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組織型纖溶酶原激活蛋白抗體

英文名稱 TPA
中文名稱 組織型纖溶酶原激活蛋白抗體
別    名 TPA Tissue Plasminogen Activator; Alteplase; DKFZp686I03148; Plasminogen activator tissue; Plasminogen activator tissue type; PLAT; Reteplase; t PA; T Plasminogen Activator; t-PA; T-plasminogen activator; Tissue plasminogen activator (t PA); Tissue type plasminogen activator; Tissue-type plasminogen activator chain B; tPA; TPA_HUMAN; TPA1.

說 明 書 0.1ml  0.2ml  
研究領(lǐng)域 腫瘤  細胞生物  新陳代謝  泛素  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, Dog, Pig, Cow, Sheep, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 59kDa
細胞定位 分泌型蛋白 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human TPA
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
This gene encodes tissue-type plasminogen activator, a secreted serine protease which converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. Tissue-type plasminogen activator is synthesized as a single chain which is cleaved by plasmin to a two chain disulfide linked protein. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding; decreased activity leads to hypofibrinolysis which can result in thrombosis or embolism. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Function:
Converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physiopathological events. Play a direct role in facilitating neuronal migration.

Subcellular Location:
Secreted > extracellular space.xy-12162R    CYB5R3細胞色素b5還原酶3抗體
xy-11464R    CWC22CWC22蛋白抗體
xy-15349R    C9orf959號染色體開放閱讀框95抗體
xy-13794R    C19orf6719號染色體開放閱讀框67抗體
xy-12426R    phospho-Casein kinase I isoforms gamma 1+2+3 ( Tyr263)磷酸化酪蛋白激酶1γ1+γ2+γ3抗體
xy-8860R    Coproporphyrinogen III Oxidase原卟啉氧化酶3抗體
xy-8987R    Connexin 43間隙連接蛋白43抗體
xy-13745R    CLDN25緊密連接蛋白25抗體
xy-13863R    CEP78中心體蛋白78抗體
xy-15223R    C6orf1466號染色體開放閱讀框146抗體
xy-15226R    C6ORF1546號染色體開放閱讀框154抗體
xy-15316R    C9orf169號染色體開放閱讀框16抗體
xy-15342R    C9orf789號染色體開放閱讀框78抗體
xy-15343R    C9orf79 9號染色體開放閱讀框79抗體
xy-15344R    C9orf849號染色體開放閱讀框84抗體
xy-15345R    C9orf859號染色體開放閱讀框85抗體
xy-15347R    C9ORF919號染色體開放閱讀框91抗體
xy-15348R    C9orf939號染色體開放閱讀框93抗體
xy-15350R    C9orf969號染色體開放閱讀框96抗體
xy-15351R    C9orf989號染色體開放閱讀框98抗體
xy-15497R    CDC5L細胞分裂周期蛋白5樣蛋白抗體
xy-15498R    CDH23 鈣粘蛋白23抗體
xy-15499R    CYP2S1細胞色素p450 2s1抗體
xy-7339R    CK16細胞角蛋白16抗體
xy-10135R    Caspase-6 subunit p11半胱胺酸蛋白酶蛋白-6抗體
xy-10172R    c-fosc-fos抗體
xy-15323R    C9orf239號染色體開放閱讀框23抗體
xy-15324R    C9orf259號染色體開放閱讀框25抗體
xy-15326R    C9orf309號染色體開放閱讀框30抗體
xy-15327R    C9orf379號染色體開放閱讀框37抗體
xy-15328R    C9orf409號染色體開放閱讀框40抗體