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去泛素酶10抗體

英文名稱 USP10
中文名稱 去泛素酶10抗體
別    名 Deubiquitinating enzyme 10; Ubiquitin carboxyl terminal hydrolase 10; Ubiquitin carboxyl-terminal hydrolase 10; Ubiquitin specific peptidase 10; Ubiquitin specific processing protease 10; Ubiquitin specific protease 10; Ubiquitin thioesterase 10; Ubiquitin thiolesterase 10; Ubiquitin-specific-processing protease 10; UBP10_HUMAN; UBPO; USP 10; USP10.
 
說(shuō) 明 書(shū) 0.2ml  
研究領(lǐng)域 腫瘤  細(xì)胞生物  表觀遺傳學(xué)  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, Chicken, Dog, Pig, Horse, Rabbit, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 87kDa
細(xì)胞定位 細(xì)胞核 細(xì)胞漿 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human USP10
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

產(chǎn)品介紹 background:
Ubiquitin is a highly conserved protein that is covalently linked to other proteins to regulate their function and degradation. This gene encodes a member of the ubiquitin-specific protease family of cysteine proteases. The enzyme specifically cleaves ubiquitin from ubiquitin-conjugated protein substrates. The protein is found in the nucleus and cytoplasm. It functions as a co-factor of the DNA-bound androgen receptor complex, and is inhibited by a protein in the Ras-GTPase pathway. The human genome contains several pseudogenes similar to this gene. Several transcript variants, some protein-coding and others not protein-coding, have been found for this gene. [provided by RefSeq, Jan 2013]. 

Function:
Hydrolase that can remove conjugated ubiquitin from target proteins such as p53/TP53, BECN1, SNX3 and CFTR. Acts as an essential regulator of p53/TP53 stability: in unstressed cells, specifically deubiquitinates p53/TP53 in the cytoplasm, leading to counteract MDM2 action and stabilize p53/TP53. Following DNA damage, translocates to the nucleus and deubiquitinates p53/TP53, leading to regulate the p53/TP53-dependent DNA damage response. Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes. In turn, PIK3C3/VPS34-containing complexes regulate USP10 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13. Does not deubiquitinate MDM2. Deubiquitinates CFTR in early endosomes, enhancing its endocytic recycling. 

Subunit:
Interacts with G3BP, which may regulate its function. Interacts with p53/TP53, SNX3 and CFTR.

Subcellular Location:
Cytoplasm. Nucleus. Early endosome. Note=Cytoplasmic in normal conditions. After DNA damage, translocates to the nucleus following phosphorylation by ATM.

Tissue Specificity:
Widely expressed.xy-2998R    MYPT1肌球蛋白磷酸酶抗體
xy-3285R    Phospho-MYPT1 (Ser507)磷酸化肌球蛋白磷酸酶抗體
xy-3286R    Phospho-MYPT1 (Ser668)磷酸化肌球蛋白磷酸酶抗體
xy-3287R    Phospho-MYPT1(Thr696)磷酸化肌球蛋白磷酸酶抗體
xy-3288R    Phospho-MYPT1 (Thr853)磷酸化肌球蛋白磷酸酶抗體
xy-3273R    Phospho-Met (Tyr1349)磷酸化肝細(xì)胞生長(zhǎng)因子受體(原癌基因)抗體
xy-2911R    MEK6絲裂原活化蛋白激酶MKK6抗體
xy-3274R    Phospho-MKK3(Ser218) + MKK6(Ser207) 磷酸化絲裂原活化蛋白激酶MKK3/6抗體
xy-3275R    Phospho-MEK6 (Ser207)磷酸化絲裂原活化蛋白激酶MKK6抗體
xy-1761R    MDC嗜酸粒細(xì)胞趨化蛋白22抗體
xy-1759R    Met Enkephalin甲硫氨酸腦啡肽抗體
xy-2129R    Morphine嗎啡抗體
xy-2099R    MMP-9基質(zhì)金屬蛋白酶9抗體
xy-1882R    MRas原癌基因M-ras抗體
xy-1955R    MCP1單核細(xì)胞趨化蛋白1抗體
xy-2029R    Morphine嗎啡抗體
xy-1676R    MG雞毒支原體抗體
xy-8520R    MtTF1線粒體轉(zhuǎn)錄因子1抗體
xy-1595R    MAD1有絲分裂抑制缺陷蛋白1抗體
xy-9344R    MARCH10膜相關(guān)環(huán)指蛋白10抗體
xy-6863R    MALT1粘膜相關(guān)淋巴組織淋巴瘤轉(zhuǎn)運(yùn)蛋白1抗體
xy-0642R    MAdCAM-1粘膜血管定居因子抗體
xy-0792R    Maspin抑癌基因抗體
xy-0671R    MCK10神經(jīng)上皮酪氨酸激酶/乳腺癌激酶10抗體
xy-0832R    MICAMHC I類鏈相關(guān)蛋白A/組織相容性復(fù)合物MHCIa抗體
xy-0762R    Midnolin中腦核仁蛋白抗體
xy-1044R    MIF巨噬細(xì)胞移動(dòng)抑制因子抗體
xy-1045R    CCL3巨噬細(xì)胞炎癥因子1α抗體 MIP-1α
xy-1150R    muscarinic Acetylcholine Receptor 1毒蕈堿型乙酰膽堿受體M1抗體
xy-0257R    MAG髓鞘相關(guān)糖蛋白a/b抗體
xy-1041R    MEK1 + MEK2絲裂原活化蛋白激酶激酶1抗體
xy-0223R    MEK2絲裂原活化蛋白激酶激酶2抗體
xy-0531R    Matriptase蛋白裂解酶（一種新的癌基因）抗體
xy-0380R    MBP髓鞘堿性蛋白/磷脂堿性蛋白抗體
xy-0051R    MelanA黑色素瘤相關(guān)抗原/黑色素-A抗體
xy-1101R    MCP1單核細(xì)胞趨化蛋白1抗體