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泛素激活酶2B抗體

英文名稱 Ube2B
中文名稱 泛素激活酶2B抗體
別    名 hHR6B; HR6B; RAD6 homolog B; RAD6B; UBE2B; UBE2B_HUMAN; Ubiquitin carrier protein B; Ubiquitin conjugating enzyme E2 B; Ubiquitin protein ligase B; Ubiquitin-conjugating enzyme E2 17 kDa; Ubiquitin-conjugating enzyme E2 B; Ubiquitin-conjugating enzyme E2-17 kDa; Ubiquitin-protein ligase B.
  
說 明 書 0.1ml  0.2ml  
研究領(lǐng)域 腫瘤  免疫學(xué)  信號轉(zhuǎn)導(dǎo)  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, Pig, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 17kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human Ube2B
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In association with the E3 enzyme BRE1 (RNF20 and/or RNF40), it plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B at 'Lys-120' to form H2BK120ub1. H2BK120ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, omeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. In vitro catalyzes 'Lys-11'-, as well as 'Lys-48'- and 'Lys-63'-linked polyubiquitination. Required for postreplication repair of UV-damaged DNA. Associates to the E3 ligase RAD18 to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono-ubiquitination of DNA-associated PCNA on 'Lys-164'. May be involved in neurite outgrowth.

Function:
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In association with the E3 enzyme BRE1 (RNF20 and/or RNF40), it plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B at 'Lys-120' to form H2BK120ub1. H2BK120ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, omeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. In vitro catalyzes 'Lys-11'-, as well as 'Lys-48'- and 'Lys-63'-linked polyubiquitination. Required for postreplication repair of UV-damaged DNA. Associates to the E3 ligase RAD18 to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono-ubiquitination of DNA-associated PCNA on 'Lys-164'. May be involved in neurite outgrowth.

Subunit:
Interacts with RAD18, UBR2 and WAC.xy-5519R    phospho-NRP1(Thr916)磷酸化神經(jīng)纖毛蛋白1抗體
xy-4140R    NF11型神經(jīng)纖維瘤抗體
xy-5520R    phospho-NF1(Ser2515)磷酸化1型神經(jīng)纖維瘤抗體
xy-4141R    NUDEL中心粒蛋白Nudel抗體
xy-5522R    phospho-NDEL1(Ser231)磷酸化中心粒蛋白Nudel抗體
xy-5088R    NSDHL類固醇脫氫酶樣蛋白NSDHL抗體
xy-8441R    Phospho-NFKB1(Ser373)磷酸化細(xì)胞核因子p50/k基因結(jié)合核因子抗體
xy-5521R    phospho-NF1(Ser2817)磷酸化1型神經(jīng)纖維瘤抗體
xy-8448R    Phospho-NMDAR2B (Tyr1474)磷酸化谷氨酸受體2B抗體
xy-5510R    Phospho-NFKB1 (Thr931)磷酸化細(xì)胞核因子p50/k基因結(jié)合核因子抗體
xy-5511R    Phospho-NFKB1 (Ser907)磷酸化細(xì)胞核因子p50/k基因結(jié)合核因子抗體
xy-5512R    Phospho-NFKB1 (Ser337)磷酸化細(xì)胞核因子p50/k基因結(jié)合核因子抗體
xy-5513R    Phospho-NFKB1 (Ser893)磷酸化細(xì)胞核因子p50/k基因結(jié)合核因子抗體
xy-5514R    Phospho-NFKBIA (Tyr42) 磷酸化IKB α抗體
xy-5515R    phospho-NFKBIA(Tyr305)磷酸化IKB alpha抗體
xy-5516R    phospho-NFATc2(Ser330)磷酸化核因子活化T細(xì)胞胞漿蛋白2抗體
xy-10156R    NOX5還原型輔酶Ⅱ氧化酶5/煙酰胺腺嘌呤二核苷酸磷酸抗體
xy-6314R    NANOS2生殖細(xì)胞增殖相關(guān)蛋白NANOS2抗體
xy-3622R    NFKB p52細(xì)胞核因子/k基因結(jié)合核因子 p52/p100抗體
xy-3723R    Phospho-NFKB2(Ser866+Ser870)磷酸化細(xì)胞核因子/k基因結(jié)合核因子p100抗體
xy-2798R    NAT2N-乙?；D(zhuǎn)移酶2抗體
xy-6717R    NALP2富含亮氨酸重復(fù)結(jié)構(gòu)域蛋白2抗體
xy-4636R    NR2C2孤兒核受體TAK1抗體
xy-10227R    Nanos3骨巢蛋白抗體
xy-13710R    Netrin 5軸突生長誘向因子5抗體
xy-2513R    phospho-NFKBIA(Ser32/36)磷酸化p-IκB-α抗體
xy-6079R    G21 proteinG21蛋白質(zhì)抗體
xy-2184R    NQO1醌氧化還原酶抗體
xy-1070R    NPY1R神經(jīng)肽Y1受體抗體
xy-1068R    NMDAR1 谷氨酸受體1抗體
xy-5968R    NARG2谷氨酸受體調(diào)節(jié)蛋白2抗體
xy-6077R    NIT1腈水解酶1抗體
xy-6349R    Nerve growth factor inducible神經(jīng)生長因子誘導(dǎo)蛋白抗體
xy-7665R    NUP50核孔蛋白50抗體