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端粒調(diào)控因子2抗體

英文名稱 Tankyrase 2
中文名稱 端粒調(diào)控因子2抗體
別    名 ADP-ribosyltransferase diphtheria toxin-like 6; ARTD6; PARP 5b; PARP 5c; PARP-5b; PARP-5c; PARP5B; PARP5C; pART6; Poly [ADP ribose] polymerase 5B; Poly [ADP-ribose] polymerase 5B; TANK2; Tankyrase 2; Tankyrase II; Tankyrase like protein; Tankyrase related protein; Tankyrase TRF1 interacting ankyrin related ADP ribose polymerase 2; Tankyrase-2; Tankyrase-like protein; Tankyrase-related protein; TNKL; TNKS 2; TNKS-2; TNKS2; TNKS2_HUMAN; TRF1 Interacting Ankyrin Related ADP ribose polymerase 2; TRF1-interacting ankyrin-related ADP-ribose polymerase 2.

說 明 書 0.2ml  
研究領(lǐng)域 細(xì)胞生物  信號轉(zhuǎn)導(dǎo)  表觀遺傳學(xué)  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, Dog, Pig, Cow, Horse, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 127kDa
細(xì)胞定位 細(xì)胞漿 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human Tankyrase 2
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the
PubMed PubMed
產(chǎn)品介紹 Function:
Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, omere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of omere length. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles.

Subcellular Location:
Cytoplasm. Golgi apparatus membrane. Nucleus. Chromosome > omere. Associated with the Golgi and with juxtanuclear SLC2A4/GLUT4-vesicles. Also found around the pericentriolar matrix of mitotic centromeres. During interphase, a small fraction of TNKS2 is found in the nucleus, associated with TRF1.

Tissue Specificity:
Highly expressed in placenta, skeletal muscle, liver, brain, kidney, heart, thymus, spinal cord, lung, peripheral blood leukocytes, pancreas, lymph nodes, spleen, prostate, testis, ovary, small intestine, colon, mammary gland, breast and breast carcinoma, and in common-type meningioma. Highly expressed in fetal liver, heart and brain.xy-11356R    ABCA4神經(jīng)元突觸膜胞外分泌調(diào)節(jié)蛋白1抗體
xy-11357R    RIM2神經(jīng)元突觸膜胞外分泌調(diào)節(jié)蛋白2抗體
xy-9252R    RNF130環(huán)指蛋白130抗體
xy-9609R    RBM26RNA結(jié)合蛋白26抗體
xy-9265R    RNF32環(huán)指蛋白32抗體
xy-6872R    RING finger protein 189環(huán)指蛋白189抗體
xy-7613R    RNF144BE3泛素蛋白連接酶144B/環(huán)指蛋白144B抗體
xy-9606R    RBM20RNA結(jié)合蛋白20抗體
xy-9264R    RNF215環(huán)指蛋白215抗體
xy-9283R    RNF187環(huán)指蛋白187抗體
xy-3385R    Phospho-Ret (Tyr1062)磷酸化指狀蛋白RET抗體
xy-0747R    RANKL骨保護(hù)蛋白配體抗體(破骨細(xì)胞分化因子)
xy-1347R    phospho-Rb (Ser780)磷酸化成視網(wǎng)膜細(xì)胞瘤抑癌蛋白抗體
xy-0492R    RGS2G蛋白信號轉(zhuǎn)導(dǎo)調(diào)節(jié)因子2抗體
xy-1379R    Retinoid X receptor核受體RXRα抗體
xy-1166R    ROCK1Rho相關(guān)蛋白激酶1抗體
xy-9229R    RNF156環(huán)指蛋白156抗體
xy-0278R    RRADRRAD抗體
xy-0378R    Runx3Runx3抗體
xy-1221R    Rad51Rad51抗體
xy-0251R    RAR alpha維甲酸受體RAR α/RAR α抗體
xy-0516R    RAR Beta維甲酸受體β抗體
xy-1234R    RASSF1ARas相關(guān)區(qū)域家族1A抗體
xy-0795R    Resistin抵抗素抗體
xy-1180R    RhoARhoA抗體
xy-1205R    ROCK2Rho相關(guān)蛋白激酶2抗體
xy-2467R    STAT4信號轉(zhuǎn)導(dǎo)和轉(zhuǎn)錄激活因子4抗體
xy-2504R    ROS1活性氧簇ROS抗體
xy-5698R    phospho-RAC1(Ser71)磷酸化細(xì)胞遷移誘導(dǎo)因子5抗體
xy-5692R    Phospho-RelB(Ser573)磷酸化核轉(zhuǎn)錄因子NFKB-RelB蛋白抗體
xy-5695R    phospho-RPH3AL(Ser232)磷酸化Ras相關(guān)GTP結(jié)合蛋白抗體
xy-4185R    RelB轉(zhuǎn)錄因子RelB蛋白抗體
xy-4182R    RPA32復(fù)制因子A蛋白2
xy-5693R    phospho-RPA2(Thr21)磷酸化復(fù)制因子A蛋白2抗體
xy-4183R    RPH3ALRas相關(guān)GTP結(jié)合蛋白抗體