ser275)磷酸化KLF5抗體
xy-1815R    ERG/KCNH2特異性鉀離子通道蛋白抗體
xy-7107R    KIF4A沉默驅(qū)動(dòng)蛋白KIF4A抗體
xy-6468R    kir 6.1ATP敏感鉀離子通道蛋白抗體
xy-13762R    KIAA1462KIAA1462蛋白抗體
xy-13763R    KIAA1549KIAA1549蛋白抗體
xy-4643R    KRV-VP1+KRV-VP2 (C-terminus)基爾曼氏細(xì)小病毒VP1/VP2抗體(大鼠潛在病毒KRV)C端
xy-7515R    KLHL20Kelch樣蛋白20抗體
xy-5786R    KLST激肽釋放酶抑制劑抗體
xy-5935R    KLHL7kelch樣蛋白7抗體
xy-5933R    KCNK 9TWIK相關(guān)酸敏感鉀離子通道蛋白9抗體
xy-5870R    KLK6激肽釋放酶6抗體
xy-5871R    KLK8激肽釋放酶8抗體
xy-5872R    KLKB1血漿激肽釋放酶抗體
xy-6529R    phospho-EZH2 (Thr487)磷酸化抑癌蛋白EZH2抗體
xy-6139R    KDM5B組蛋白去甲基化酶JARID1B抗體
xy-4144R    Keratan Sulfate硫酸角質(zhì)素抗體
xy-7719R    KRG2角質(zhì)細(xì)胞生長(zhǎng)因子調(diào)節(jié)蛋白2抗體
xy-2886R    KCNG4鉀離子通道蛋白G蛋白4抗體
xy-12178R    KCTD18鉀通道多聚體結(jié)構(gòu)域KCTD18抗體
xy-4900R    KEAP1胞質(zhì)接頭蛋白Keap1
xy-11861R    KALRN舞蹈癥相關(guān)蛋白KALRN抗體
xy-2084R    Kir4.1細(xì)胞內(nèi)流鉀通道蛋白Kir4.1抗體
xy-11864R    KIRREL3腎病樣蛋白3抗體
xy-11865R    KLF7KLF樣轉(zhuǎn)錄因子7抗體