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腫瘤抑制基因UVRAG抗體

英文名稱 UVRAG
中文名稱 腫瘤抑制基因UVRAG抗體
別    名 DHTX; Disrupted in heterotaxy; p63; UV radiation resistance associated; UV radiation resistance associated gene; UV radiation resistance associated gene protein; UV radiation resistance-associated gene protein; UVRAG; UVRAG_HUMAN.

說 明 書 0.1ml  0.2ml  
研究領(lǐng)域 腫瘤  心血管  免疫學(xué)  信號轉(zhuǎn)導(dǎo)  轉(zhuǎn)錄調(diào)節(jié)因子  表觀遺傳學(xué)  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, Dog, Horse, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 78kDa
細(xì)胞定位 細(xì)胞漿 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from Human UVRAG/DHTX
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
UVRAG, also known as p63 or DHTX, is a 699 amino acid cytoplasmic protein. UVRAG has been shown to activate the BECN1/PI 3-kinase complex, which promotes autophagy. Autophagy is the degradation of cellular proteins in the lysosomes, and when this pathway is suppressed, cell growth is deregulated. Mutations in the gene encoding UVRAG have been associated with colon cancer, suggesting that UVRAG is also involved in suppressing the proliferation and tumorigenicity of human colon cancer cells. UVRAG has been found to complement the ultraviolet sensitivity of xeroderma pigmentosum group C cells. Ubiquitously expressed, UVRAG is found at highest levels in kidney, lung, liver and brain. UVRAG contains one C2 domain, which is thought to be involved in calcium-dependent phospholipid binding.

Subunit:
Forms a complex with BECN1, PIK3C3 and PIK3R4. A subpopulation of these complexes also harbor KIAA0226/Rubicon. UVRAG-containing complexes never including ATG14, both forming mutually exclusive complexes with BECN1 through direct competition. Directly interacts with FEZ1 and SCOC. The interaction with SCOC is reduced by amino acid starvation, but the complex is stabilized in the presence of FEZ1. 

Subcellular Location:
Late endosome. Lysosome. Early endosome. Colocalizes with RAB9-positive compartments involved in retrograde transport from late endosomes to trans-Golgi network. Colocalization with early endosomes is only partial.

Tissue Specificity:
Highly expressed in brain, lung, kidney and liver.

DISEASE:
Note=A chromosomal aberration involving UVRAG has been observed in a patient with heterotaxy (left-right axis malformation). Inversion Inv(11)(q13.5;q25). xy-3259R    Phospho-MAP2(Ser136)磷酸化微管相關(guān)蛋白2抗體
xy-9899R    MMRN1內(nèi)皮細(xì)胞MMRN1蛋白抗體
xy-3270R    Phospho-MEK1/2 (Ser218 + Ser222)磷酸化絲裂原活化蛋白激酶激酶1/2抗體
xy-3271R    Phospho-Met (c-Met) (Tyr1003)磷酸化肝細(xì)胞生長因子受體(原癌基因)抗體
xy-3272R    Phospho-Met (Tyr1234 + Tyr1235)磷酸化肝細(xì)胞生長因子受體(原癌基因)抗體
xy-3265R    Phospho-Mcl1 (Ser159 + Thr163)磷酸化髓樣細(xì)胞白血病-1抗體
xy-3266R    Phospho-MDM2 (Ser166)磷酸化雙微體2癌基因抗體
xy-3267R    Phospho-MEF2A (Thr312)磷酸化肌細(xì)胞增強(qiáng)因子2抗體
xy-3268R    Phospho-MEF2A (Ser408)磷酸化肌細(xì)胞增強(qiáng)因子2抗體
xy-3269R    phospho-MEK1 (Thr286)磷酸化絲裂原活化蛋白激酶激酶1抗體
xy-3260R    Phospho-MAP2 (Thr1620 + Thr1623)磷酸化微管相關(guān)蛋白2抗體
xy-2908R    MAPKAP Kinase 2絲裂原活化蛋白激酶活化的蛋白激酶2抗體
xy-3261R    Phospho-MAPKAPK2 (Thr222)磷酸化絲裂原活化蛋白激酶活化的蛋白激酶2抗體
xy-3262R    Phospho-MAPKAPK2(Thr334)磷酸化絲裂原活化蛋白激酶活化的蛋白激酶2抗體
xy-3263R    Phospho-MARCKS (Ser152 + Ser156)磷酸化丙氨酸蛋白激酶C底物Marcks抗體
xy-3359R    Phospho-MARCKS (Ser162)磷酸化丙氨酸蛋白激酶C底物Marcks抗體
xy-0668R    Met (c Met)肝細(xì)胞生長因子受體抗體
xy-6779R    phospho-MAP3K9+MAP3K10(Thr312 + Thr266)磷酸化絲裂原活化蛋白激酶3K9抗體
xy-6780R    TYRO3受體酪氨酸激酶抗體
xy-6778R    MAP3K9絲裂原活化蛋白激酶3K9抗體
xy-7558R    MC3 Receptor黑素皮質(zhì)素3受體抗體
xy-1988R    MeninMenin抑癌蛋白抗體
xy-8542R    MSH3錯(cuò)配修復(fù)蛋白3抗體
xy-1983R    MCM7微小染色體維持缺陷蛋白7抗體
xy-1985R    MCP-2單核細(xì)胞趨化蛋白2抗體(小鼠)
xy-1986R    MCP-3單核細(xì)胞趨化蛋白3抗體
xy-1987R    MCP-3單核細(xì)胞趨化蛋白3抗體
xy-1989R    MIP4巨噬細(xì)胞炎癥蛋白18抗體
xy-1990R    MITFMITF相關(guān)轉(zhuǎn)錄因子抗體
xy-1992R    MTOR雷帕霉素靶蛋白抗體
xy-1993R    Muc2粘蛋白-2/上皮膜抗原2抗體
xy-1994R    Mucin 4粘蛋白4抗體
xy-0924R    Mafav-maf 肌腱膜纖維肉瘤癌基因同源物A抗體
xy-1344R    MMP-10基質(zhì)金屬蛋白酶-10抗體
xy-0913R    Mtp53(N235K N239Y)突變型P53抗體