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恒定生物鐘同源蛋白TIM1抗體

英文名稱(chēng) Timeless
中文名稱(chēng) 恒定生物鐘同源蛋白TIM1抗體
別    名 FLJ12640; FLJ20714; hTIM; Protein timeless homolog; TIM; TIM_HUMAN; TIM1; Timeless; timeless circadian clock 1; timeless circadian clock; timeless homolog; TIMELESS1; Tof1 homolog.
 
說(shuō) 明 書(shū) 0.2ml  
研究領(lǐng)域 腫瘤  細(xì)胞生物  神經(jīng)生物學(xué)  表觀遺傳學(xué)  
抗體來(lái)源 Rabbit
克隆類(lèi)型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, Dog, Pig, Horse, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 139kDa
細(xì)胞定位 細(xì)胞核 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human Timeless
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
The protein encoded by this gene is highly conserved and is involved in cell survival after damage or stress, increase in DNA polymerase epsilon activity, maintenance of omere length, and epithelial cell morphogenesis. The encoded protein also plays a role in the circadian rhythm autoregulatory loop, interacting with the PERIOD genes (PER1, PER2, and PER3) and others to downregulate activation of PER1 by CLOCK/ARNTL. Changes in this gene or its expression may promote prostate cancer, lung cancer, breast cancer, and mental disorders. [provided by RefSeq, Feb 2014]

Function:
Required for normal progression of S-phase. Involved in the circadian rhythm autoregulatory loop. Negatively regulates CLOCK-NPAS2/BMAL1-induced transactivation of PER1 possibly via translocation of PER1 into the nucleus. Promotes TIPIN nuclear localiZation. Involved in cell survival after DNA damage or replication stress. May be specifically required for the ATR-CHK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light. May also play an important role in epithelial cell morphogenesis and formation of branching tubules.

Subunit:
Homodimer or homomultimer.

Subcellular Location:
Nucleus.xy-0311R-xyy5    Rabbit Anti-Biotin/Cy5Cy5標(biāo)記的兔抗生物素抗體IgG
xy-0311R-xyy5.5    Rabbit Anti-Biotin/Cy5.5Cy5.5標(biāo)記的兔抗生物素抗體IgG
xy-0311R-xyy7    Rabbit Anti-Biotin/Cy7Cy7標(biāo)記的兔抗生物素抗體IgG
xy-0311R-xyE    Rabbit Anti-Biotin/PEPE標(biāo)記的兔抗生物素抗體IgG
xy-0311R-xyE-xyy3    Rabbit Anti-Biotin/PE-Cy3PE-Cy3標(biāo)記的兔抗生物素抗體IgG
xy-0311R-xyE-xyY5    Rabbit Anti-Biotin/PE-CY5PE-CY5標(biāo)記的兔抗生物素抗體IgG
xy-0311R-Axyxy    Rabbit Anti-Biotin/APCAPC標(biāo)記的兔抗生物素抗體IgG
xy-0311R-AF350    Rabbit Anti-Biotin/Alexa Fluor 350Alexa Fluor 350標(biāo)記的兔抗生物素抗體IgG
xy-0311R-AF488    Rabbit Anti-Biotin/Alexa Fluor 488Alexa Fluor 488標(biāo)記的兔抗生物素抗體IgG
xy-0311R-AF555    Rabbit Anti-Biotin/Alexa Fluor 555Alexa Fluor 555標(biāo)記的兔抗生物素抗體IgG
xy-0311R-AF647    Rabbit Anti-Biotin/Alexa Fluor 647Alexa Fluor 647標(biāo)記的兔抗生物素抗體IgG
xy-0311R-xyE-xyy5.5    Rabbit Anti-Biotin/PE-Cy5.5PE-Cy5.5標(biāo)記的兔抗生物素抗體IgG
xy-0311R-xyE-xyy7    Rabbit Anti-Biotin/PE-Cy7PE-Cy7標(biāo)記的兔抗生物素抗體IgG
xy-0311R-Bio    Rabbit Anti-Biotin/Bio生物素標(biāo)記的兔抗生物素抗體IgG
xy-0311R-Axy    Rabbit Anti-Biotin/AP堿性磷酸酶（AP）標(biāo)記的兔抗生物素抗體IgG
xy-0311R-FITxy    Rabbit Anti-Biotin/FITCFITC標(biāo)記的兔抗生物素抗體IgG
xy-0311R-Golxy    Rabbit Anti-Biotin/Gold膠體金標(biāo)記的兔抗生物素抗體IgG
xy-0311R-RBITxy    Rabbit Anti-Biotin/RBITC羅丹明標(biāo)記的兔抗生物素抗體IgG
xy-0326R-RBITxy    Rabbit Anti-Bov IgG/RBITC羅丹明標(biāo)記的兔抗牛IgG
xy-0326R-Axy    Rabbit Anti-Bov IgG/AP堿性磷酸酶（AP）標(biāo)記的兔抗牛IgG
xy-0326R-xyE-xyy7    Rabbit Anti-Bov IgG/PE-Cy7PE-Cy7標(biāo)記的兔抗牛IgG
xy-0326R-Golxy    Rabbit Anti-Bov IgG/Gold膠體金標(biāo)記的兔抗牛IgG
xy-0326R-Bio    Rabbit Anti-Bov IgG/Bio生物素標(biāo)記的兔抗牛IgG
xy-0326R-xyy3    Rabbit Anti-Bov IgG/Cy3Cy3標(biāo)記的兔抗牛IgG
xy-0326R-xyy5    Rabbit Anti-Bov IgG/Cy5Cy5標(biāo)記的兔抗牛IgG
xy-0326R-xyy5.5    Rabbit Anti-Bov IgG/Cy5.5Cy5.5標(biāo)記的兔抗牛IgG
xy-0326R-xyy7    Rabbit Anti-Bov IgG/Cy7Cy7標(biāo)記的兔抗牛IgG
xy-0326R-xyE    Rabbit Anti-Bov IgG/PEPE標(biāo)記的兔抗牛IgG
xy-0326R-xyE-xyy3    Rabbit Anti-Bov IgG/PE-Cy3PE-Cy3標(biāo)記的兔抗牛IgG
xy-0326R-xyE-xyY5    Rabbit Anti-Bov IgG/PE-CY5PE-CY5標(biāo)記的兔抗牛IgG
xy-0326R-Axyxy    Rabbit Anti-Bov IgG/APCAPC標(biāo)記的兔抗牛IgG
xy-0326R-AF350    Rabbit Anti-Bov IgG/Alexa Fluor 350Alexa Fluor 350標(biāo)記的兔抗牛IgG
xy-0326R-AF488    Rabbit Anti-Bov IgG/Alexa Fluor 488Alexa Fluor 488標(biāo)記的兔抗牛IgG
xy-0326R-AF555    Rabbit Anti-Bov IgG/Alexa Fluor 555Alexa Fluor 555標(biāo)記的兔抗牛IgG
xy-0327R-xyE-xyy3    Rabbit Anti-Bovine IgM/PE-Cy3PE-Cy3標(biāo)記的兔抗牛IgM
xy-0327R-xyE-xyY5    Rabbit Anti-Bovine IgM/PE-CY5PE-CY5標(biāo)記的兔抗牛IgM
xy-0327R-Axyxy    Rabbit Anti-Bovine IgM/APCAPC標(biāo)記的兔抗牛IgM
xy-0327R-AF350    Rabbit Anti-Bovine IgM/Alexa Fluor 350Alexa Fluor 350標(biāo)記的兔抗牛IgM
xy-0327R-AF647    Rabbit Anti-Bovine IgM/Alexa Fluor 647Alexa Fluor 647標(biāo)記的兔抗牛IgM
xy-0327R-xyy3    Rabbit Anti-Bovine IgM/Cy3Cy3標(biāo)記的兔抗牛IgM