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泛素蛋白連接酶G1抗體

英文名稱 Ube2G1
中文名稱 泛素蛋白連接酶G1抗體
別    名 E217K; UB2G1_HUMAN; UBC 7; UBC7; UBC7 homolog yeast; UBE 2G; UBE2G; Ube2g1; Ubiquitin carrier protein G1; Ubiquitin conjugating enzyme E2 G1; Ubiquitin conjugating enzyme E2G 1 (homologous to C. elegans UBC7); Ubiquitin conjugating enzyme E2G 1 (UBC7 homolog C. elegans); Ubiquitin conjugating enzyme E2G 1 (UBC7 homolog yeast); Ubiquitin conjugating enzyme E2G 1; Ubiquitin protein ligase G1; Ubiquitin-conjugating enzyme E2 G1; Ubiquitin-protein ligase G1.

說 明 書 0.1ml  0.2ml  
研究領(lǐng)域 細(xì)胞生物  免疫學(xué)  表觀遺傳學(xué)  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Mouse, Rat, Dog, Pig, Horse, Rabbit, Sheep, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 19kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human Ube2G1/UBC7
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
Ubiquitin is an abundant, highly conserved protein found in all eukaryotic cells either free or covalently attached to cellular proteins. The primary function of ubiquitin in mammalian systems is to clear abnormal, foreign, and improperly folded proteins by targeting them for proteosome degradation. In Saccharomyces cerevisiae, ubiquitin-like proteins include Rub1, Ula1, Uba3, Smt3, Ubc2, Ubc12 and Ubc9. Rub1 shares 53% homology with ubiquitin and requires activation via the E2 proteins, including Ula1, Uba3 and Ubc12 in order to conjugate to substrates directed to different proteolytic systems. Ubc4 catalyzes ubiquitination of IkBa in a phosphorylation and SCFB-TRCP dependent manner. In this particular reaction, E1 first transfers ubiquitin to the E2 component Ubc4, and Ubc4 then associates with E3 ligase, which conjugates the poly-ubiquitin chain on a target protein. In this fashion, the chain tags the IkBa for degradation by a proteasome thus lifting the inhibitory effect of IkBa on NFkB and allowing NFkB to enter the nucleus.

Function:
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination. May be involved in degradation of muscle-specific proteins. Mediates polyubiquitination of CYP3A4.xy-2912R    LC3B/MAP LC3β/MAP1A自噬微管相關(guān)蛋白輕鏈3抗體
xy-11780R    LMX1b指甲髕骨綜合征相關(guān)蛋白NPS1抗體
xy-4843R    LC3B自噬微管相關(guān)蛋白輕鏈β3抗體
xy-8361R    LRRC59LRRC59蛋白抗體
xy-8362R    LRRC41LRRC41蛋白抗體
xy-6431R    LHR促黃體生成素受體抗體
xy-11131R    alpha Lactalbumin乳清蛋白α抗體
xy-11132R    Lamin B2核纖層蛋白B2抗體
xy-1086R    Laminin alpha 5層粘蛋白α5抗體
xy-0619R    L-CitrullineL-瓜氨酸抗體
xy-9487R    LACE1泌乳升高蛋白1抗體
xy-9562R    LAPTM4A溶酶體相關(guān)膜蛋白4α抗體
xy-9563R    DIF14分化相關(guān)基因14抗體
xy-9561R    LACTB2β內(nèi)酰胺酶樣蛋白2抗體
xy-11088R    LRFN3神經(jīng)突觸粘附樣分子4抗體
xy-5729R    LGALS3BP可溶性半乳糖凝集素3結(jié)合蛋白抗體
xy-4604R    Leptin瘦素抗體
xy-7533R    Lipin 1磷脂酸磷酸酯酶LPIN1抗體
xy-8609R    LGR6G蛋白偶聯(lián)受體6抗體
xy-3801R    Lambda Light Chainλ輕鏈抗體
xy-2379R    LAMP2溶酶體相關(guān)膜蛋白2抗體
xy-9672R    LAS2肺腺瘤易感蛋白2抗體
xy-5410R    phospho-LEO1(Ser551)磷酸化RNA聚合酶相關(guān)蛋白LEO1抗體
xy-4081R    LATS2腫瘤抑制基因LATS2抗體
xy-5155R    phospho-LSP1 (Ser204)磷酸化白細(xì)胞F肌動(dòng)蛋白結(jié)合蛋白抗體
xy-4082R    phospho-LATS2 (Ser83)磷酸化腫瘤抑制基因LATS2抗體
xy-5156R    phospho-LSP1 (Ser252)磷酸化白細(xì)胞F肌動(dòng)蛋白結(jié)合蛋白抗體
xy-5154R    LSP1白細(xì)胞F肌動(dòng)蛋白結(jié)合蛋白抗體
xy-5138R    LZTFL1亮氨酸拉鏈轉(zhuǎn)錄因子樣1抗體
xy-5122R    Laminin B2 gamma 1層粘連蛋白B2γ1抗體
xy-10127R    Phospho-LAT (Tyr161)磷酸化T細(xì)胞活化連接蛋白抗體
xy-10128R    Phospho-LAT (Tyr200)磷酸化T細(xì)胞活化連接蛋白抗體