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DNA拓?fù)洚悩?gòu)酶2結(jié)合蛋白1抗體

英文名稱 TopBP1
中文名稱 DNA拓?fù)洚悩?gòu)酶2結(jié)合蛋白1抗體
別    名 DNA topoisomerase 2 binding protein 1; DNA topoisomerase 2-binding protein 1; DNA topoisomerase II binding protein 1; DNA topoisomerase II binding protein; DNA topoisomerase II-beta-binding protein 1; DNA topoisomerase II-binding protein 1; DNA topoisomerase IIbeta binding protein 1; Hypothetical protein KIAA0259 [Fragment]; KIAA0259; TOP2BP1; *_HUMAN; TOPBP 1; TopBP1; Topoisomerase (DNA) II binding protein 1; Topoisomerase II binding protein 1.

說 明 書 0.1ml  0.2ml  
研究領(lǐng)域 細(xì)胞生物  信號轉(zhuǎn)導(dǎo)  表觀遺傳學(xué)  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, Dog, Cow, Rabbit, Sheep, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 171kDa
細(xì)胞定位 細(xì)胞漿 細(xì)胞膜 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human TopBP1
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
Required for DNA replication. Plays a role in the rescue of stalled replication forks and checkpoint control. Binds double-stranded DNA breaks and nicks as well as single-stranded DNA. Recruits the SWI/SNF chromatin remodeling complex to E2F1-responsive promoters. Down-regulates E2F1 activity and inhibits E2F1-dependent apoptosis during G1/S transition and after DNA damage. Induces a large increase in the kinase activity of ATR.

Subcellular Location:
Nucleus. Cytoplasm; cytoskeleton; centrosome. Cytoplasm; cytoskeleton; spindle pole. Chromosome. Detected on unpaired autosomes in meiotic prophase cells. Detected on X and Y chromosomes during later stages of prophase. Colocalizes with ATR and H2AFX at unsynapsed chromosome cores during prophase (By similarity). Has a uniform nuclear distribution during G phase. Colocalizes with BRCA1 at stalled replication forks during S phase. In mitotic cells it colocalizes with BRCA1 at spindle poles and centrosomes during metaphase and anaphase. Detected in discrete foci together with PML and numerous DNA repair enzymes after DNA damage by alkylating agents, UV or gamma irradiation.

Tissue Specificity:
Highly expressed in heart, brain, placenta, lung and kidney.xy-0439R    ACE血管緊張素轉(zhuǎn)換酶ACE1抗體
xy-1004R    ACE2血管緊張素轉(zhuǎn)換酶2抗體
xy-0120R    AcinusAcinus抗體
xy-1227R    Ack1醋酸激酶1抗體
xy-0443R    ACTH (1-39)促腎上腺皮質(zhì)激素(1-39)抗體
xy-0442R    ACTH (18-39)促腎上腺皮質(zhì)激素ACTH(18-39)抗體
xy-0004R    ACTH (7-23)促腎上腺皮質(zhì)激素ACTH (7-23)抗體
xy-0039R    ADNP活性依賴的神經(jīng)保護(hù)肽抗體
xy-6852R    Alpha 1 Acid Glycoproteinα1酸性糖蛋白1/類粘蛋白1抗體
xy-7565R    Alpha 1 acid glycoprotein 2α1酸性糖蛋白2抗體（類粘蛋白2）
xy-4610R    phospho-AQP2(Ser264+261)磷酸化水通道蛋白2抗體
xy-1907R    ATTY細(xì)胞酪氨酸轉(zhuǎn)氨酶抗體
xy-1930R    Vasopressin抗利尿激素/血管升壓素/加壓素/血管加壓素抗體
xy-1960R    ABCF1ATP結(jié)合盒蛋白家族GCN20F家族1抗體
xy-2405R    AKR1B1醛糖還原酶抗體
xy-0945R    Serum albumin人血清白蛋白抗體
xy-0935R    Anthrax炭疽菌抗體（采用活疫苗制備）
xy-1531R    ATF4活化轉(zhuǎn)錄因子4抗體
xy-0299R    Adenylate Kinase 1腺苷酸激酶-1抗體
xy-1571R    F-Actin纖維狀肌動蛋白抗體
xy-1176R    Agrin聚集蛋白抗體
xy-0037M    AIF調(diào)亡誘導(dǎo)因子抗體
xy-0037R    AIF調(diào)亡誘導(dǎo)因子抗體
xy-0097R    ALK間變型淋巴瘤激酶抗體
xy-0840R    AMACRα-甲基?；o酶A消旋酶抗體
xy-1562R    Annexin A1膜粘連蛋白A1抗體
xy-3602R    ATG1/ULK1自噬相關(guān)蛋白1抗體
xy-2199R    beta Amyloid 1-16β淀粉樣肽1-16/Aβ1-16 抗體
xy-1565R    APCDD1腺瘤肉調(diào)節(jié)蛋白抗體
xy-1632R    APPL1銜接因子蛋白含pH域蛋白1抗體
xy-2506R    AQP7水通道蛋白-7抗體
xy-2532R    ALT1/Alanine Transaminase谷丙氨酸氨基轉(zhuǎn)移酶1抗體
xy-2936R    ARHG7p21活化蛋白激酶ARHG7抗體
xy-6465R    phospho-APE(Ser1417)磷酸化肌動蛋白結(jié)合蛋白Girdin抗體
xy-2640R    ADO2-氨基乙硫醇雙加氧酶抗體