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跨膜蛋白67抗體

英文名稱 TMEM67/Meckelin
中文名稱 跨膜蛋白67抗體
別    名 JBTS6; Meckel syndrome type 3 protein; MKS3; TMEM67; Transmembrane protein 67.
   
說 明 書 0.2ml  
研究領(lǐng)域 細(xì)胞生物  跨膜蛋白  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 112kDa
細(xì)胞定位 細(xì)胞膜 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human TMEM67/Meckelin
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
The protein encoded by this gene localizes to the primary cilium and to the plasma membrane. The gene functions in centriole migration to the apical membrane and formation of the primary cilium. Multiple transcript variants encoding different isoforms have been found for this gene. Defects in this gene are a cause of Meckel syndrome type 3 (MKS3) and Joubert syndrome type 6 (JBTS6). [provided by RefSeq, Nov 2008]

Function:
Required for ciliary structure and function. Part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition By similarity. Involved in centrosome migration to the apical cell surface during early ciliogenesis. Involved in the regulation of cilia length and appropriate number through the control of centrosome duplication. Required for cell branching morphology. Essential for endoplasmic reticulum-associated degradation (ERAD) of surfactant protein C (SFTPC). 

Subunit:
Part of the tectonic-like complex (also named B9 complex) By similarity. Interacts with DNAJB9, DNAJC10 and mutated SFTPC. Interacts with SYNE2 during the early establishment of cell polarity. Interacts (via C-terminus) with FLNA. 

Subcellular Location:
Cell membrane; Multi-pass membrane protein

Tissue Specificity:
Widely expressed in adult and fetal tissues. Expressed at higher level in spinal cord.xy-0295G-Bio    Goat Anti-rabbit IgG/Bio生物素標(biāo)記的羊抗兔IgG
xy-0294xy-Bio    Donkey Anti-Goat IgG/Bio生物素標(biāo)記的驢抗羊IgG
xy-0296G-Bio    Goat Anti-Mouse IgG/Bio生物素標(biāo)記的羊抗小鼠IgG
xy-0375R-xyE-xyY5    Rabbit Anti-Guinea pig IgM/PE-CY5PE-CY5標(biāo)記的兔抗豚鼠IgM
xy-0293G-xyE    Goat Anti-rat IgG/PEPE標(biāo)記的羊抗大鼠IgG
xy-0293G-xyE-xyy7    Goat Anti-rat IgG/PE-Cy7PE-Cy7標(biāo)記的羊抗大鼠IgG
xy-0358xy-HRxy    Donkey Anti-Guinea pig IgG/HRP辣根過氧化物酶標(biāo)記的驢抗豚鼠IgG
xy-0295G-AF555    Goat Anti-rabbit IgG/Alexa Fluor 555Alexa Fluor 555標(biāo)記的羊抗兔IgG
xy-0295G-AF647    Goat Anti-rabbit IgG/Alexa Fluor 647Alexa Fluor 647標(biāo)記的羊抗兔IgG
xy-0358xy-Bio    Donkey Anti-Guinea pig IgG/Bio生物素標(biāo)記的驢抗豚鼠IgG
xy-0295G-xyy5    Goat Anti-rabbit IgG/Cy5Cy5標(biāo)記的羊抗兔IgG
xy-0295G-xyE-xyy3    Goat Anti-rabbit IgG/PE-Cy3PE-Cy3標(biāo)記的羊抗兔IgG
xy-0295G-Axyxy    Goat Anti-rabbit IgG/APCAPC標(biāo)記的羊抗兔IgG
xy-0295G-xyE    Goat Anti-rabbit IgG/PEPE標(biāo)記的羊抗兔IgG
xy-0295G-xyy3    Goat Anti-rabbit IgG/Cy3Cy3標(biāo)記的羊抗兔IgG
xy-0295G-xyy5.5    Goat Anti-rabbit IgG/Cy5.5Cy5.5標(biāo)記的羊抗兔IgG
xy-0295G-AF350    Goat Anti-rabbit IgG/Alexa Fluor 350Alexa Fluor 350標(biāo)記的羊抗兔IgG
xy-0295G-AF488    Goat Anti-rabbit IgG/Alexa Fluor 488Alexa Fluor 488標(biāo)記的羊抗兔IgG
xy-0296G-AF350    Goat Anti-Mouse IgG/Alexa Fluor 350Alexa Fluor 350標(biāo)記的羊抗小鼠IgG
xy-0296G-AF488    Goat Anti-Mouse IgG/Alexa Fluor 488Alexa Fluor 488標(biāo)記的羊抗小鼠IgG
xy-0296G-AF555    Goat Anti-Mouse IgG/Alexa Fluor 555Alexa Fluor 555標(biāo)記的羊抗小鼠IgG
xy-0296G-AF647    Goat Anti-Mouse IgG/Alexa Fluor 647Alexa Fluor 647標(biāo)記的羊抗小鼠IgG
xy-0296G-xyE-xyY5    Goat Anti-Mouse IgG/PE-CY5PE-CY5標(biāo)記的羊抗小鼠IgG
xy-0296G-xyE-xyy7    Goat Anti-Mouse IgG/PE-Cy7PE-Cy7標(biāo)記的羊抗小鼠IgG
xy-0296G-xyy3    Goat Anti-Mouse IgG/Cy3Cy3標(biāo)記的羊抗小鼠IgG
xy-0296G-xyE    Goat Anti-Mouse IgG/PEPE標(biāo)記的羊抗小鼠IgG
xy-0358M-xyE-xyy7    Mouse Anti-Guinea pig IgG/PE-Cy7PE-Cy7標(biāo)記的小鼠抗豚鼠IgG
xy-0358G-xyy3    Goat Anti-Guinea pig IgG/Cy3Cy3標(biāo)記的羊抗豚鼠IgG
xy-0295G-HRxy    Goat Anti-rabbit IgG/HRP辣根過氧化物酶標(biāo)記的羊抗兔IgG
xy-0294R-xyE    Rabbit Anti-Goat IgG/PEPE標(biāo)記的兔抗羊IgG
xy-0294xy-AF647    Donkey Anti-Goat IgG/Alexa Fluor 647Alexa Fluor 647標(biāo)記的驢抗羊IgG
xy-0294xy-xyE-xyy5.5    Donkey Anti-Goat IgG/PE-Cy5.5PE-Cy5.5標(biāo)記的驢抗羊IgG
xy-0294M-AF350    Mouse Anti-Goat IgG/Alexa Fluor 350Alexa Fluor 350標(biāo)記的小鼠抗羊IgG