T細(xì)胞淋巴瘤浸潤和轉(zhuǎn)移蛋白2抗體 返回列表頁

T細(xì)胞淋巴瘤浸潤和轉(zhuǎn)移蛋白2抗體

英文名稱 TIAM2
中文名稱 T細(xì)胞淋巴瘤浸潤和轉(zhuǎn)移蛋白2抗體
別    名 FLJ41865; OTTHUMP00000017472; SIF and TIAM1 like exchange factor; SIF and TIAM1-like exchange factor; STEF; T cell lymphoma invasion and metastasis 2; T lymphoma invasion and metastasis inducing protein 2; T-lymphoma invasion and metastasis-inducing protein 2; TIAM 2; TIAM-2; Tiam2; TIAM2_HUMAN.

說 明 書 0.2ml  
研究領(lǐng)域 腫瘤  神經(jīng)生物學(xué)  信號轉(zhuǎn)導(dǎo)  淋巴細(xì)胞  t-淋巴細(xì)胞  G蛋白信號  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 210kDa
細(xì)胞定位 細(xì)胞漿 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human TIAM2
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
This gene encodes a guanine nucleotide exchange factor. A highly similar mouse protein specifically activates ras-related C3 botulinum substrate 1, converting this Rho-like guanosine triphosphatase (GTPase) from a guanosine diphosphate-bound inactive state to a guanosine triphosphate-bound active state. The encoded protein may play a role in neural cell development. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

Function:
Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Mediates extracellular laminin signals to activate Rac1, contributing to neurite growth. Involved in lamellipodial formation and advancement of the growth cone of embryonic hippocampal neurons. Promotes migration of neurons in the cerebral cortex. When overexpressed, induces membrane ruffling accompanied by the accumulation of actin filaments along the altered plasma membrane (By similarity). Activates specifically RAC1, but not CDC42 and RHOA.

Subcellular Location:
Cytoplasm. Cell projection > lamellipodium. Cell projection > filopodium. Cell projection > growth cone. Localizes to the plasma membrane in neurites.xy-7873R    S100 alpha 2S100A2抗體
xy-7901R    SPDYA細(xì)胞周期G2/M期快速誘導(dǎo)蛋白SPDYA抗體
xy-12058R    5HT6 Receptor5-羥色胺受體6抗體
xy-6402R    SMARCA2ATP依賴解旋酶SMARCA2抗體
xy-8389R    SKP1S期激酶相關(guān)蛋白1抗體
xy-8390R    SHFM3SHFM3蛋白抗體
xy-8329R    SRXN1硫氧還蛋白1抗體
xy-7878R    STAM信號轉(zhuǎn)導(dǎo)銜接蛋白1抗體
xy-5332R    phospho-SLK (Tyr530)磷酸化酪氨酸蛋白激酶Fyn/同步原癌基因抗體
xy-9027R    SPTLC2絲氨酸棕櫚酰轉(zhuǎn)移酶2抗體
xy-5616R    Phospho-Smad3 (Ser425)磷酸化細(xì)胞信號轉(zhuǎn)導(dǎo)分子SMAD3抗體
xy-5617R    Phospho-Smad3 (Ser208)磷酸化細(xì)胞信號轉(zhuǎn)導(dǎo)分子SMAD3抗體
xy-5618R    Phospho-Smad2(Thr220)磷酸化細(xì)胞信號轉(zhuǎn)導(dǎo)分子SMAD2抗體
xy-5627R    phospho-Alpha synuclein (Tyr125)磷酸化核突觸蛋白α抗體
xy-5628R    phospho-Alpha synuclein(Ser129)磷酸化核突觸蛋白α抗體
xy-5630R    phospho-SYN1(Ser549)磷酸化神經(jīng)突觸素1抗體
xy-5631R    phospho-SYN1(Ser603) 磷酸化神經(jīng)突觸素1抗體
xy-5632R    phospho-SYN1(Ser62+Ser67)磷酸化神經(jīng)突觸素1抗體
xy-5639R    phospho-STXBP1 (Ser515)磷酸化神經(jīng)突觸前膜胞內(nèi)蛋白抗體
xy-5974R    SMYD3組蛋白甲基轉(zhuǎn)移酶SMYD3抗體
xy-5975R    SSX8滑膜肉瘤X斷點蛋白8抗體
xy-5622R    phospho-STAT6(Thr645)磷酸化信號轉(zhuǎn)導(dǎo)和轉(zhuǎn)錄激活因子6抗體
xy-5623R    Phospho-Stathmin(Ser25)磷酸化原癌基因蛋白18
xy-6257R    STK38絲氨酸/蘇氨酸蛋白激酶38抗體
xy-2945R    SNX1分選連接蛋白1抗體
xy-6159R    STARD8GTP酶激活因子STARD8抗體
xy-6186R    SERPIN A11絲氨酸蛋白酶抑制劑A11抗體
xy-6523R    SCRO鱗狀細(xì)胞癌相關(guān)蛋白抗體
xy-5529R    S100A6S100鈣結(jié)合蛋白A6抗體
xy-4146R    S100A11S100鈣結(jié)合蛋白A11抗體
xy-4165R    S100PS100鈣結(jié)合蛋白P抗體
xy-4145R    SYTL5突觸樣蛋白5亞型2抗體
xy-5942R    SERINC3絲氨酸合并蛋白3抗體（腫瘤差異表達(dá)蛋白）