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TPIT蛋白抗體

英文名稱 TPIT
中文名稱 TPIT蛋白抗體
別    名 DJ747L4.1; T Box 19; T box factor, pituitary; T box protein 19; T box transcription factor TBX19; T box transcription factor TBX19; TBS 19; TBS19; TBX19; TPIT.
 
說 明 書 0.2ml  
研究領(lǐng)域 細(xì)胞生物  轉(zhuǎn)錄調(diào)節(jié)因子  表觀遺傳學(xué)  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, Chicken, Dog, Cow, Zebrafish, Chimpanzee, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 48kDa
細(xì)胞定位 細(xì)胞核 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human TPIT
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. Mutations in this gene were found in patients with isolated deficiency of pituitary POMC-derived ACTH, suggesting an essential role for this gene in differentiation of the pituitary POMC lineage. ACTH deficiency is characterized by adrenal insufficiency symptoms such as weight loss, lack of appetite (anorexia), weakness, nausea, vomiting, and low blood pressure. [provided by RefSeq, Jul 2008]

Function:
Tpit (TBX19, T box 19) is a highly cell-restricted transcription factor belonging to the T-Box family. T box 19 is required for pro-opeiomelanocortin (POMC) gene expression and differentiation of corticotroph and melanotroph cells. Tpit gene mutations have been shown to be directly correlated to pituitary adrenocorticotropin (ACTH) deficiencies. Tpit functions as a transcriptional activator by recruiting the p160 family of coactivators.

Subcellular Location:
Nuclear xy-9776R    C10orf14010號(hào)染色體開放閱讀框140抗體
xy-9777R    C1orf1251號(hào)染色體開放閱讀框125抗體
xy-9778R    C1orf1291號(hào)染色體開放閱讀框129抗體
xy-9779R    C1orf1591號(hào)染色體開放閱讀框159抗體
xy-9780R    C1orf1631號(hào)染色體開放閱讀框163抗體
xy-9781R    C1orf1721號(hào)染色體開放閱讀框172抗體
xy-9782R    C1orf21號(hào)染色體開放閱讀框2抗體
xy-9783R    C1orf191號(hào)染色體開放閱讀框19抗體
xy-9784R    C1orf251號(hào)染色體開放閱讀框25抗體
xy-9785R    C1orf311號(hào)染色體開放閱讀框31抗體
xy-9786R    C1orf511號(hào)染色體開放閱讀框51抗體
xy-9787R    C1orf521號(hào)染色體開放閱讀框52抗體
xy-9788R    C1orf671號(hào)染色體開放閱讀框67抗體
xy-9789R    C1orf831號(hào)染色體開放閱讀框83抗體
xy-6521R    CRISP3富含半胱氨酸分泌蛋白3抗體
xy-6524R    CT26腫瘤/睪丸抗原26抗體
xy-4270R    CDKN2C細(xì)胞周期蛋白依賴性激酶抑制劑2C抗體
xy-4209R    Cullin 2Cullin2抗體
xy-6225R    CAMK1D鈣調(diào)蛋白激酶CaMK1D抗體
xy-6621R    CHX10CHX10蛋白抗體
xym-2141M    CRIPTO畸胎瘤衍化生長因子單克隆抗體(C端)
xy-4269R    CDKN2B細(xì)胞周期蛋白依賴性激酶抑制劑2B抗體
xym-2313M    CRIPTO畸胎瘤衍化生長因子單克隆抗體
xy-4272R    CHFR泛素連接酶蛋白CHFR抗體
xy-4208R    Cullin 1Cullin1抗體
xy-6598R    Cofilin肌動(dòng)蛋白結(jié)合蛋白CFL抗體
xy-6580R    CDMP1軟骨衍生形態(tài)發(fā)生蛋白1抗體
xy-10032R    Beta-caseinβ-酪蛋白抗體
xy-15121R    c21orf63 21號(hào)染色體開放閱讀框63抗體
xy-15196R    C4orf524號(hào)染色體開放閱讀框52抗體
xy-15193R    C4orf404號(hào)染色體開放閱讀框40抗體
xy-4211R    Cullin 3Cullin3抗體
xy-4295R    CDC40細(xì)胞分裂周期同源蛋白40抗體
xy-5711R    CCDC106卷曲螺旋結(jié)構(gòu)域蛋白106抗體