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泛素結(jié)合酶E2變異體1抗體

英文名稱(chēng) UBE2V1
中文名稱(chēng) 泛素結(jié)合酶E2變異體1抗體
別    名 CIR1; CROC-1; CROC1; CROC1A; TRAF6-regulated IKK activator 1 beta Uev1A; UB2V1_HUMAN; UBE2V 1; UBE2V; UBE2V1; Ubiquitin conjugating enzyme E2 variant 1; Ubiquitin-conjugating enzyme E2 variant 1; UEV-1; UEV1.

說(shuō) 明 書(shū) 0.1ml  0.2ml  
研究領(lǐng)域 細(xì)胞生物  染色質(zhì)和核信號(hào)  信號(hào)轉(zhuǎn)導(dǎo)  細(xì)胞周期蛋白  細(xì)胞分化  表觀遺傳學(xué)  
抗體來(lái)源 Rabbit
克隆類(lèi)型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, Chicken, Pig, Horse, Sheep, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 16kDa
細(xì)胞定位 細(xì)胞核 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human UBE2V1
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
Has no ubiquitin ligase activity on its own. The UBE2V1-UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through Lys-63. This type of poly-ubiquitination activates IKK and does not seem to involve protein degradation by the proteasome. Plays a role in the activation of NF-kappa-B mediated by IL1B, TNF, TRAF6 and TRAF2. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage.

Function:
Has no ubiquitin ligase activity on its own. TheUBE2V1-UBE2N heterodimer catalyzes the synthesis of non-canonicalpoly-ubiquitin chains that are linked through Lys-63. This type ofpoly-ubiquitination activates IKK and does not seem to involveprotein degradation by the proteasome. Plays a role in theactivation of NF-kappa-B mediated by IL1B, TNF, TRAF6 and TRAF2.Mediates transcriptional activation of target genes. Plays a rolein the control of progress through the cell cycle anddifferentiation. Plays a role in the error-free DNA repair pathwayand contributes to the survival of cells after DNA damage.

Subunit:
Heterodimer with UBE2N. Interacts (UBE2V2-UBE2Nheterodimer) with the E3 ligase STUB1 (via the U-box domain); thecomplex has a specific 'Lys-63'-linked polyubiquitination activity.Interacts with TRAF6. 

Subcellular Location:
Nucleus. Note=Excluded from the nucleolus.xy-11920R    OTP螺旋轉(zhuǎn)錄因子OTP抗體
xy-2086R    ompF小腸結(jié)腸炎耶爾森氏菌膜通道蛋白抗體
xy-9368R    OCEL1緊密連接蛋白/小分子膠原蛋白OCEL1抗體
xy-12143R    SHANK3富含脯氨酸突觸相關(guān)蛋白SHANK3抗體
xy-12154R    Oncomodulin癌調(diào)蛋白/癌鈣蛋白抗體
xy-1200R    Omgp少突細(xì)胞髓磷脂糖蛋白抗體
xy-1081R    OPCML阿片樣物質(zhì)結(jié)合蛋白/細(xì)胞粘附分子樣蛋白抗體
xy-13615R    ODF4外致密纖維精子尾部蛋白4抗體
xy-15588R    OAS22'-5'-寡腺苷酸合成酶2抗體
xy-3623R    mu Opioid receptorμ-型阿片受體抗體
xy-3712R    Phospho-delta Opioid Receptor (Ser363)磷酸化D型阿片受體抗體
xy-5089R    OXCT1含氧酸輔酶A轉(zhuǎn)移酶1抗體
xy-5095R    Oncostatin M抑瘤素M抗體
xy-5096R    OSMR抑瘤素M受體抗體
xy-12274R    OVOL2鋅指蛋白339抗體
xy-4248R    ORP150氧氣調(diào)節(jié)蛋白150抗體
xy-2927R    OXSR1氧化應(yīng)激反應(yīng)蛋白1抗體
xy-11919R    ODZ1固生蛋白M抗體
xy-8038R    OGFOD1末端多聚腺苷酸1蛋白抗體
xy-11061R    Optimedin嗅球蛋白3抗體
xy-11596R    OTX1轉(zhuǎn)錄因子OTX1抗體
xy-11597R    OTX2轉(zhuǎn)錄因子OTX2抗體
xy-11958R    OTX1 + OTX2轉(zhuǎn)錄因子OTX1+OTX2抗體
xy-11303R    Orexin B增食欲素B/欲激素B
xy-1294R    ODC鳥(niǎo)氨酸脫羧酶抗體
xy-6996R    O-GlcNAc transferaseO位N-乙酰葡萄糖胺OGT抗體
xy-8548R    OLIG1少突膠質(zhì)細(xì)胞轉(zhuǎn)錄因子1
xy-0606R    SLC22A6陰離子轉(zhuǎn)運(yùn)蛋白-1抗體
xy-0609R    OAT-3陰離子轉(zhuǎn)運(yùn)蛋白-3抗體
xy-1314R    Oxytocin R催產(chǎn)素受體(縮宮素受體)抗體
xy-1495R    OCLN緊密連接蛋白抗體
xy-7001R    OCIAD1卵巢癌免疫反應(yīng)抗原抗體
xy-2699R    OMPC大腸桿菌外膜孔道蛋白C抗體
xy-2693R    Plexin B1神經(jīng)叢蛋白B1抗體
xy-5560R    phospho-PRKCZ(Thr410)磷酸化蛋白激酶C(T410)抗體