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跨膜蛋白43抗體

英文名稱 TMEM43
中文名稱 跨膜蛋白43抗體
別    名 ARVC5; ARVD5; EDMD7; LUMA; Protein LUMA; Tmem43; TMM43_HUMAN; Transmembrane protein 43,

說 明 書 0.2ml  
研究領(lǐng)域 心血管  細(xì)胞生物  染色質(zhì)和核信號  信號轉(zhuǎn)導(dǎo)  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 45kDa
細(xì)胞定位 細(xì)胞核 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human TMEM43
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
This gene belongs to the TMEM43 family. Defects in this gene are the cause of familial arrhythmogenic right ventricular dysplasia type 5 (ARVD5), also known as arrhythmogenic right ventricular cardiomyopathy type 5 (ARVC5). Arrhythmogenic right ventricular dysplasia is an inherited disorder, often involving both ventricles, and is characterized by ventricular tachycardia, heart failure, sudden cardiac death, and fibrofatty replacement of cardiomyocytes. This gene contains a response element for PPAR gamma (an adipogenic transcription factor), which may explain the fibrofatty replacement of the myocardium, a characteristic pathological finding in ARVC. [provided by RefSeq, Oct 2008]

Function:
May have an important role in maintaining nuclear envelope structure by organizing protein complexes at the inner nuclear membrane. Required for retaining emerin at the inner nuclear membrane.

Subcellular Location:
Endoplasmic reticulum. Nucleus inner membrane. Retained in the inner nuclear membrane through interaction with EMD and A-and B-lamins. The N- and C-termini are orientated towards the nucleoplasm. The majority of the hydrophilic domain resides in the endoplasmic reticulum lumen.

Tissue Specificity:
Highest expression in placenta. Also found at lower levels in heart, ovary, spleen, small intestine, thymus, prostate and testis.xy-4538R    TGF Beta 1+2+3轉(zhuǎn)化生長因子β1抗體
xy-4049R    phospho-Tau protein(Ser262)磷酸化微管相關(guān)蛋白抗體
xy-2392R    phospho-Tau protein(Ser404)磷酸化微管相關(guān)蛋白抗體
xy-4042R    Triosephosphate isomerase磷酸丙糖異構(gòu)酶抗體
xy-7702R    TP53TG5p53靶蛋白5抗體
xy-6198R    TROP2細(xì)胞表面糖蛋白Trop2抗體（胰腺癌標(biāo)志物蛋白）
xy-8569R    TFE3轉(zhuǎn)錄因子E3
xy-9689R    C20orf1120號染色體開放閱讀框11抗體
xy-2938R    TdT末端脫氧核苷酸轉(zhuǎn)移酶抗體
xy-6208R    TMED4跨膜蛋白TMED4抗體
xy-6991R    Thrap3甲狀腺激素受體相關(guān)蛋白3抗體
xy-11613R    TAS2R9味覺受體蛋白家族2亞基9抗體
xy-2726R    TPSB2肥大細(xì)胞類胰蛋白酶β2
xy-5525R    phospho-TrkB (Tyr515)磷酸化酪氨酸激酶B抗體
xy-6026R    TSLC1細(xì)胞粘附分子1抗體
xy-3794R    TMEM16A跨膜蛋白16A/鈣激活氯離子通道抗體
xy-2150R    TNF-alpha腫瘤壞死因子-α抗體
xy-7091R    TP53I11腫瘤蛋白P53誘導(dǎo)蛋白11抗體
xy-11789R    TAS2R49味覺2型受體蛋白家族49抗體
xy-9577R    TSPEAR早期未分化視網(wǎng)膜及晶狀體蛋白EURL抗體
xy-11413R    TSKS睪丸特異激酶底物蛋白抗體
xy-4285R    TPX2微管相關(guān)同源蛋白TPX2抗體
xy-7538R    TRIB3神經(jīng)細(xì)胞死亡誘導(dǎo)蛋白激酶抗體
xy-4511R    tubulin Beta微管蛋白β tubulin抗體 Tubulin β
xy-5736R    TACC2轉(zhuǎn)化酸性卷曲含蛋白質(zhì)2
xy-2676M    TSHB小鼠抗促甲狀腺素抗體
xy-6263R    TTBK1腦源性tau蛋白激酶抗體
xy-11772R    Tetanus Toxin heavy chain破傷風(fēng)毒素重鏈抗體
xy-6284R    TKTL1酮基移換酶樣蛋白1抗體
xy-6286R    TMPRSS4膜型絲氨酸蛋白酶2抗體
xy-6113R    TCHP抑癌蛋白TCHP抗體
xy-9428R    Tal1T細(xì)胞急性淋巴細(xì)胞性白血病1蛋白/淋巴瘤蛋白5抗體
xy-9429R    TXNDC9胚胎干細(xì)胞相關(guān)蛋白TXNDC9抗體
xy-9812R    TCF9轉(zhuǎn)錄因子9抗體
xy-1663R    THOC2轉(zhuǎn)錄因子THOC2抗體
xy-9870R    Thymosin beta 4胸腺素β4抗體
xy-4907R    TGF beta 3轉(zhuǎn)移生長因子β3（TGFβ3）抗體