肌營(yíng)養(yǎng)不良蛋白相關(guān)蛋白1抗體 返回列表頁(yè)

肌營(yíng)養(yǎng)不良蛋白相關(guān)蛋白1抗體

英文名稱 Utrophin
中文名稱 肌營(yíng)養(yǎng)不良蛋白相關(guān)蛋白1抗體
別    名 DMDL; DRP 1; DRP; DRP-1; DRP1; Dystrophin like protein; Dystrophin related protein 1; Dystrophin related protein; Dystrophin-related protein 1; FLJ23678; UTRN; UTRO_HUMAN; Utrophin (homologous to dystrophin); Utrophin

說 明 書 0.1ml  0.2ml  
研究領(lǐng)域 細(xì)胞生物  神經(jīng)生物學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  結(jié)合蛋白  細(xì)胞骨架  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Sheep, 
產(chǎn)品應(yīng)用 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 394kDa
細(xì)胞定位 細(xì)胞漿 細(xì)胞膜 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human Utrophin (3110-3156aa)
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
Dystrophin and utrophin are related structural, Actin-binding proteins that are involved in anchoring the cytoskeleton to the plasma membrane. Dystrophin is the protein product of the Duchenne/Becker muscular dystrophy gene. Dystrophin expression is found in muscle and brain tissues, where it is localized to the inner surface of the plasma membrane. It has been speculated that alternative splicing of the carboxy terminus allows dystrophin to interact with a variety of proteins. Research has shown that the loss of dystrophin-associated proteins in Duchenne afflicted muscle is due to the absence of dystrophin rather than to muscle degradation and that the lack of dystrophin results in the loss of linkage between the cytoskeleton and the extracellular matrix. Evidence suggests that the upregulation of utrophin can reduce the dystrophic pathology.

Function:
May play a role in anchoring the cytoskeleton to the plasma membrane.

Subunit:
Interacts with the syntrophins SNTA1; SNTB1 and SNTB2. Interacts with SYNM. Interacts (via its WWW and ZZ domains) with DAG1 (via the PPXY motif of betaDAG1); the interaction is inhibited by the tyrosine phosphorylation of the PPXY motif of DAG1. 

Subcellular Location:
Cell junction > synapse > postsynaptic cell membrane. Cytoplasm > cytoskeleton. Neuromuscular junction.

Tissue Specificity:
Muscle.

Similarity:
Contains 2 CH (calponin-homology) domains.
Contains 20 spectrin repeats.
Contains 1 WW domain.
Contains 1 ZZ-type zinc finger.

Database links:
UniProtKB/Swiss-Prot: P46939.2xy-11103R    Netrin G1/G2軸突生長(zhǎng)誘向因子G2抗體
xy-11192R    NG2黑色素瘤硫酸軟骨素蛋白多糖4抗體
xy-9891R    NDST1NDST1蛋白抗體
xy-11299R    NAB2EGR1結(jié)合蛋白2抗體
xy-9587R    Alpha-synuclein (nitro-Tyr39)硝基化α-突觸核蛋白
xy-11302R    Nkx2.2NK2轉(zhuǎn)錄樣蛋白B抗體
xy-4893R    NPTX1神經(jīng)細(xì)胞正五聚體1抗體
xy-7843R    NUP160核孔蛋白NUP160抗體
xy-7841R    NUDC細(xì)胞核分離基因C蛋白抗體
xy-7842R    phospho-NUDC(Ser326)磷酸化細(xì)胞核分離基因C蛋白抗體
xy-11573R    Neuro D神經(jīng)特異性轉(zhuǎn)錄因子DPF1抗體
xy-11591R    NAT8 + NAT8BN-乙酰轉(zhuǎn)移酶8抗體
xy-11592R    NAT8BN-乙酰轉(zhuǎn)移酶8B抗體
xy-11595R    NOMO1NOMO蛋白抗體
xy-6945R    NKCC1鈉鉀離子轉(zhuǎn)運(yùn)蛋白1抗體
xy-8601R    hydrogen exchanger 3鈉離子/氫離子交換蛋白3抗體
xy-9582R    phospho-NHE3(Ser552)磷酸化鈉離子/氫離子交換蛋白3抗體
xy-11017R    NPTX2神經(jīng)細(xì)胞穿透素2抗體
xy-11102R    Neprilysin 2腦啡肽酶2抗體
xy-4976R    H1N1 NucleoproteinA型流感病毒核蛋白抗體
xy-11094R    NCAM2神經(jīng)細(xì)胞粘附分子2抗體
xy-6911R    Nidogen巢蛋白1抗體
xy-8150R    NPFF嗎啡痛覺調(diào)節(jié)肽NPFF抗體
xy-6631R    Neurotensin神經(jīng)緊張素抗體
xy-6632R    NESG1鼻咽上皮細(xì)胞特異性蛋白1抗體
xy-5782R    NR2F2載脂蛋白AI調(diào)節(jié)蛋白1抗體
xy-5829R    NG2黑色素瘤硫酸軟骨素蛋白多糖抗體
xy-5755R    Nucleoprotein TPR核蛋白易位啟動(dòng)子區(qū)域TPR抗體
xy-11900R    NFIX核因子1X抗體