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泛素結(jié)合酶E2蛋白A抗體

英文名稱 UBE2A
中文名稱 泛素結(jié)合酶E2蛋白A抗體
別    名 BHR6A; hHR6A; HR6A; mHR6A; RAD6 homolog A; RAD6A; RAD6B; UBC-1; UBC2; UBC6; UBCD6; UBE2A; UBE2A_HUMAN; UBE2B; Ubiquitin carrier protein A; Ubiquitin carrier protein; Ubiquitin conjugating enzyme E2 17 kDa; Ubiquitin conjugating enzyme E2 21.5 kDa; Ubiquitin conjugating enzyme E2 A; Ubiquitin protein ligase A; Ubiquitin-conjugating enzyme E2 A; Ubiquitin-conjugating enzyme E2-17 kDa; Ubiquitin-conjugating enzyme E2-21.5 kDa; Ubiquitin-protein ligase A.

說(shuō) 明 書(shū) 0.2ml  
研究領(lǐng)域 細(xì)胞生物  免疫學(xué)  表觀遺傳學(xué)  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, Chicken, Cow, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 17kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human UBE2A/UBE2B/RAD6
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
The ubiquitin (Ub) pathway involves three sequential enzymatic steps that facilitate the conjugation of Ub and Ub-like molecules to specific protein substrates. The first step requires the ATP-dependent activation of the Ub C-terminus and the assembly of multi-Ub chains by the Ub-activating enzyme known as the E1 component. The Ub chain is then conjugated to the Ub-conjugating enzyme (E2) to generate an intermediate Ub-E2 complex. The Ub-ligase (E3) then catalyzes the transfer of Ub from E2 to the appropriate protein substrate. UBE2A (Ubiquitin-conjugating enzyme E2 A) and UBE2B (Ubiquitin-conjugating enzyme E2 B) are both Ub-conjugating enzymes that are essential to postreplication repair of UV-damaged DNA. UBE2A and UBE2B are both nuclear and cell membrane proteins that have been found to interact with Rad18.

Function:
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In association with the E3 enzyme BRE1 (RNF20 and/or RNF40), it plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B at 'Lys-120' to form H2BK120ub1. H2BK120ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, omeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. In vitro catalyzes 'Lys-11', as well as 'Lys-48'-linked polyubiquitination. Required for postreplication repair of UV-damaged DNA.

Subunit:
Interacts with RAD18 and WAC.xy-4973R    Laminin alpha 1層粘蛋白α1抗體
xy-15591R    LETM1LETM1蛋白抗體
xy-1810R    LDHA乳酸脫氫酶抗體
xy-1532R    phospho-LKB1 (Thr363)磷酸化絲氨酸/蘇氨酸蛋白激酶抗體
xy-1526R    Laminin Beta 1層粘連蛋白β1抗體
xy-0976R    LPLUNC1鼻咽癌癌基因抗體
xy-1458R    LIFR白血病抑制因子受體抗體
xy-1839R    lamin A + C核纖層蛋白A抗體
xy-1840R    Lamin B核纖層蛋白B抗體(細(xì)胞核膜標(biāo)志物)
xy-1841R    lamin A + C核纖層蛋白A/C抗體
xy-1845R    LRIG2LRIG2抗體
xy-1843R    LEF-1淋巴增強(qiáng)因子-1抗體
xy-1844R    LRIG1LRIG1抗體
xy-1846R    LRIG3LRIG3抗體
xy-1617R    LI-cadherin肝腸鈣粘連蛋白抗體
xy-1842R    Layilin透明質(zhì)酸受體抗體
xy-9649R    C17orf8217號(hào)染色體開(kāi)放閱讀框82抗體
xy-11874R    LMCD1轉(zhuǎn)錄因子LMCD1抗體
xy-12336R    Ly76淋巴細(xì)胞抗原76抗體
xy-9509R    LRP15富含亮氨酸重復(fù)序列LRP15抗體
xy-11213R    LRRTM1富含亮氨酸重復(fù)跨膜神經(jīng)元蛋白1抗體
xy-8561R    Laminin 2 alpha層粘蛋白α2抗體
xy-6762R    LIPG內(nèi)皮脂肪酶抗體
xy-4206R    sLOX 1可溶性凝集素樣氧化低密度脂蛋白受體1抗體
xy-7504R    Laminin Beta 2層粘連蛋白β2抗體
xy-7516R    LECT1白細(xì)胞衍生化學(xué)吸引素抗體
xy-8430R    LMO2T淋巴細(xì)胞易位蛋白2抗體
xy-11463R    Liprin alpha 1酪氨酸磷酸酶受體相互作用蛋白Liprin α1抗體
xy-4245R    LONP1線粒體離子肽酶1抗體
xy-6230R    LC3C微管相關(guān)蛋白輕鏈3C抗體
xy-5705R    LZTS1假定腫瘤抑制亮氨酸拉鏈蛋白1抗體
xy-3827R    LDHC(Cancer,testis antigen 32)乳酸脫氫酶LDH-C（腫瘤/睪丸抗原32）抗體