泛素融合降解樣蛋白1抗體 返回列表頁

泛素融合降解樣蛋白1抗體

英文名稱 UFD1L
中文名稱 泛素融合降解樣蛋白1抗體
別    名 UB fusion protein 1; Ubiquitin fusion degradation 1 like (yeast); Ubiquitin fusion degradation 1 like; Ubiquitin fusion degradation protein 1 homolog; UFD1; UFD1L.
 
說 明 書 0.1ml  0.2ml  
研究領(lǐng)域 細(xì)胞生物  信號(hào)轉(zhuǎn)導(dǎo)  細(xì)胞周期蛋白  細(xì)胞分化  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, Chicken, Dog, Pig, Cow, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 34kDa
細(xì)胞定位 細(xì)胞核 細(xì)胞漿 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human UFD1L
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
UFD1L is a member of the UFD1 family of proteins and is a component of the ubiquitin-dependent proteolytic pathway which degrades ubiquitin fusion proteins. This complex, also containing UFD1L, VCP and NPLOC4, binds ubiquitinated proteins and is required for the export of misfolded proteins from the ER to the cytoplasm for disposal. The NPLOC4-UFD1L-VCP complex also regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. UFD1L gene hemizygosity is the cause of some developmental defects including DiGeorge syndrome (DGS), velo-cardio-facial syndrome (VCFS) and Opitz G/BBB syndrome. UFD1L has 2 named isoforms produced by alternative splicing.

Function:
Essential component of the ubiquitin-dependent proteolytic pathway which degrades ubiquitin fusion proteins. The ternary complex containing UFD1L, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1L-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. It may be involved in the development of some ectoderm-derived structures.

Subunit:
Heterodimer with NPLOC4, this heterodimer binds VCP and inhibits Golgi membrane fusion. Interacts with USP13.xy-7754R    BBS6巴德-畢德氏綜合征蛋白BBS6抗體
xy-7750R    MKLP2有絲分裂驅(qū)動(dòng)蛋白樣2抗體
xy-7810R    MFAP1微原纖維膠原相關(guān)蛋白1抗體
xy-7799R    MND1減數(shù)分裂核分裂蛋白1抗體
xy-6386R    MDFIC肌原調(diào)節(jié)抑制蛋白抗體
xy-6388R    MDM2BP雙微體2癌基因結(jié)合蛋白抗體
xy-5788R    MMP20基質(zhì)金屬蛋白酶20
xy-5762R    MRP8多藥耐藥相關(guān)蛋白8抗體
xy-5761R    MRP7多藥耐藥相關(guān)蛋白7抗體
xy-5753R    phospho-MLF1 Interacting Protein(Thr78)磷酸化卡波西氏肉瘤皰疹病毒潛伏核抗原相互作用蛋白1抗體
xy-5751R    MATK酪氨酸蛋白激酶細(xì)胞分裂素抗體
xy-5752R    MLF1 Interacting Protein卡波西氏肉瘤皰疹病毒潛伏核抗原相互作用蛋白1抗體
xy-6231R    MAGEF1黑色素瘤抗原F蛋白家族1抗體
xy-5841R    MGAT5糖蛋白GNTVA抗體
xy-5842R    MIIPIGFBP2結(jié)合蛋白/遷移和侵潤抑制蛋白抗體
xy-11028R    MAP1B微管相關(guān)蛋白1B抗體
xy-4919R    MSH3錯(cuò)配修復(fù)蛋白3抗體
xy-11092R    MDGA2神經(jīng)元膜糖蛋白錨定蛋白2抗體
xy-11038R    MYRIPMYRIP蛋白抗體
xy-11093R    Myelin PLP髓磷酯髓鞘蛋白1抗體
xy-4910R    MCSF巨噬細(xì)胞克隆刺激因子抗體
xy-9338R    MARCH4膜相關(guān)環(huán)指蛋白4抗體
xy-4705R    MLCK肌球蛋白輕鏈激酶抗體
xy-7850R    MPS1單極紡錘體蛋白激酶1抗體
xy-7840R    Mad2L2有絲分裂阻滯缺陷2樣蛋白2抗體
xy-11297R    Monoamine Oxidase B單胺氧化酶B抗體
xy-11298R    MCM4微小染色體維持缺陷蛋白4抗體
xy-1534R    MAP1LC3A自噬微管相關(guān)蛋白輕鏈3抗體
xy-11191R    MRF/C11orf9髓鞘基因調(diào)控因子抗體
xy-11034R    MYBPC1肌球蛋白結(jié)合蛋白C抗體
xy-3678R    Phospho-MKP1 (Ser318)磷酸化絲裂原活化蛋白激酶磷酸酶1抗體
xy-1161R    Metabotropic glutamate receptor 2促代謝型谷氨酸受體2抗體
xy-1237R    MGLUR3代謝型谷氨酸受體-3抗體
xy-1162R    CXCL2巨噬細(xì)胞炎癥蛋白2（ GRＯβ）抗體
xy-1328R    Metallothionein金屬硫蛋白抗體