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泛素載體蛋白L6抗體

英文名稱 Ube2L6
中文名稱 泛素載體蛋白L6抗體
別    名 Retinoic acid induced gene B protein; Retinoic acid-induced gene B protein; RIG B; RIG-B; UB2L6_HUMAN; UBCH 8; UBCH8; UBE2L6; Ubiquitin carrier protein; Ubiquitin carrier protein L6; Ubiquitin conjugating enzyme E2L 6; Ubiquitin protein ligase; Ubiquitin protein ligase L6; Ubiquitin-protein ligase L6; Ubiquitin/ISG15 conjugating enzyme E2 L6; Ubiquitin/ISG15-conjugating enzyme E2 L6.
  
說 明 書 0.2ml  
研究領(lǐng)域 細胞生物  免疫學(xué)  信號轉(zhuǎn)導(dǎo)  表觀遺傳學(xué)  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 18kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human Ube2L6
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
Ubiquitin is an abundant, highly conserved protein found in all eukaryotic cells, either free or covalently attached to cellular proteins. The primary function of ubiquitin in mammalian systems is to clear abnormal, foreign, and improperly folded proteins by targeting them for proteosome degradation. Ubiquitin conjugating enzyme 8 (UBC8) is an E2 enzyme involved in the ubiquitin pathway for protein degradation. Like other E2 enzymes, UBC8 forms a thioester bond with ubiquitin in an E1-dependent manner. UBC8 binds to the human homolog of Drosophila ariadne (HHARI) and UBC7-associated protein (H7-AP1) as well as double ring-finger protein (Dorfin). UBC8 is enriched in the central nervous system and interacts with Parkin, a RING-finger-containing protein implicated in the pathogenesis of familial Parkinson’s disease. Parkin shares sequence homology with other UBC8 binding proteins such as HHARI and H7-AP1.

Function:
Catalyzes the covalent attachment of ubiquitin or ISG15 to other proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Promotes ubiquitination and subsequent proteasomal degradation of FLT3.

Subunit:
Interacts with RNF19A, RNF19B and RNF144B. Interacts with FLT3 (tyrosine phosphorylated).

Tissue Specificity:
Present in natural killer cells.

Post-translational modifications:
ISGylated.xy-5765R    LANCL2G蛋白偶聯(lián)受體69B
xy-4581R    Listeria tropina李斯特菌菌體蛋白抗體
xy-4213R    LARGRho的鳥嘌呤核苷酸交換因子12抗體
xy-6395R    LEU5白血病相關(guān)蛋白5抗體
xy-7809R    LRRC62富含亮氨酸重復(fù)蛋白62抗體
xy-6963R    LPAP淋巴細胞磷蛋白磷酸酶相關(guān)蛋白抗體
xy-8303R    LGI4含亮氨酸神經(jīng)膠質(zhì)瘤失活蛋白4抗體
xy-8305R    LYL1淋巴細胞性白血病相關(guān)序列1抗體
xy-10255R    L-CitrullineL-瓜氨酸抗體
xy-3907R    Legumain半胱氨酸蛋白酶抗體
xy-6272R    LDHD乳酸脫氫酶D抗體
xy-3949R    LYK5蛋白激酶LYK5抗體
xy-10220R    lipotropin gamma促脂素gamma抗體
xy-5081R    Lamin B Receptor核纖層蛋白B受體抗體
xy-5076R    Ceramide synthase 1長壽相關(guān)基因lASS1抗體
xy-5080R    LASS6長壽相關(guān)基因lASS6抗體
xy-5082R    LASS5長壽相關(guān)基因lASS5抗體
xy-5078R    LASS3長壽相關(guān)基因lASS3抗體
xy-5077R    Ceramide synthase 2腫瘤轉(zhuǎn)移抑制基因1抗體
xy-5079R    LASS4長壽相關(guān)基因lASS4抗體
xy-6446R    Lin-28BRNA結(jié)合蛋白LIN28B抗體
xy-8443R    Lin28RNA結(jié)合蛋白LIN28抗體
xy-2336R    LPL protein內(nèi)皮脂肪酶抗體
xy-2576R    Ly-6G/Gr-1淋巴細胞抗原6G抗體
xy-6719R    LGI1富含亮氨酸膠質(zhì)瘤失活蛋白1抗體
xy-6713R    Laminin 5層粘連蛋白5(laminin γ2)抗體
xy-13756R    Lactoperoxidase唾液過氧化物酶LPO抗體
xy-10294R    lysozyme溶菌酶抗體
xy-10293R    lysozyme溶菌酶抗體
xy-13708R    LAD1LAD1蛋白抗體
xy-13709R    LAP2 alpha胸腺生成素LAP2抗體
xy-13613R    LRRC6富含亮氨酸重復(fù)蛋白6抗體