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去泛素化酶3抗體

英文名稱 USP3
中文名稱 去泛素化酶3抗體
別    名 Deubiquitinating enzyme 3; EC 3.1.2.15; SIH003; Ubiquitin carboxyl-terminal hydrolase 3; Ubiquitin specific peptidase 3; Ubiquitin specific processing protease 3; Ubiquitin Specific Protease 3; Ubiquitin thioesterase 3; Ubiquitin thiolesterase 3; Ubiquitin-specific-processing protease 3; UBP; UBP3_HUMAN; Usp3.

說 明 書 0.2ml  
研究領(lǐng)域 腫瘤  細(xì)胞生物  免疫學(xué)  染色質(zhì)和核信號(hào)  信號(hào)轉(zhuǎn)導(dǎo)  激酶和磷酸酶  表觀遺傳學(xué)  泛素  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 59kDa
細(xì)胞定位 細(xì)胞核 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human USP3
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
The ubiquitin (Ub) pathway involves three sequential enzymatic steps that facilitate the conjugation of Ub and Ub-like molecules to specific protein substrates. Through the use of a wide range of enzymes that can add or remove ubiquitin, the Ub pathway controls many intracellular processes such as signal transduction, transcriptional activation and cell cycle progression. USP3 (ubiquitin specific peptidase 3), also known as UBP or SIH003, is a 520 amino acid protein that contains one UBP-type zinc finger and belongs to the peptidase C19 family. Expressed ubiquitously with highest levels present in pancreas, USP3 catalyzes the conversion of a ubiquitin C-terminal thioester to a free ubiquitin and a thiol. The gene encoding USP3 maps to human chromosome 15, which houses over 700 genes and comprises nearly 3% of the human genome.

Function:
Hydrolase that deubiquitinates monoubiquitinated target proteins such as histone H2A and H2B. Required for proper progression through S phase and subsequent mitotic entry. May regulate the DNA damage response (DDR) checkpoint through deubiquitination of H2A at DNA damage sites. Associates with the chromatin. 

Subunit:
Interacts (via UBP-type domain) with H2A; the interaction is less efficient than with monoubiquitinated H2A. xy-3629R    MEG1蛋白酪氨酸磷酸酶非受體型4抗體
xy-13355R    MBOAT4腦腸肽O酰基轉(zhuǎn)移酶抗體
xy-5272R    MRG15轉(zhuǎn)錄調(diào)控因子MRG15抗體
xy-5273R    MLL5髓系/淋巴混合譜系白血病蛋白5抗體
xy-4835R    MPV17T淋巴細(xì)胞成熟相關(guān)蛋白抗體
xy-9961R    cblA甲基丙二酸尿癥cblA抗體
xy-8564R    non-muscle Myosin IIA非平滑肌肌球蛋白2A抗體
xy-8671R    MMS19DNA修復(fù)甲基磺酸敏感性基因19抗體
xy-9680R    C19orf2819號(hào)染色體開放閱讀框28抗體
xy-3802R    Mammaglobin A乳腺珠蛋白1抗體
xy-3805R    Myoglobin肌紅蛋白抗體
xy-3804R    MSH6錯(cuò)配修復(fù)蛋白6抗體
xy-3803R    Mammaglobin B乳腺珠蛋白2抗體
xy-6387R    MEI-1減數(shù)分裂缺陷蛋白1抗體
xy-7630R    MTCH1細(xì)胞增殖誘導(dǎo)蛋白60（早老素相關(guān)蛋白）
xy-7631R    MTCH2線粒體載體同源蛋白2抗體
xy-7632R    MTFR1線粒體裂變調(diào)節(jié)蛋白1抗體
xy-7633R    MTP18線粒體蛋白18抗體
xy-7629R    MICS1生長(zhǎng)激素誘導(dǎo)跨膜蛋白抗體（真皮乳頭源性蛋白2）
xy-7628R    MFF線粒體裂變因子MFF抗體
xy-2256R    Mouse serum albumin小鼠血清白蛋白抗體
xy-11417R    MC4 Receptor黑素皮質(zhì)素4受體抗體
xy-11418R    MC5 Receptor黑素皮質(zhì)素受體5抗體
xy-11434R    MOT8甲狀腺激素轉(zhuǎn)運(yùn)蛋白/單羧酸轉(zhuǎn)運(yùn)蛋白7/8抗體
xy-5741R    MARK2絲氨酸/蘇氨酸蛋白激酶MARK2抗體
xy-5742R    phospho-MARK2(Thr596)磷酸化絲氨酸/蘇氨酸蛋白激酶MARK2抗體
xy-7059R    MMP-9基質(zhì)金屬蛋白酶9抗體
xy-4634R    Phospho-Mst2(Thr180)磷酸化蛋白激酶MST2抗體
xy-4635R    Phospho-Mst1(Thr183)磷酸化蛋白激酶MST1抗體
xy-5763R    MRP9多藥耐藥相關(guān)蛋白9抗體
xy-4605R    MMP-2基質(zhì)金屬蛋白酶-2抗體
xy-4599R    MMP-2基質(zhì)金屬蛋白酶2抗體
xy-5731R    Mad2L1有絲分裂阻滯缺陷2樣蛋白1抗體
xy-5730R    MAD2有絲分裂阻滯缺陷蛋白2抗體
xy-6294R    beta 2 Microglobulinβ2微球蛋白抗體
xy-6269R    phospho-MCK10 (Tyr513)磷酸化神經(jīng)上皮酪氨酸激酶/乳腺癌激酶10抗體